Citation: Jing Zhang, Charles Wang, Yaoyao Zhang, Haining Xia, Yujuan Wang, Kun Ma, Junfeng Wang. Application of magnetotactic bacteria as engineering microrobots: Higher delivery efficiency of antitumor medicine[J]. Chinese Chemical Letters, ;2024, 35(10): 109420. doi: 10.1016/j.cclet.2023.109420 shu

Application of magnetotactic bacteria as engineering microrobots: Higher delivery efficiency of antitumor medicine

Jing Zhang ^{a, b} ,
Charles Wang ^c ,
Yaoyao Zhang ^{a, b} ,
Haining Xia ^{a, b} ,
Yujuan Wang ^{a, d} ,
Kun Ma ^{a, d, *,} ,
Junfeng Wang ^{a, b, d}

a.
High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China
b.
University of Science and Technology of China, Hefei 230026, China
c.
University of California, San Diego, La Jolla, CA 92093, United States
d.
International Magnetobiology Frontier Research Center, Hefei 230031, China

makun@hmfl.ac.cn

Received Date: 26 September 2023
Revised Date: 10 November 2023
Accepted Date: 19 December 2023
Available Online: 22 December 2023

Figures(3)

For a significant duration, enhancing the efficacy of cancer therapy has remained a critical concern. Magnetotactic bacteria (MTB), often likened to micro-robots, hold substantial promise as a drug delivery system. MTB, classified as anaerobic, aquatic, and gram-negative microorganisms, exhibit remarkable motility and precise control over their internal biomineralization processes. This unique ability results in the formation of magnetic nanoparticles arranged along filamentous structures in a catenary fashion, enclosed within a membrane. These bacteria possess distinctive biochemical properties that facilitate their precise positioning within complex environments. By harnessing these biochemical attributes, MTB could potentially offer substantial advantages in the realm of cancer therapy. This article reviews the drug delivery capabilities of MTB in tumor treatment and explores various applications based on their inherent properties. The objective is to provide a comprehensive understanding of MTB-driven drug delivery and stimulate innovative insights in this field.
- Magnetotactic bacteria,
- Engineering microrobot,
- Tumor treatment,
- Drug delivery,
- Bioconjugation
1. [1]
  B.S. Chhikara, K. Parang, Chem. Bio. Lett. 10 (2023) 451.
2. [2]
  J. Zugazagoitia, C. Guedes, S. Ponce, et al., Clinic. Therap. 38 (2016) 1551–1566. doi: 10.1016/j.clinthera.2016.03.026
3. [3]
  C.Y. Jiang, N. Zhang, X.L. Hu, H.Y. Wang, Mol. Cancer 20 (2021) 1–17. doi: 10.1504/ijwmc.2021.10042720
4. [4]
  M. Esposito, S. Ganesan, Y. Kang, Nat. Cancer 2 (2021) 258–270. doi: 10.1038/s43018-021-00181-0
5. [5]
  L.J. Zhang, Z. Li, F.Z. Wang, et al., Adv. Funct. Mater. 32 (2022) 2208404. doi: 10.1002/adfm.202208404
6. [6]
