Citation: Jiaqi Huang, Renjiang Kong, Yanmei Li, Ni Yan, Yeyang Wu, Ziwen Qiu, Zhenming Lu, Xiaona Rao, Shiying Li, Hong Cheng. Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs[J]. Chinese Chemical Letters, ;2024, 35(8): 109254. doi: 10.1016/j.cclet.2023.109254 shu

Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs

Jiaqi Huang ^a ,
Renjiang Kong ^a ,
Yanmei Li ^a ,
Ni Yan ^a ,
Yeyang Wu ^a ,
Ziwen Qiu ^a ,
Zhenming Lu ^a ,
Xiaona Rao ^b ,
Shiying Li ^{b, *,} ,
Hong Cheng ^{a, *,}

a.
School of Biomedical Engineering & Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, China
b.
School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China

lisy-sci@gzhmu.edu.cn

chengh@smu.edu.cn

Received Date: 8 September 2023
Revised Date: 26 October 2023
Accepted Date: 27 October 2023
Available Online: 28 October 2023

Figures(5)

Oxidative therapies receive a limited antitumor efficiency due to the insufficient reactive oxygen species (ROS) levels at focal sites and the evolvement of antioxidant defense systems. Herein, we develop an albumin-based nanomedicine to co-deliver chlorin e6 (Ce6) and COH-SR4 (CS), which can simultaneously enhance the yield and lethality of intracellular ROS for amplified photodynamic therapy (PDT). In which, CS acts as both an activator of AMP-activated protein kinase (AMPK) and an inhibitor of glutathione S-transferases (GSTs). Benefiting from it, the prepared HSA-Ce6@COH-SR4 (HCCS) enables positive feedback uptake by promoting AMPK phosphorylation, leading to rapid and extensive tumor accumulation of drugs. As a result, HCCS obviously increases the ROS production to elevate intracellular oxidative stress. Furthermore, HCCS can inhibit GSTs to disturb the antioxidant defense system of tumor cells, intensifying the oxidative damage of ROS. Ultimately, the PDT of HCCS is significantly strengthened by improving the ROS yield and lethality, which greatly declines the proliferation of breast cancer in vivo. This study may open a window in the development of drug co-delivery system for enhanced oxidative therapy of tumors.
- Human serum albumin,
- Drug delivery,
- Reactive oxygen species,
- Positive feedback uptake,
- Oxidative damage
1. [1]
  B.C. Zhang, L. Lin, J.Z. Mao, et al., Chin. Chem. Lett. 34 (2023) 108518. doi: 10.1016/j.cclet.2023.108518
2. [2]
  J. Xu, Y. Lai, F.Y. Wang, et al., Chin. Chem. Lett. 34 (2023) 108332. doi: 10.1016/j.cclet.2023.108332
3. [3]
  X.W. Da, X.L. Liu, C. Li, et al., Chin. Chem. Lett. 34 (2023) 108317. doi: 10.1016/j.cclet.2023.108317
4. [4]
  J.Q. Huang, L.P. Zhao, X. Zhou, et al., Small 18 (2022) 2107467. doi: 10.1002/smll.202107467
5. [5]
  L.P. Zhao, R.R. Zheng, H.Q. Chen, et al., Nano Lett. 20 (2020) 2062–2071. doi: 10.1021/acs.nanolett.0c00047
6. [6]
  X. Zhou, J.Q. Huang, L.S. Liu, et al., ACS Appl. Bio Mater. 4 (2021) 8023–8032. doi: 10.1021/acsabm.1c00938
7. [7]
  Y. Zhou, X. Ren, Z. Hou, et al., Nanoscale Horiz. 6 (2021) 120–131. doi: 10.1039/d0nh00480d
8. [8]
  X. Li, R. Kong, Y. Li, et al., Chem. Commun. 58 (2022) 3917–3920. doi: 10.1039/d2cc00235c
9. [9]
  Z. Chen, L. Liu, R. Liang, et al., ACS Nano 12 (2018) 8633–8645. doi: 10.1021/acsnano.8b04371
10. [10]
  Q. Chen, X. Wang, C. Wang, et al., ACS Nano 9 (2015) 5223–5233. doi: 10.1021/acsnano.5b00640
11. [11]
  Q. Chen, J. Chen, C. Liang, et al., J. Control. Release 263 (2017) 79–89. doi: 10.14321/realanalexch.42.1.0079
