Citation: Ningyue Xu, Jun Wang, Lei Liu, Changyang Gong. Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances[J]. Chinese Chemical Letters, ;2024, 35(8): 109225. doi: 10.1016/j.cclet.2023.109225 shu

Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances

Ningyue Xu ^a ,
Jun Wang ^a ,
Lei Liu ^{a, *,} ,
Changyang Gong ^{b, *,}

a.
Division of Head & Neck Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
b.
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

liuleihx@gmail.com

gongchangyang@scu.edu.cn

chygong14@163.com

Received Date: 11 August 2023
Revised Date: 15 October 2023
Accepted Date: 18 October 2023
Available Online: 20 October 2023

Figures(1)

Radiotherapy (RT) is a crucial treatment for cancer; however, its effectiveness is limited by adverse effects on normal tissues, radioresistance, and tumor recurrence. To overcome these challenges, hydrogels have been employed for delivery of radiosensitizers and other therapeutic agents. This review summarizes recent advancements in the application of hydrogel-based local drug delivery systems for improving the therapeutic efficacy of RT in cancer treatment. Firstly, we introduce the classification and properties of hydrogels. Next, we detail hydrogel-based platforms designed to enhance both external beam radiation therapy and brachytherapy. We also discuss hydrogels used in combination therapy involving RT and immunotherapy. Lastly, we highlight the challenges that hydrogels face in RT. By surveying the latest developments in hydrogel applications for RT, this review aims to provide insights into the development of more effective and targeted cancer therapies.
- Radiotherapy,
- Drug delivery systems,
- Hydrogel,
- Radiation sensitization,
- Combination therapy
1. [1]
  J. Kocarnik, Lancet 395 (2020) 757–758. doi: 10.1016/S0140-6736(19)32046-X
2. [2]
  R.M. Feng, Y.N. Zong, S.M. Cao, R.H. Xu, Cancer Commun. 39 (2019) 22.
3. [3]
  M. Cao, H. Li, D. Sun, W. Chen, Cancer Commun. 40 (2020) 205–210. doi: 10.1002/cac2.12025
4. [4]
  H. Sung, J. Ferlay, R.L. Siegel, et al., CA Cancer J. Clin. 71 (2021) 209–249. doi: 10.3322/caac.21660
5. [5]
  W. Sun, Q. Shi, H. Zhang, et al., Discov. Med. 27 (2019) 45–55.
6. [6]
  M. Chang, Z. Hou, M. Wang, C. Li, J. Lin, Adv. Mater. 33 (2021) 2004788. doi: 10.1002/adma.202004788
7. [7]