  B.C. Creelan, C. Wang, J.K. Teer, et al., Nat. Med. 27 (2021) 1410–1418. doi: 10.1038/s41591-021-01462-y
7. [7]
  D. Hanahan, R.A. Weinberg, Cell 144 (2011) 646–674. doi: 10.1016/j.cell.2011.02.013
8. [8]
  V.P. Torchilin, Drug Deliv. 197 (2010) 3–53. doi: 10.1007/978-3-642-00477-3_1
9. [9]
  F. Danhier, O. Feron, V. Préat, J. Control. Release 148 (2010) 135–146. doi: 10.1016/j.jconrel.2010.08.027
10. [10]
  S.K. Sriraman, B. Aryasomayajula, V.P. Torchilin, Tissue Barriers 2 (2014) e29528. doi: 10.4161/tisb.29528
11. [11]
  M. Nikolaou, A. Pavlopoulou, A.G. Georgakilas, E. Kyrodimos, Clinic. Exper. Metastasis 35 (2018) 309–318. doi: 10.1007/s10585-018-9903-0
12. [12]
  M. Kartal Yandim, A. Adan Gokbulut, Y. Baran, Critic. Rev. Biotechnol. 36 (2016) 716–726. doi: 10.3109/07388551.2015.1015957
13. [13]
  S.M. Kim, P.H. Faix, J.E. Schnitzer, J. Control. Release 267 (2017) 15–30. doi: 10.1016/j.jconrel.2017.09.016
14. [14]
  C.K. Schmidt, M. Medina Sánchez, R.J. Edmondson, O.G. Schmidt, Nat. Commun. 11 (2020) 5618. doi: 10.1038/s41467-020-19322-7
15. [15]
  D. Rosenblum, N. Joshi, W. Tao, J.M. Karp, D. Peer, Nat. Commun. 9 (2018) 1410. doi: 10.1038/s41467-018-03705-y
16. [16]
  S. Song, M.S. Vuai, M. Zhong, Infectious Agents Cancer 13 (2018) 1–7. doi: 10.4055/cios.2018.10.1.1
17. [17]
  S.J. Park, S.H. Park, S. Cho, et al., Sci. Rep. 3 (2013) 3394. doi: 10.1038/srep03394
18. [18]
  I. Cheong, S.B. Zhou, Method. Enzymol. 465 (2009) 251–265. doi: 10.1016/S0076-6879(09)65013-8
19. [19]
  S.C. Nallar, D.Q. Xu, D.V. Kalvakolanu, Cytokine 89 (2017) 160–172. doi: 10.1016/j.cyto.2016.01.002
20. [20]
  K. Yazawa, M. Fujimori, J. Amano, Y. Kano, S.I. Taniguchi, Cancer Gene Ther. 7 (2000) 269–274. doi: 10.1038/sj.cgt.7700122
21. [21]
  A. Chakrabarty, J. Bacteriol. 185 (2003) 2683–2686. doi: 10.1128/JB.185.9.2683-2686.2003
22. [22]
  Z. Mi, Z.C. Feng, C. Li, et al., J. Cancer 10 (2019) 4765. doi: 10.7150/jca.32650
23. [23]
  F. Badie, M. Ghandali, S.A. Tabatabaei, et al., Front. Oncol. 11 (2021) 624759. doi: 10.3389/fonc.2021.624759
24. [24]
  W.S. Yoon, Y.S. Chae, J. Hong, Y.K. Park, Appl. Microbio. Biotechnol. 89 (2011) 1807–1819. doi: 10.1007/s00253-010-3006-4
25. [25]
  D. Park, S.J. Park, S. Cho, et al., Biotechnol. Bioengin. 111 (2014) 134–143. doi: 10.1002/bit.25007
26. [26]
  S.N. Jiang, T.X. Phan, T.K. Nam, et al., Molecular therapy 18 (2010) 635–642. doi: 10.1038/mt.2009.295
27. [27]
  Y.L. Zhang, W. Ji, L. He, et al., Theranostics 8 (2018) 1690. doi: 10.7150/thno.21575
28. [28]
  S. Chowdhury, S. Castro, C. Coker, et al., Nat. Med. 25 (2019) 1057–1063. doi: 10.1038/s41591-019-0498-z
29. [29]
  W.H. Chang, J.J. Liu, C.H. Chen, T.S. Huang, F.J. Lu, Nutrition Cancer 43 (2002) 214–226. doi: 10.1207/S15327914NC432_12
30. [30]
  T. Ohta, S. Nakatsugi, K. Watanabe, et al., Carcinogenesis 21 (2000) 937–941. doi: 10.1093/carcin/21.5.937