12. [12]
  Y. Huang, N. He, Y. Wang, et al., J. Mater. Chem. B 7 (2019) 1149–1159. doi: 10.1039/c8tb03054e
13. [13]
  A. Yuan, J. Wu, C. Song, et al., J. Pharm. Sci. 102 (2013) 1626–1635. doi: 10.1002/jps.23455
14. [14]
  S. Lamichhane, S. Lee, Arch. Pharm. Res. 43 (2020) 118–133. doi: 10.1007/s12272-020-01204-7
15. [15]
  H.X. Lu, L. Noorani, Y.Y. Jiang, et al., J. Mater. Chem. B 5 (2017) 9591–9599. doi: 10.1039/C7TB02902K
16. [16]
  C.R. Park, J.H. Jo, M.G. Song, et al., Theranostics 9 (2019) 7447–7457. doi: 10.7150/thno.34883
17. [17]
  S. Herzig, R. j. Shaw, Nat. Rev. Mol. Cell Biol. 19 (2018) 121–135. doi: 10.1038/nrm.2017.95
18. [18]
  J. Yuan, X. Dong, J. Yap, et al., J. Hematol. Oncol. 13 (2020) 113. doi: 10.1186/s13045-020-00949-4
19. [19]
  R. Li, T.S.C. Ng, S.J. Wang, et al., Nat. Nanotechnol. 16 (2021) 830–839. doi: 10.1038/s41565-021-00897-1
20. [20]
  J.L. Figarola, S. Rahbar, Int. J. Mol. Med. 31 (2013) 1166–1176. doi: 10.3892/ijmm.2013.1313
21. [21]
  Y.Q. Zhu, Y.H. Song, Z.Y. Cao, et al., Adv. Funct. Mater. 31 (2021) 2103655. doi: 10.1002/adfm.202103655
22. [22]
  Z.Y. Cao, D.D. Li, L. Zhao, et al., Nat. Commun. 13 (2022) 2038. doi: 10.1038/s41467-022-29693-8
23. [23]
  S.S. Singhal, J. Figarola, J. Singhal, et al., Biochem. Pharmacol. 84 (2012) 1419–1427. doi: 10.1016/j.bcp.2012.08.020
24. [24]
  A. Chatterjee, S. Gupta, Cancer Lett. 433 (2018) 33–42. doi: 10.1117/12.2290306
25. [25]
  E. Laborde, Cell Death Differ. 17 (2010) 1373–1380. doi: 10.1038/cdd.2010.80
26. [26]
  R.R. Singh, J. Mohammad, O. Megan, et al., Cancers 12 (2020) 1501. doi: 10.3390/cancers12061501
27. [27]
  I.R. Jowsey, A.M. Thomson, J.U. Flanagan, et al., Biochem. J. 359 (2001) 507–516. doi: 10.1042/bj3590507
1. [1]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
2. [2]
  Jing Zhang , Charles Wang , Yaoyao Zhang , Haining Xia , Yujuan Wang , Kun Ma , Junfeng Wang . Application of magnetotactic bacteria as engineering microrobots: Higher delivery efficiency of antitumor medicine. Chinese Chemical Letters, 2024, 35(10): 109420-. doi: 10.1016/j.cclet.2023.109420
3. [3]
  Zhaomin Tang , Qian He , Jianren Zhou , Shuang Yan , Li Jiang , Yudong Wang , Chenxing Yao , Huangzhao Wei , Keda Yang , Jiajia Wang . Active-transporting of charge-reversal Cu(Ⅱ)-doped mesoporous silica nanoagents for antitumor chemo/chemodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109742-. doi: 10.1016/j.cclet.2024.109742
4. [4]
  Kun-Heng Li , Hong-Yang Zhao , Dan-Dan Wang , Ming-Hui Qi , Zi-Jian Xu , Jia-Mi Li , Zhi-Li Zhang , Shi-Wen Huang . Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death. Chinese Chemical Letters, 2024, 35(5): 108882-. doi: 10.1016/j.cclet.2023.108882
5. [5]
  Feifei Wang , Hang Yao , Xinyue Wu , Yijian Tang , Yang Bai , Hui Chong , Huan Pang . Metal–organic framework and its composites modulate macrophage polarization in the treatment of inflammatory diseases. Chinese Chemical Letters, 2024, 35(5): 108821-. doi: 10.1016/j.cclet.2023.108821
6. [6]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
7. [7]
  Yong-Dan Zhao , Yidan Wang , Rongrong Wang , Lina Chen , Hengtong Zuo , Xi Wang , Jihong Qiang , Geng Wang , Qingxia Li , Canqi Ping , Shuqiu Zhang , Hao Wang . Reversing artemisinin resistance by leveraging thermo-responsive nanoplatform to downregulating GSH. Chinese Chemical Letters, 2024, 35(6): 108929-. doi: 10.1016/j.cclet.2023.108929