  J. Cao, Z. Chen, J. Chi, Y. Sun, Y. Sun, Artif. Cells Nanomed. Biotechnol. 46 (2018) S817–S830.
8. [8]
  R.X. Huang, P.K. Zhou, Signal Transduct. Target. Ther. 5 (2020) 60. doi: 10.1038/s41392-020-0150-x
9. [9]
  G.C. Barnett, C.M.L. West, A.M. Dunning, et al., Nat. Rev. Cancer 9 (2009) 134–142. doi: 10.1038/nrc2587
10. [10]
  W.L. Santivasi, F. Xia, Antioxid. Redox Signal. 21 (2014) 251–259. doi: 10.1089/ars.2013.5668
11. [11]
  Y. Lievens, M. Gospodarowicz, S. Grover, et al., Radiother. Oncol. 125 (2017) 175–177. doi: 10.1016/j.radonc.2017.10.027
12. [12]
  P. Shan, J. Liao, J. Li, et al., Chin. Chem. Lett. 35 (2024) 108545. doi: 10.1016/j.cclet.2023.108545
13. [13]
  C. Chargari, C. Clemenson, I. Martins, J.L. Perfettini, E. Deutsch, Drug Resist. Updates 16 (2013) 10–21. doi: 10.1016/j.drup.2013.01.001
14. [14]
  V.E. Krisnawan, J.A. Stanley, J.K. Schwarz, D.G. DeNardo, Cancers 12 (2020) 2916. doi: 10.3390/cancers12102916
15. [15]
  L. Gong, Y. Zhang, C. Liu, M. Zhang, S. Han, Int. J. Nanomed. 16 (2021) 1083–1102. doi: 10.2147/IJN.S290438
16. [16]
  J. Lin, M. Yin, X. Liu, F. Meng, L. Luo, Macromol. Rapid Commun. 43 (2022) e2200194. doi: 10.1002/marc.202200194
17. [17]
  K.B. Pointer, S.P. Pitroda, R.R. Weichselbaum, Trends Cancer 8 (2022) 9–20. doi: 10.1016/j.trecan.2021.10.003
18. [18]
  Y. Ding, Z. Tong, L. Jin, et al., Adv. Mater. 34 (2022) e2106388. doi: 10.1002/adma.202106388
19. [19]
  G.E. Adams, Br. Med. Bull. 29 (1973) 48–53. doi: 10.1093/oxfordjournals.bmb.a070956
20. [20]
  G. Kursunluoglu, H.A. Kayali, D. Taskiran, Cell Biochem. Biophys. 69 (2014) 707–716. doi: 10.1007/s12013-014-9857-z
21. [21]
  R. Langer, Nature 392 (1998) 5–10.
22. [22]
  V. Schirrmacher, Int. J. Oncol. 54 (2019) 407–419.
23. [23]
  S. Lehnert, Int. J. Radiat. Biol. 98 (2022) 461–465. doi: 10.1080/09553002.2021.2003465
24. [24]
  X. Bai, Z. Bao, S. Bi, et al., Macromol. Biosci. 18 (2018) 1700305. doi: 10.1002/mabi.201700305
25. [25]
  Y. Zhong, J. Zhang, R. Cheng, et al., J. Control. Release 205 (2015) 144–154. doi: 10.1016/j.jconrel.2015.01.012
26. [26]
  K. Luo, H. Wu, Y. Chen, et al., Colloids Surf. B: Biointerfaces 200 (2021) 111591. doi: 10.1016/j.colsurfb.2021.111591
27. [27]
  B. Tan, L. Huang, Y. Wu, J. Liao, J. Biomed. Mater. Res. A 109 (2021) 404–425. doi: 10.1002/jbm.a.37062
28. [28]
  H. Cao, L. Duan, Y. Zhang, J. Cao, K. Zhang, Signal Transduct. Target. Ther. 6 (2021) 426. doi: 10.1038/s41392-021-00830-x
29. [29]
  Y. Liu, M. Zhu, M. Meng, et al., Chin. Chem. Lett. 34 (2023) 107583. doi: 10.1016/j.cclet.2022.06.006
30. [30]
  M.C. Catoira, L. Fusaro, D. Di Francesco, M. Ramella, F. Boccafoschi, J. Mater. Sci. Mater. Med. 30 (2019) 115. doi: 10.1007/s10856-019-6318-7
31. [31]
  A. Sun, X. He, X. Ji, et al., Chin. Chem. Lett. 32 (2021) 2117–2126. doi: 10.1016/j.cclet.2021.01.048
32. [32]
  M. Norouzi, B. Nazari, D.W. Miller, Drug Discov. Today 21 (2016) 1835–1849. doi: 10.1016/j.drudis.2016.07.006
33. [33]
  J. Pushpamalar, P. Meganathan, H.L. Tan, et al., Gels 7 (2021) 153. doi: 10.3390/gels7040153
34. [34]
  Q. Xiao, X. Li, Y. Li, et al., Acta Pharm. Sin. B 11 (2021) 941–960. doi: 10.1016/j.apsb.2020.12.018
35. [35]
  S. Yu, C. He, X. Chen, Macromol. Biosci. 18 (2018) 1800240. doi: 10.1002/mabi.201800240
36. [36]
  Y. Li, J. Rodrigues, H. Tomás, Chem. Soc. Rev. 41 (2012) 2193–2221. doi: 10.1039/C1CS15203C
37. [37]
