Citation: Keyang Li, Yanan Wang, Yatao Xu, Guohua Shi, Sixian Wei, Xue Zhang, Baomei Zhang, Qiang Jia, Huanhua Xu, Liangmin Yu, Jun Wu, Zhiyu He. Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation[J]. Chinese Chemical Letters, ;2024, 35(10): 109511. doi: 10.1016/j.cclet.2024.109511 shu

Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation

Keyang Li ^{a, b, c, 1} ,
Yanan Wang ^{a, b, 1} ,
Yatao Xu ^{a, b} ,
Guohua Shi ^{a, b} ,
Sixian Wei ^{a, b} ,
Xue Zhang ^{a, b} ,
Baomei Zhang ^{a, b} ,
Qiang Jia ^d ,
Huanhua Xu ^{e, *,} ,
Liangmin Yu ^{a, b} ,
Jun Wu ^{f, *,} ,
Zhiyu He ^{a, b, *,}

a.
Frontiers Science Center for Deep Ocean Multispheres and Earth Systems, Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education/Sanya Oceanographic Institution, Ocean University of China, Qingdao/Sanya 266100/572024, China
b.
College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266003, China
c.
School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
d.
Guangzhou City Polytechnic, Guangzhou 510520, China
e.
National Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China
f.
Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR 999077, China

huanhua323@jxutcm.edu.cn

junwuhkust@ust.hk

hezhiyu@ouc.edu.cn

Received Date: 13 November 2023
Revised Date: 8 January 2024
Accepted Date: 10 January 2024
Available Online: 12 January 2024

Figures(6)

The application of nanotechnologies in formulation has significantly promoted the development of modern medical and pharmacological science, especially for nanoparticle-based drug delivery, bioimaging, and theranostics. The advancement of engineering particle design and fabrication is largely supported by a better understanding of how their apparent characteristics (e.g., size and size distribution, surface morphology, colloidal stability, chemical composition) influence their in vivo biological performance, which raises an urgent need for practical nanoformulation methods. Based on turbulent flow mixing and the self-assembly of molecules in fluids, flash technologies emerged as effective bottom-up fabrication strategies for effective nanoformulation. Among the flash technology family, flash nanocomplexation (FNC) is considered a novel and promising candidate that can promote and optimize formulation processes in a precise spatiotemporal manner, thus obtaining excellent fabrication efficiency, reproducibility and expandability. This review presents an overview of recent advances in fabricating drug-delivery nanoparticles using FNC platforms. Firstly, brief introductions to the basic principles of FNC technology were carried out, followed by descriptions of turbulent microvolume mixers that have significantly promoted the efficiency of FNC-based fabrications. Applications of real formulation cases were then categorized according to the self-assembly-driven interactions (including electrostatic interaction, coordination interaction, hydrogen bonding and hydrophobic interaction) and discussed to reveal the progressiveness of fabricating nanoparticles and discuss how its flexibility will provide advances and replenish the philosophy of nanomedicine formulation. In the end, the commercial potential, current limitations, and prospects of FNC technology for nanoformulation will be summarized and discussed.
- Nanoformulation,
- Nanoparticles,
- Self-assembly,
- Flash nanocomplexation,
- Kinetic control,
- Drug delivery
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