8. [8]
  Haijing Cui , Weihao Zhu , Chuning Yue , Ming Yang , Wenzhi Ren , Aiguo Wu . Recent progress of ultrasound-responsive titanium dioxide sonosensitizers in cancer treatment. Chinese Chemical Letters, 2024, 35(10): 109727-. doi: 10.1016/j.cclet.2024.109727
9. [9]
  Keyang Li , Yanan Wang , Yatao Xu , Guohua Shi , Sixian Wei , Xue Zhang , Baomei Zhang , Qiang Jia , Huanhua Xu , Liangmin Yu , Jun Wu , Zhiyu He . Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation. Chinese Chemical Letters, 2024, 35(10): 109511-. doi: 10.1016/j.cclet.2024.109511
10. [10]
  Yuanyi Zhou , Ke Ma , Jinfeng Liu , Zirun Zheng , Bo Hu , Yu Meng , Zhizhong Li , Mingshan Zhu . Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine? Autophagy regulation also works. Chinese Chemical Letters, 2024, 35(6): 109056-. doi: 10.1016/j.cclet.2023.109056
11. [11]
  Chi Zhang , Ning Ding , Yuwei Pan , Lichun Fu , Ying Zhang . The degradation pathways of contaminants by reactive oxygen species generated in the Fenton/Fenton-like systems. Chinese Chemical Letters, 2024, 35(10): 109579-. doi: 10.1016/j.cclet.2024.109579
12. [12]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
13. [13]
  Min Huang , Ru Cheng , Shuai Wen , Liangtong Li , Jie Gao , Xiaohui Zhao , Chunmei Li , Hongyan Zou , Jian Wang . Ultrasensitive detection of microRNA-21 in human serum based on the confinement effect enhanced chemical etching of gold nanorods. Chinese Chemical Letters, 2024, 35(9): 109379-. doi: 10.1016/j.cclet.2023.109379
14. [14]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
15. [15]
  Yi Cao , Xiaojiao Ge , Yuanyuan Wei , Lulu He , Aiguo Wu , Juan Li . Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition. Chinese Chemical Letters, 2024, 35(4): 108672-. doi: 10.1016/j.cclet.2023.108672
16. [16]
  Qijun Tang , Wenguang Tu , Yong Zhou , Zhigang Zou . High efficiency and selectivity catalyst for photocatalytic oxidative coupling of methane. Chinese Journal of Structural Chemistry, 2023, 42(12): 100170-100170. doi: 10.1016/j.cjsc.2023.100170
17. [17]
  Jindian Duan , Xiaojuan Ding , Pui Ying Choy , Binyan Xu , Luchao Li , Hong Qin , Zheng Fang , Fuk Yee Kwong , Kai Guo . Oxidative spirolactonisation for modular access of γ-spirolactones via a radical tandem annulation pathway. Chinese Chemical Letters, 2024, 35(10): 109565-. doi: 10.1016/j.cclet.2024.109565
18. [18]
  Yaping Zhang , Wei Zhou , Mingchun Gao , Tianqi Liu , Bingxin Liu , Chang-Hua Ding , Bin Xu . Oxidative cyclization of allyl compounds and isocyanide: A facile entry to polysubstituted 2-cyanopyrroles. Chinese Chemical Letters, 2024, 35(4): 108836-. doi: 10.1016/j.cclet.2023.108836
19. [19]
  Zhe Li , Ping-Zhao Liang , Li Xu , Fei-Yu Yang , Tian-Bing Ren , Lin Yuan , Xia Yin , Xiao-Bing Zhang . Three positive charge nonapoptotic-induced photosensitizer with excellent water solubility for tumor therapy. Chinese Chemical Letters, 2024, 35(8): 109190-. doi: 10.1016/j.cclet.2023.109190
20. [20]
  Qin Yu , Haisheng He , Jianping Qi , Yi Lu , Wei Wu . Oral delivery of insulin by barbed microneedles actuated by intestinal peristalsis. Chinese Chemical Letters, 2024, 35(9): 109888-. doi: 10.1016/j.cclet.2024.109888

Get Citation

PDF

XML

Metrics

PDF Downloads(2)
Abstract views(255)
HTML views(4)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142