  Z. Sun, C. Song, C. Wang, Y. Hu, J. Wu, Mol. Pharm. 17 (2020) 373–391.
38. [38]
  Y. Guo, J. Bae, Z. Fang, P. Li, F. Zhao, G. Yu, Chem. Rev. 120 (2020) 7642–7707. doi: 10.1021/acs.chemrev.0c00345
39. [39]
  T. Thambi, Y. Li, D.S. Lee, J. Control. Release 267 (2017) 57–66. doi: 10.1016/j.jconrel.2017.08.006
40. [40]
  L. Zheng, C. Li, X. Huang, et al., Biomaterials 216 (2019) 119220. doi: 10.1016/j.biomaterials.2019.05.031
41. [41]
  F.Y. Huang, L.K. Huang, W.Y. Lin, et al., Appl. Radiat. Isot. 67 (2009) 1405–1411. doi: 10.1016/j.apradiso.2009.02.081
42. [42]
  D.F. Williams, Biomaterials 29 (2008) 2941–2953. doi: 10.1016/j.biomaterials.2008.04.023
43. [43]
  P.M. Kharkar, K.L. Kiick, A.M. Kloxin, Chem. Soc. Rev. 42 (2013) 7335–7372. doi: 10.1039/C3CS60040H
44. [44]
  M. Thanou, J.C. Verhoef, H.E. Junginger, Adv. Drug Deliv. Rev. 52 (2001) 117–126. doi: 10.1016/S0169-409X(01)00231-9
45. [45]
  C.C. Lin, A.T. Metters, Adv. Drug Deliv. Rev. 58 (2006) 1379–1408. doi: 10.1016/j.addr.2006.09.004
46. [46]
  A.C. Marques, P.J. Costa, S. Velho, M.H. Amaral, Drug Discov. Today 26 (2021) 2397–2405. doi: 10.1016/j.drudis.2021.04.012
47. [47]
  S.R. Batool, M.A. Nazeer, D. Ekinci, A. Sahin, S. Kizilel, Int. J. Biol. Macromol. 150 (2020) 315–325. doi: 10.1016/j.ijbiomac.2020.02.042
48. [48]
  R. Jalababu, S.S. Veni, K.V.N.S. Reddy, J. Drug Deliv. Sci. Technol. 44 (2018) 190–204. doi: 10.1016/j.jddst.2017.12.013
49. [49]
  N.A. Peppas, Y. Huang, M. Torres-Lugo, J.H. Ward, J. Zhang, Annu. Rev. Biomed. Eng. 2 (2000) 9–29. doi: 10.1146/annurev.bioeng.2.1.9
50. [50]
  S.W. Kim, Y.H. Bae, T. Okano, Pharm. Res. 9 (1992) 283–290. doi: 10.1023/A:1015887213431
51. [51]
  M. Chen, Z. Wang, W. Suo, Z. Bao, H. Quan, Front. Bioeng. Biotechnol. 9 (2021) 757428. doi: 10.3389/fbioe.2021.757428
52. [52]
  K. Bruggeman, M. Zhang, N. Malagutti, et al., ACS Appl. Mater. Interfaces 14 (2022) 12068–12076. doi: 10.1021/acsami.1c24528
53. [53]
  M. Hamidi, A. Azadi, P. Rafiei, Adv. Drug Deliv. Rev. 60 (2008) 1638–1649. doi: 10.1016/j.addr.2008.08.002
54. [54]
  K. Varaprasad, G.M. Raghavendra, T. Jayaramudu, M.M. Yallapu, R. Sadiku, Mater. Sci. Eng. C Mater. Biol. Appl. 79 (2017) 958–971. doi: 10.1016/j.msec.2017.05.096
55. [55]
  F. Ullah, M.B. Othman, F. Javed, Z. Ahmad, H. . M. Akil, Mater. Sci. Eng. C: Mater. Biol. Appl. 57 (2015) 414–433. doi: 10.1016/j.msec.2015.07.053
56. [56]
  Q. Li, C. Liu, J. Wen, et al., Chin. Chem. Lett. 28 (2017) 1857–1874. doi: 10.1016/j.cclet.2017.05.007
