Citation: Aolei Tan, Xiaoxiao Ma. Exploring the functional roles of small-molecule metabolites in disease research: Recent advancements in metabolomics[J]. Chinese Chemical Letters, ;2024, 35(8): 109276. doi: 10.1016/j.cclet.2023.109276 shu

Exploring the functional roles of small-molecule metabolites in disease research: Recent advancements in metabolomics

Aolei Tan ,
Xiaoxiao Ma ^*,

Department of Precision Instrument, Tsinghua University, Beijing 100084, China

maxx@tsinghua.edu.cn

Received Date: 19 July 2023
Revised Date: 10 October 2023
Accepted Date: 3 November 2023
Available Online: 5 November 2023

Figures(6)

Metabolism encompasses a series of intricate biochemical processes that are vital for the sustenance of life in organisms. Metabolomics, an essential scientific discipline, is a field of study within the broader domain of systems biology that focuses on the comprehensive analysis of small molecules, known as metabolites including lipids, coenzymes, etc., which are synthesized during metabolism. With the continuous development of metabolomics, the multiple biological functions of metabolites are constantly being discovered, encompassing signal transduction and enzyme stimulation, while concurrently exhibiting associations with afflictions like cancer and diabetes. The comprehension of metabolite functionalities and their intricate interplay with disease conditions assumes paramount importance in both disease-focused research endeavors and the development of diagnostic tools. This scholarly exposition undertakes an extensive review of recent advancements in the investigation of functional roles assumed by metabolites, with specific emphasis on metabolites in lipid synthesis, glucose metabolism and exogenous metabolites.
- Metabolites,
- Small molecules,
- Biological functions,
- Physiological processes,
- Diseases
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沈阳化工大学材料科学与工程学院沈阳 110142