31. [31]
  A. Takagi, M. Kano, C. Kaga, Int. J. Mol. Sci. 16 (2015) 10907–10920. doi: 10.3390/ijms160510907
32. [32]
  N. Schleich, C. Po, D. Jacobs, et al., J. Control. Release 194 (2014) 82–91. doi: 10.1016/j.jconrel.2014.07.059
33. [33]
  J.L. Arias, L.H. Reddy, M. Othman, et al., ACS Nano 5 (2011) 1513–1521. doi: 10.1021/nn1034197
34. [34]
  A.J. Cole, V.C. Yang, A.E. David, Trend. Biotechnol. 29 (2011) 323–332. doi: 10.1016/j.tibtech.2011.03.001
35. [35]
  R. Liu, C. Luo, Z.Q. Pang, et al., Chin. Chem. Lett. 34 (2023) 107518. doi: 10.1016/j.cclet.2022.05.032
36. [36]
  H.P. Hu, L.J. Yu, Z. Ding, et al., Chin. Chem. Lett. 34 (2023) 108592. doi: 10.1016/j.cclet.2023.108592
37. [37]
  D. Kuzajewska, A. Wszołek, W. Żwierełło, L. Kirczuk, A. Maruszewska, Biology (Basel) 9 (2020) 102. doi: 10.3390/biology9050102
38. [38]
  A.S. Mathuriya, Critic. Rev. Biotechnol. 36 (2016) 788–802. doi: 10.3109/07388551.2015.1046810
39. [39]
  S. Rismani Yazdi, R. Nosrati, C.A. Stevens, et al., Small 14 (2018) 1702982. doi: 10.1002/smll.201702982
40. [40]
  S. Martel, Ther Deliv. 8 (2017) 301–312. doi: 10.4155/tde-2016-0088
41. [41]
  C.T. Lefèvre, D.A. Bazylinski, Microbiol. Mol. Bio. Rev. 77 (2013) 497–526. doi: 10.1128/MMBR.00021-13
42. [42]
  W. Lin, D.A. Bazylinski, T. Xiao, L.F. Wu, Y.X. Pan, Environ. Microbio. 16 (2014) 2646–2658. doi: 10.1111/1462-2920.12313
43. [43]
  D. Faivre, D. Schuler, Chem. Rev. 108 (2008) 4875–4898. doi: 10.1021/cr078258w
44. [44]
  D.A. Bazylinski, C.T. Lefèvre, Life 3 (2013) 295–307. doi: 10.3390/life3020295
45. [45]
  P. Goswami, K. He, J.H. Li, et al., Npj Biofilm. Microbio. 8 (2022) 43. doi: 10.1038/s41522-022-00304-0
46. [46]
  S.L. Simmons, D.A. Bazylinski, K.J. Edwards, Science 311 (2006) 371–374. doi: 10.1126/science.1122843
47. [47]
  D.A. Bazylinski, R.B. Frankel, Nat. Rev. Microbio. 2 (2004) 217–230. doi: 10.1038/nrmicro842
48. [48]
  R.B. Frankel, D.A. Bazylinski, Trend. Microbio. 14 (2006) 329–331. doi: 10.1016/j.tim.2006.06.004
49. [49]
  R. Uebe, D. Schüler, Nat. Rev. Microbio. 14 (2016) 621–637. doi: 10.1038/nrmicro.2016.99
50. [50]
  G. Vargas, J. Cypriano, T. Correa, et al., Molecules 23 (2018) 2438. doi: 10.3390/molecules23102438
51. [51]
  J. Wan, C.L. Monteil, A. Taoka, et al., Nat. Commun. 13 (2022) 5652. doi: 10.1038/s41467-022-32914-9
52. [52]
  J.B. Sun, J.H. Duan, S.L. Dai, et al., Biotechnol. Bioengin. 101 (2008) 1313–1320. doi: 10.1002/bit.22011
53. [53]
  C.L. Lyu, G.H. Lu, W. Bao, et al., Chem. Engin. J. 398 (2020) 125453. doi: 10.1016/j.cej.2020.125453
54. [54]
  F. Zhang, L.J. Zhao, S.M. Wang, et al., Adv. Funct. Mater. 28 (2018) 1703326. doi: 10.1002/adfm.201703326
55. [55]
  H.S. Huang, J.F. Hainfeld, Int. J. Nanomed. 8 (2013) 2521–2532.