57. [57]
  I. Gibas, H.J.C. Janik, Chem. Chem. Technol. 4 (2010) 297–304. doi: 10.23939/chcht04.04.297
58. [58]
  C. Zhang, J. Niu, J. Li, et al., Chin. Chem. Lett. 35 (2024) 108556. doi: 10.1016/j.cclet.2023.108556
59. [59]
  T. Iizawa, T. Ninomiya, T. Gotoh, S. Sakohara, Polym. J. 36 (2004) 356–360. doi: 10.1295/polymj.36.356
60. [60]
  J.T. Zhang, R. Bhat, K.D. Jandt, Acta Biomater. 5 (2009) 488–497. doi: 10.1016/j.actbio.2008.06.012
61. [61]
  L.H. Sperling, J. Polym. Sci. Macromol. Rev. 12 (1977) 141–180. doi: 10.1002/pol.1977.230120103
62. [62]
  L. Lu, S. Yuan, J. Wang, et al., Curr. Stem. Cell Res. Ther. 13 (2018) 490–496. doi: 10.2174/1574888X12666170612102706
63. [63]
  K. Gul, R.Y. Gan, C.X. Sun, et al., Crit. Rev. Food Sci. Nutr. 62 (2022) 3817–3832. doi: 10.1080/10408398.2020.1870034
64. [64]
  J.Y. Je, S.K. Kim, Adv. Food Nutr. Res. 65 (2012) 121–135.
65. [65]
  J. Kumirska, M. Czerwicka, Z. Kaczyński, et al., Mar. Drugs 8 (2010) 1567–1636. doi: 10.3390/md8051567
66. [66]
  J. Cho, M.C. Heuzey, A. Bégin, P.J. Carreau, Biomacromolecules 6 (2005) 3267–3275. doi: 10.1021/bm050313s
67. [67]
  Y. Yao, M. Xia, H. Wang, et al., Eur. J. Pharm. Sci. 91 (2016) 144–153. doi: 10.1016/j.ejps.2016.06.014
68. [68]
  H. Peng, Q. Huang, H. Yue, et al., Int. J. Pharm. 556 (2019) 97–105. doi: 10.1016/j.ijpharm.2018.11.068
69. [69]
  P. Huang, Y. Zhang, W. Wang, et al., J. Control. Release 220 (2015) 456–464. doi: 10.1016/j.jconrel.2015.11.007
70. [70]
  C.L. Peng, Y.H. Shih, K.S. Liang, et al., Mol. Pharm. 10 (2013) 1854–1864. doi: 10.1021/mp3006424
71. [71]
  S. Gao, W. Zhang, R. Wang, et al., ACS Nano 14 (2020) 1468–1481. doi: 10.1021/acsnano.9b05976
72. [72]
  M.K. Nguyen, D.S. Lee, Macromol. Biosci. 10 (2010) 563–579. doi: 10.1002/mabi.200900402
73. [73]
  X. Chen, J. Chen, B. Li, et al., J. Colloid Interface Sci. 490 (2017) 542–552. doi: 10.1016/j.jcis.2016.11.089
74. [74]
  Y. Wang, Y. Wei, Y. Wu, et al., Int. J. Nanomed. 18 (2023) 743–763. doi: 10.2147/IJN.S394377
75. [75]
  L. Li, J.M. Scheiger, P.A. Levkin, Adv. Mater. 31 (2019) e1807333. doi: 10.1002/adma.201807333
76. [76]
  Z. Meng, Y. Chao, X. Zhou, et al., ACS Nano 12 (2018) 9412–9422. doi: 10.1021/acsnano.8b04544
77. [77]
  Z. Wang, W. Zeng, Z. Chen, et al., Colloids Surf. B: Biointerfaces 207 (2021) 112026. doi: 10.1016/j.colsurfb.2021.112026
78. [78]
  J.G. Leprince, W.M. Palin, M.A. Hadis, J. Devaux, G. Leloup, Dent. Mater. 29 (2013) 139–156. doi: 10.1016/j.dental.2012.11.005
