Citation: Xiaoliu Liang, Chunliu Huang, Hui Liu, Hu Chen, Jiabao Shou, Hongwei Cheng, Gang Liu. Natural hydrogel dressings in wound care: Design, advances, and perspectives[J]. Chinese Chemical Letters, ;2024, 35(10): 109442. doi: 10.1016/j.cclet.2023.109442 shu

Natural hydrogel dressings in wound care: Design, advances, and perspectives

Xiaoliu Liang ^{a, 1} ,
Chunliu Huang ^{b, 1} ,
Hui Liu ^{a, 1} ,
Hu Chen ^a ,
Jiabao Shou ^b ,
Hongwei Cheng ^{a, c, *,} ,
Gang Liu ^{a, *,}

a.
State Key Laboratory of Infectious Disease Vaccine Development, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China
b.
Department of Burns and Plastics Surgery, Liuzhou Worker’s Hospital, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545000, China
c.
Institute of Applied Physics and Materials Engineering, Zhuhai UM Science & Technology Research Institute, University of Macau, Macau SAR 999078, China

hongweicheng@um.edu.mo

gangliu.cmitm@xmu.edu.cn

Received Date: 30 September 2023
Revised Date: 13 December 2023
Accepted Date: 19 December 2023
Available Online: 22 December 2023

Figures(2)

Natural hydrogels have emerged as a pivotal innovation in wound care, offering a unique combination of high absorbency, biocompatibility, and versatility. However, due to the complexity of wound healing, the physiological state of the wound varies dynamically, and the mechanism of natural hydrogels that boost wound healing is still unclear. In this review, we firstly provide a comprehensive introduction to the biological process of wound healing, emphasizing the critical stages and factors affecting healing. This work concludes the composition and properties of natural hydrogels, including collagen, gelatin, hyaluronic acid, chitosan, alginates, cellulose, and fibroin, highlighting their biocompatibility and biodegradability. The focus shifts to the various crosslinking strategies employed to enhance the structural integrity and functionality of natural hydrogels. This review further investigates the biological effects of natural hydrogels in wound healing, detailing their antibacterial, antioxidant, anti-inflammatory, adhesive, and hemostatic functions. Furthermore, we propose the challenges and future perspectives of natural hydrogels in practical applications. This review offers a comprehensive overview of the current state and potential future advancements in natural hydrogel dressings for wound care, highlighting their critical role in addressing complex and hard-to-heal wounds.
- Natural hydrogel,
- Wound dressing,
- Crosslinking strategy,
- Antibacterial,
- Anti-inflammation
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沈阳化工大学材料科学与工程学院沈阳 110142