56. [56]
  M. Sedighi, A. Zahedi Bialvaei, M.R. Hamblin, et al., Cancer Med. 8 (2019) 3167–3181. doi: 10.1002/cam4.2148
57. [57]
  R.K. Jain, N.S. Forbes, Proc. Nat. Acad. Sci. 98 (2001) 14748–14750. doi: 10.1073/pnas.261606598
58. [58]
  M.Q. Wei, K.A. Ellem, P. Dunn, et al., Eur. J. Cancer 43 (2007) 490–496. doi: 10.1016/j.ejca.2006.10.005
59. [59]
  N.S. Forbes, Nat. Rev. Cancer 10 (2010) 785–794. doi: 10.1038/nrc2934
60. [60]
  L.M. Wood, P.D. Guirnalda, M.M. Seavey, Y. Paterson, Immunol. Res. 42 (2008) 233–245. doi: 10.1007/s12026-008-8087-0
61. [61]
  B. Yu, M. Yang, L. Shi, et al., Sci. Rep. 2 (2012) 436. doi: 10.1038/srep00436
62. [62]
  U.E. Martinez Outschoorn, M. Peiris Pagés, R.G. Pestell, F. Sotgia, M.P. Lisanti, Nat. Rev. Clinic. Oncol. 14 (2017) 11–31. doi: 10.1038/nrclinonc.2016.60
63. [63]
  R.M. Ryan, J. Green, P.J. Williams, et al., Gene Ther. 16 (2009) 329–339. doi: 10.1038/gt.2008.188
64. [64]
  C.L. Monteil, K. Benzerara, N. Menguy, et al., ISME J. 15 (2021) 1–18. doi: 10.1038/s41396-020-00747-3
65. [65]
  S. Martel, M. Mohammadi, O. Felfoul, Z. Lu, P. Pouponneau, Int. J. Robotics Res. 28 (2009) 571–582. doi: 10.1177/0278364908100924
66. [66]
  O. Felfoul, M. Mohammadi, S. Taherkhani, et al., Nat. Nanotechnol. 11 (2016) 941–947. doi: 10.1038/nnano.2016.137
67. [67]
  J.H. Xing, T. Yin, S.M. Li, et al., Adv. Funct. Mater. 31 (2021) 2008262. doi: 10.1002/adfm.202008262
68. [68]
  T. Gwisai, N. Mirkhani, M.G. Christiansen, et al., Sci. Robotics 7 (2022) eabo0665. doi: 10.1126/scirobotics.abo0665
69. [69]
  S. Taherkhani, M. Mohammadi, J. Daoud, S. Martel, M. Tabrizian, ACS Nano 8 (2014) 5049–5060. doi: 10.1021/nn5011304
70. [70]
  L. Yan, H.Y. Da, S. Zhang, V.M. López, W.D. Wang, Microbiol. Res. 203 (2017) 19–28. doi: 10.1016/j.micres.2017.06.005
71. [71]
  O. Felfoul, N. Mokrani, M. Mohammadi, S. Martel, in: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology, 2010, pp. 4367–4370.
72. [72]
  N. Lee, H. Kim, S.H. Choi, et al., Proc. Nat. Acad. Sci. U. S. A. 108 (2011) 2662–2667. doi: 10.1073/pnas.1016409108
73. [73]
  B. Wang, Y.W. Qin, J. Liu, et al., ACS Appl. Mater. Interfaces 15 (2023) 2747–2759. doi: 10.1021/acsami.2c19960
74. [74]
  M. Fdez-Gubieda, J. Alonso, A.García Prieto, et al., J. Appl. Phys. 128 (2020) 070902. doi: 10.1063/5.0018036
75. [75]
  P.P. Wang, C.Y. Chen, Q.M. Wang, et al., J. Control. Release 351 (2022) 941–953. doi: 10.1016/j.jconrel.2022.09.059
76. [76]
  S. Martel, 4th Int. Conf. Biomed. Eng. Vietnam 49 (2013) 61–64. doi: 10.1007/978-3-642-32183-2_17
77. [77]
  T.X. Tao, Z.H. Li, S. Xu, et al., Anal. Chem. 95 (2023) 11542–11549. doi: 10.1021/acs.analchem.3c02257
78. [78]
  K. Ma, S. Xu, T.X. Tao, et al., Proc. Nat. Acad. Sci. U. S. A. 119 (2022) e2211228119. doi: 10.1073/pnas.2211228119
79. [79]
  K. Ma, Z. Wang, T.X. Tao, et al., ACS Appl. Nano Mater. 5 (2022) 7410–7417. doi: 10.1021/acsanm.2c01392
80. [80]
  S.H. Ji, Y.D. Chen, X.L. Zhao, et al., Biomater. Sci. 9 (2021) 2732–2742. doi: 10.1039/d0bm01993c
81. [81]
  H. Chen, H.M. Zhang, T.T. Xu, J.F. Yu, ACS Nano 15 (2021) 15625–15644. doi: 10.1021/acsnano.1c07363
82. [82]
  Y. Majedi, D. Loghin, M. Mohammadi, S. Martel, in: Proceedings of the International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS), 2017, pp. 1–6.