79. [79]
  T. Fourniols, L.D. Randolph, A. Staub, et al., J. Control. Release 210 (2015) 95–104. doi: 10.1016/j.jconrel.2015.05.272
80. [80]
  Y.A. Mørch, I. Donati, B.L. Strand, G. Skjåk-Braek, Biomacromolecules 7 (2006) 1471–1480. doi: 10.1021/bm060010d
81. [81]
  Y. Chao, L. Xu, C. Liang, et al., Nat. Biomed. Eng. 2 (2018) 611–621. doi: 10.1038/s41551-018-0262-6
82. [82]
  A.G. Solano, J. Dupuy, H. Therriault, et al., Carbohydr. Polym. 266 (2021) 118115. doi: 10.1016/j.carbpol.2021.118115
83. [83]
  M. Zhao, C. Ji, H. Dai, et al., ACS Appl. Mater. Interfaces 15 (2023) 4984–4995. doi: 10.1021/acsami.2c20467
84. [84]
  L. Sun, F. Shen, L. Tian, et al., Adv. Mater. 33 (2021) e2007910. doi: 10.1002/adma.202007910
85. [85]
  N.G. Burnet, R. Wurm, J. Nyman, J.H. Peacock, Clin. Oncol. 8 (1996) 25–34. doi: 10.1016/S0936-6555(05)80035-4
86. [86]
  H.E. Barker, J.T. Paget, A.A. Khan, K.J. Harrington, Nat. Rev. Cancer 15 (2015) 409–425. doi: 10.1038/nrc3958
87. [87]
  K. Graham, E. Unger, Int. J. Nanomed. 13 (2018) 6049–6058. doi: 10.2147/IJN.S140462
88. [88]
  S. GuhaSarkar, K. Pathak, N. Sudhalkar, et al., Int. J. Nanomed. 11 (2016) 6435–6448. doi: 10.2147/IJN.S110525
89. [89]
  J.F. Fowler, G.E. Adams, J. Denekamp, Cancer Treat. Rev. 3 (1976) 227–256. doi: 10.1016/S0305-7372(76)80012-6
90. [90]
  H. Wang, X. Mu, H. He, X.D. Zhang, Trends Pharmacol. Sci. 39 (2018) 24–48. doi: 10.1016/j.tips.2017.11.003
91. [91]
  J.A. Bertout, S.A. Patel, M.C. Simon, Nat. Rev. Cancer 8 (2008) 967–975. doi: 10.1038/nrc2540
92. [92]
  D. Hanahan, R.A. Weinberg, Cell 144 (2011) 646–674. doi: 10.1016/j.cell.2011.02.013
93. [93]
  A. Rakotomalala, A. Escande, A. Furlan, S. Meignan, E. Lartigau, Front. Endocrinol. 12 (2021) 742215. doi: 10.3389/fendo.2021.742215
94. [94]
  M. Yu, M. Dai, Q. Liu, R. Xiu, Cancer Treat. Rev. 33 (2007) 757–761. doi: 10.1016/j.ctrv.2007.08.002
95. [95]
  S.I. Gundersen, A.F. Palmer, Biotechnol. Prog. 24 (2008) 1353–1364. doi: 10.1002/btpr.56
96. [96]
  W.T. Lee, J. Yoon, S.S. Kim, et al., Pharmaceutics 14 (2022) 148. doi: 10.3390/pharmaceutics14010148
97. [97]
  X. Yang, Y. Wang, T. Mao, et al., Biomater. Sci. 9 (2021) 7471–7482. doi: 10.1039/D1BM01280K
98. [98]
  S. Tokuhiro, Y. Ogawa, K. Tsuzuki, et al., Oncol. Lett. 1 (2010) 1025–1028. doi: 10.3892/ol.2010.184
99. [99]
  S. Morita-Tokuhiro, Y. Ogawa, N. Yokota, et al., Cancers 8 (2016) 10. doi: 10.3390/cancers8010010
100. [100]
