Citation: Lan Yang, Yu Li, Mou Jiang, Rui Zhou, Hengjiang Cong, Minghui Yang, Lei Zhang, Shenhui Li, Yunhuang Yang, Maili Liu, Xin Zhou, Zhong-Xing Jiang, Shizhen Chen. Fluorinated [2]rotaxanes as sensitive ¹⁹F MRI agents: Threading for higher sensitivity[J]. Chinese Chemical Letters, ;2024, 35(10): 109512. doi: 10.1016/j.cclet.2024.109512 shu

Fluorinated [2]rotaxanes as sensitive ¹⁹F MRI agents: Threading for higher sensitivity

Lan Yang ^{a, c, 1} ,
Yu Li ^{a, 1} ,
Mou Jiang ^{a, b, 1} ,
Rui Zhou ^{a, b} ,
Hengjiang Cong ^c ,
Minghui Yang ^{a, b} ,
Lei Zhang ^{a, b} ,
Shenhui Li ^{a, b} ,
Yunhuang Yang ^{a, b} ,
Maili Liu ^{a, b} ,
Xin Zhou ^{a, b, d} ,
Zhong-Xing Jiang ^{a, b, *,} ,
Shizhen Chen ^{a, b, d, *,}

a.
State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan 430071, China
b.
University of Chinese Academy of Sciences, Beijing 100049, China
c.
School of Pharmaceutical Sciences & College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430071, China
d.
Optics Valley Laboratory, Wuhan 430074, China

zxjiang@apm.ac.cn

chenshizhen@apm.ac.cn

Received Date: 23 September 2023
Revised Date: 22 December 2023
Accepted Date: 8 January 2024
Available Online: 13 January 2024

Figures(3)

As a promising imaging technology, the low sensitivity of fluorine-19 magnetic resonance imaging (¹⁹F MRI) severely hinders its biomedical applications. Herein, we have developed an unprecedented rotaxane-based strategy to improve the sensitivity of ¹⁹F MRI agents. By threading the fluorinated macrocycle into 2-blade pinwheel [2]rotaxanes, the ¹⁹F longitudinal relaxation rate R₁ was dramatically increased, resulting in a significant ¹⁹F MRI signal intensity enhancement of up to 79%. Through comparative molecular dynamics studies using a series of solution and solid-state ¹H/¹⁹F nuclear magnetic resonance (¹H/¹⁹F NMR) and molecular dynamics simulations, it was found that the formation of mechanical bonds dramatically restricts the motion of the wheel fluorines and thus increasing the R₁ for higher ¹⁹F MRI sensitivity. Besides a novel strategy for improving ¹⁹F MRI sensitivity, this study has established ¹⁹F NMR/MRI as a valuable technology for monitoring the molecular dynamics of rotaxanes, which may shed new light on high-performance ¹⁹F MRI agents and molecular devices.
- Rotaxane,
- ¹⁹F MRI,
- Imaging agent,
- Mechanical bond,
- Relaxation rate
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Fluorinated [2]rotaxanes as sensitive 19F MRI agents: Threading for higher sensitivity

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通讯作者: 陈斌, bchen63@163.com

Fluorinated [2]rotaxanes as sensitive ¹⁹F MRI agents: Threading for higher sensitivity