83. [83]
  S. Martel, C.C. Tremblay, S. Ngakeng, G. Langlois, Appl. Phys. Lett. 89 (2006) 233904. doi: 10.1063/1.2402221
84. [84]
  Q.F. Ma, C.Y. Chen, S.F. Wei, et al., Biomicrofluidics 6 (2012) 024107. doi: 10.1063/1.3702444
85. [85]
  Q.L. Li, H.T. Chen, X.Y. Feng, et al., Small 15 (2019) 1900427. doi: 10.1002/smll.201900427
86. [86]
  N. Mokrani, O. Felfoul, F.A. Zarreh, et al., in: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology, 2010, pp. 4371–4374.
87. [87]
  F. Afkhami, S. Taherkhani, M. Mohammadi, S. Martel, in: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2011, pp. 6668–6671.
88. [88]
  S.K. Alsaiari, A.H. Ezzedine, A.M. Abdallah, R. Sougrat, N.M. Khashab, OpenNano 1 (2016) 36–45. doi: 10.1016/j.onano.2016.07.001
89. [89]
  G.X. Jiang, Z.C. Xiang, Q.J. Fang, Nanoscale Horiz. 8 (2023) 1062–1072. doi: 10.1039/d3nh00061c
90. [90]
  B.S. Sørensen, M.R. Horsman, Front. Oncol. 10 (2020) 562. doi: 10.3389/fonc.2020.00562
91. [91]
  P. Vaupel, A. Mayer, Cancer Metastasis Rev. 26 (2007) 225–239. doi: 10.1007/s10555-007-9055-1
92. [92]
  O. Trédan, C.M. Galmarini, K. Patel, I.F. Tannock, J. Nat. Cancer Institute 99 (2007) 1441–1454. doi: 10.1093/jnci/djm135
93. [93]
  C.Y. Zhang, L. Yan, Z.J. Gu, Y.L. Zhao, Chem. Sci. 10 (2019) 6932–6943. doi: 10.1039/c9sc02107h
94. [94]
  X.M. Jing, F.M. Yang, C.C. Shao, et al., Mol. Cancer 18 (2019) 1–15. doi: 10.11648/j.iotcc.20190701.11
95. [95]
  I. de Lázaro, D.J. Mooney, Nat. Mater. 19 (2020) 486–487. doi: 10.1038/s41563-020-0669-9
96. [96]
  S. Wilhelm, A.J. Tavares, Q. Dai, et al., Nat. Rev. Mater. 1 (2016) 1–12. doi: 10.1038/natrevmats.2016.14
97. [97]
  K.H. Gupta, C. Nowicki, E.F. Giurini, A.L. Marzo, A. Zloza, Vaccines 9 (2021) 1497. doi: 10.3390/vaccines9121497
98. [98]
  E.F. McCarthy, Iowa Orthopaedic J. 26 (2006) 154.