  Y. Ogawa, H. Ue, K. Tsuzuki, et al., Oncol. Rep. 19 (2008) 1389–1394.
101. [101]
  S.J. Lunt, B.A. Telfer, R.J. Fitzmaurice, I.J. Stratford, K.J. Williams, Clin. Cancer Res. 11 (2005) 4212–4216. doi: 10.1158/1078-0432.CCR-04-2162
102. [102]
  W.A. Denny, W.R. Wilson, Expert Opin. Investig. Drugs 9 (2000) 2889–2901. doi: 10.1517/13543784.9.12.2889
103. [103]
  K.B. Peters, J.M. Brown, Cancer Res. 62 (2002) 5248–5253.
104. [104]
  S. Ning, N. Yu, D.M. Brown, S. Kanekal, S.J. Knox, Radiother. Oncol. 50 (1999) 215–223. doi: 10.1016/S0167-8140(98)00134-0
105. [105]
  C.G. Milross, K.A. Mason, N.R. Hunter, et al., Eur. J. Cancer 33 (1997) 1299–1308. doi: 10.1016/S0959-8049(97)00107-X
106. [106]
  L. Milas, N.R. Hunter, K.A. Mason, et al., Cancer Res. 55 (1995) 3564–3568.
107. [107]
  L. Milas, N.R. Hunter, K.A. Mason, B. Kurdoglu, L.J. Peters, Cancer Res. 54 (1994) 3506–3510.
108. [108]
  C.J. McGinn, T.S. Lawrence, Semin. Radiat. Oncol. 11 (2001) 270–280. doi: 10.1053/srao.2001.26002
109. [109]
  A.C. Begg, Int. J. Radiat. Oncol. Biol. Phys. 19 (1990) 1183–1189. doi: 10.1016/0360-3016(90)90226-A
110. [110]
  C.T. Coughlin, R.C. Richmond, Semin. Oncol. 16 (1989) 31–43.
111. [111]
  J. Tang, N. Wang, J. Wu, et al., Investig. New Drugs 37 (2019) 1146–1157. doi: 10.1007/s10637-019-00740-4
112. [112]
  S. Xu, Y.Y. Tang, Y.X. Yu, et al., Drug Deliv. 24 (2017) 1139–1147. doi: 10.1080/10717544.2017.1362676
113. [113]
  C. Xie, X. Wan, H. Quan, et al., Cancer Sci. 109 (2018) 1207–1219. doi: 10.1111/cas.13536
114. [114]
  G. Shen, F. Zheng, D. Ren, et al., J. Hematol. Oncol. 11 (2018) 120. doi: 10.1186/s13045-018-0664-7
115. [115]
  Q. Gao, Y. Jiang, X. Li, et al., Front. Oncol. 11 (2021) 628895. doi: 10.3389/fonc.2021.628895
116. [116]
  Z. Fu, H. Li, P. Xue, et al., Front. Bioeng. Biotechnol. 10 (2022) 881544. doi: 10.3389/fbioe.2022.881544
117. [117]
  C. Poluzzi, R.V. Iozzo, L. Schaefer, Adv. Drug Deliv. Rev. 97 (2016) 156–173. doi: 10.1016/j.addr.2015.10.012
118. [118]
  G. Bix, R. Castello, M. Burrows, et al., J. Natl. Cancer Inst. 98 (2006) 1634–1646. doi: 10.1093/jnci/djj441
119. [119]
  K. Zhang, Y. Wang, X. Yu, et al., BMC Cancer 17 (2017) 899. doi: 10.1186/s12885-017-3903-3
120. [120]
  H.Q. Zhuang, Z.Y. Yuan, Cancer Lett. 282 (2009) 9–13. doi: 10.1016/j.canlet.2008.12.008
121. [121]
  N. Wang, Q. Gao, J. Tang, et al., Drug Deliv. 28 (2021) 183–194. doi: 10.1080/10717544.2020.1869864
122. [122]
  L. Milas, Semin. Radiat. Oncol. 11 (2001) 290–299. doi: 10.1053/srao.2001.26018
123. [123]
  K. Kishi, S. Petersen, C. Petersen, et al., Cancer Res. 60 (2000) 1326–1331.
124. [124]
  C. Petersen, S. Petersen, L. Milas, F.F. Lang, P.J. Tofilon, Clin. Cancer Res. 6 (2000) 2513–2520.
125. [125]
  Q. Wang, X. Hou, J. Gao, et al., Chem. Commun. 56 (2020) 13017–13020. doi: 10.1039/D0CC05184E
126. [126]
  L.M. Chow, S.J. Baker, Cancer Lett. 241 (2006) 184–196. doi: 10.1016/j.canlet.2005.11.042
127. [127]
  C.A. Worby, J.E. Dixon, Annu. Rev. Biochem. 83 (2014) 641–669. doi: 10.1146/annurev-biochem-082411-113907
128. [128]
  W.G. McKenna, R.J. Muschel, A.K. Gupta, S.M. Hahn, E.J. Bernhard, Oncogene 22 (2003) 5866–5875. doi: 10.1038/sj.onc.1206699
129. [129]
  M. Tanaka, H.B. Grossman, Gene Ther. 10 (2003) 1636–1642. doi: 10.1038/sj.gt.3302056
130. [130]
  C.J. Rosser, M. Tanaka, L.L. Pisters, et al., Cancer Gene Ther. 11 (2004) 273–279. doi: 10.1038/sj.cgt.7700673
131. [131]
  A. Tomioka, M. Tanaka, M.A. De Velasco, et al., Mol. Cancer Ther. 7 (2008) 1864–1870. doi: 10.1158/1535-7163.MCT-07-2198
132. [132]
  M.K. Leung, J.C. Chow, B.D. Chithrani, et al., Med. Phys. 38 (2011) 624–631. doi: 10.1118/1.3539623
133. [133]
  J.F. Hainfeld, F.A. Dilmanian, D.N. Slatkin, H.M. Smilowitz, J. Pharm. Pharmacol. 60 (2008) 977–985.
134. [134]
  Y. Chen, J. Yang, S. Fu, J. Wu, Int. J. Nanomed. 15 (2020) 9407–9430. doi: 10.2147/IJN.S272902
135. [135]
  S. Her, D.A. Jaffray, C. Allen, Adv. Drug Deliv. Rev. 109 (2017) 84–101. doi: 10.1016/j.addr.2015.12.012
136. [136]
  W. Gao, Y. Zhang, Q. Zhang, L. Zhang, Ann. Biomed. Eng. 44 (2016) 2049–2061. doi: 10.1007/s10439-016-1583-9
137. [137]
  Y. Dou, Y. Guo, X. Li, et al., ACS Nano 10 (2016) 2536–2548. doi: 10.1021/acsnano.5b07473
138. [138]
  S. Luan, R. Xie, Y. Yang, et al., Small 18 (2022) e2200115. doi: 10.1002/smll.202200115
139. [139]
  J.F. Hainfeld, D.N. Slatkin, H.M. Smilowitz, Phys. Med. Biol. 49 (2004) N309–N315. doi: 10.1088/0031-9155/49/18/N03
140. [140]
  Y. Pan, A. Leifert, D. Ruau, et al., Small 5 (2009) 2067–2076. doi: 10.1002/smll.200900466
141. [141]
  J.E. Riviere, M. Jaberi-Douraki, J. Lillich, et al., Nanotoxicology 12 (2018) 1093–1112. doi: 10.1080/17435390.2018.1476986
142. [142]
  E. Lechtman, N. Chattopadhyay, Z. Cai, et al., Phys. Med. Biol. 56 (2011) 4631–4647. doi: 10.1088/0031-9155/56/15/001