99. [99]
  R.A. Simon, P.D. Ranasinghe, N. Barazanji, et al., J. Oceanol. Limnol. 39 (2021) 2044–2052. doi: 10.1007/s00343-021-0495-1
100. [100]
  D. Gandia, L. Gandarias, I. Rodrigo, et al., Small 15 (2019) 1902626. doi: 10.1002/smll.201902626
101. [101]
  A. Scheffel, M. Gruska, D. Faivre, et al., Nature 440 (2006) 110–114. doi: 10.1038/nature04382
102. [102]
  D. Murat, A. Quinlan, H. Vali, A. Komeili, Proc. Nat. Acad. Sci. U. S. A. 107 (2010) 5593–5598. doi: 10.1073/pnas.0914439107
103. [103]
  H. Nudelman, R. Zarivach, Front. Microbiol. 5 (2014) 9. doi: 10.3389/fmicb.2014.00009
104. [104]
  A. Dieudonné, D. Pignol, S. Prévéral, Appl. Microbiol. Biotechnol. 103 (2019) 3637–3649. doi: 10.1007/s00253-019-09728-9
105. [105]
  U. Heyen, D. Schüler, Appl. Microbiol. Biotechnol. 61 (2003) 536–544. doi: 10.1007/s00253-002-1219-x
106. [106]
  D. Faivre, N. Menguy, M.l. Pósfai, D. Schüler, Am. Mineralog. 93 (2008) 463–469. doi: 10.2138/am.2008.2678
1. [1]
  Tong Tong , Lezong Chen , Siying Wu , Zhong Cao , Yuanbin Song , Jun Wu . Establishment of a leucine-based poly(ester amide)s library with self-anticancer effect as nano-drug carrier for colorectal cancer treatment. Chinese Chemical Letters, 2024, 35(12): 109689-. doi: 10.1016/j.cclet.2024.109689
2. [2]
  Jiaqi Huang , Renjiang Kong , Yanmei Li , Ni Yan , Yeyang Wu , Ziwen Qiu , Zhenming Lu , Xiaona Rao , Shiying Li , Hong Cheng . Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs. Chinese Chemical Letters, 2024, 35(8): 109254-. doi: 10.1016/j.cclet.2023.109254
3. [3]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
4. [4]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
5. [5]
  Yuanzheng Wang , Chen Zhang , Shuyan Han , Xiaoli Kong , Changyun Quan , Jun Wu , Wei Zhang . Cancer cell membrane camouflaged biomimetic gelatin-based nanogel for tumor inhibition. Chinese Chemical Letters, 2024, 35(11): 109578-. doi: 10.1016/j.cclet.2024.109578
6. [6]
  Makhloufi Zoulikha , Zhongjian Chen , Jun Wu , Wei He . Approved delivery strategies for biopharmaceuticals. Chinese Chemical Letters, 2025, 36(2): 110225-. doi: 10.1016/j.cclet.2024.110225
7. [7]
  Lihang Wang , Mary Li Javier , Chunshan Luo , Tingsheng Lu , Shudan Yao , Bing Qiu , Yun Wang , Yunfeng Lin . Research advances of tetrahedral framework nucleic acid-based systems in biomedicine. Chinese Chemical Letters, 2024, 35(11): 109591-. doi: 10.1016/j.cclet.2024.109591
8. [8]
  Yong-Dan Zhao , Yidan Wang , Rongrong Wang , Lina Chen , Hengtong Zuo , Xi Wang , Jihong Qiang , Geng Wang , Qingxia Li , Canqi Ping , Shuqiu Zhang , Hao Wang . Reversing artemisinin resistance by leveraging thermo-responsive nanoplatform to downregulating GSH. Chinese Chemical Letters, 2024, 35(6): 108929-. doi: 10.1016/j.cclet.2023.108929
9. [9]
  Keyang Li , Yanan Wang , Yatao Xu , Guohua Shi , Sixian Wei , Xue Zhang , Baomei Zhang , Qiang Jia , Huanhua Xu , Liangmin Yu , Jun Wu , Zhiyu He . Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation. Chinese Chemical Letters, 2024, 35(10): 109511-. doi: 10.1016/j.cclet.2024.109511
10. [10]
  Yinglan Yu , Sajid Hussain , Jianping Qi , Lei Luo , Xuemei Zhang . Mechanisms and applications: Cargos transport to basolateral membranes in polarized epithelial cells. Chinese Chemical Letters, 2024, 35(12): 109673-. doi: 10.1016/j.cclet.2024.109673
11. [11]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
12. [12]
  Yi Cao , Xiaojiao Ge , Yuanyuan Wei , Lulu He , Aiguo Wu , Juan Li . Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition. Chinese Chemical Letters, 2024, 35(4): 108672-. doi: 10.1016/j.cclet.2023.108672
13. [13]
  Yunjie Dang , Yanru Feng , Xiao Chen , Chaoxing He , Shujie Wei , Dingyang Liu , Jinlong Qi , Huaxing Zhang , Shaokun Yang , Zhiyun Niu , Bai Xiang . Development of a multi-level pH-responsive lipid nanoplatform for efficient co-delivery of siRNA and small-molecule drugs in tumor treatment. Chinese Chemical Letters, 2024, 35(12): 109660-. doi: 10.1016/j.cclet.2024.109660
14. [14]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
15. [15]
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沈阳化工大学材料科学与工程学院沈阳 110142