143. [143]
  Y.S. Yang, R.P. Carney, F. Stellacci, D.J. Irvine, ACS Nano 8 (2014) 8992–9002. doi: 10.1021/nn502146r
144. [144]
  L. Cui, S. Her, G.R. Bors, et al., Radiother. Oncol. 124 (2017) 344–356. doi: 10.1016/j.radonc.2017.07.007
145. [145]
  N.S. Aminabad, M. Farshbaf, A. Akbarzadeh, Cell Biochem. Biophys. 77 (2019) 123–137. doi: 10.1007/s12013-018-0863-4
146. [146]
  T. Li, M. Zhang, J. Wang, et al., AAPS J. 18 (2016) 146–155. doi: 10.1208/s12248-015-9828-3
147. [147]
  M. Mirrahimi, M. Khateri, J. Beik, et al., J. Biomed. Mater. Res. B: Appl. Biomater. 107 (2019) 2658–2663. doi: 10.1002/jbm.b.34356
148. [148]
  Y. Liu, B.M. Crawford, T. Vo-Dinh, Immunotherapy 10 (2018) 1175–1188. doi: 10.2217/imt-2018-0029
149. [149]
  Z. Alamzadeh, J. Beik, M. Mirrahimi, A. Shakeri-Zadeh, et al., Eur. J. Pharm. Sci. 145 (2020) 105235. doi: 10.1016/j.ejps.2020.105235
150. [150]
  M. Mirrahimi, J. Beik, M. Mirrahimi, et al., Int. J. Biol. Macromol. 158 (2020) 617–626. doi: 10.1016/j.ijbiomac.2020.04.272
151. [151]
  Q. Chen, J. Zhou, Z. Chen, et al., ACS Appl. Mater. Interfaces 11 (2019) 30551–30565. doi: 10.1021/acsami.9b09323
152. [152]
  Z. Dong, L. Feng, Y. Chao, et al., Nano Lett. 19 (2019) 805–815. doi: 10.1021/acs.nanolett.8b03905
153. [153]
  L. Feng, B. Liu, R. Xie, et al., Adv. Funct. Mater. 31 (2021) 2006216. doi: 10.1002/adfm.202006216
154. [154]
  W. Zeng, C. Liu, S. Wang, Z. Wang, Q. Huang, Front. Oncol. 11 (2021) 768829. doi: 10.3389/fonc.2021.768829
155. [155]
  B. Yu, T. Liu, Y. Du, et al., Colloids Surf. B: Biointerfaces 139 (2016) 180–189. doi: 10.1016/j.colsurfb.2015.11.063
156. [156]
  K. Tanderup, C. Ménard, C. Polgar, et al., Adv. Drug Deliv. Rev. 109 (2017) 15–25. doi: 10.1016/j.addr.2016.09.002
157. [157]
  B. Erickson, M.T. Gillin, J. Surg. Oncol. 66 (1997) 285–295. doi: 10.1002/(SICI)1096-9098(199712)66:4<285::AID-JSO14>3.0.CO;2-#
158. [158]
  X. Deng, H. Wu, F. Gao, et al., Int. J. Clin. Oncol. 22 (2017) 641–650. doi: 10.1007/s10147-017-1155-5
159. [159]
  K. Han, M. Milosevic, A. Fyles, M. Pintilie, A.N. Viswanathan, Int. J. Radiat. Oncol. Biol. Phys. 87 (2013) 111–119. doi: 10.1016/j.ijrobp.2013.05.033
160. [160]
  G. Marwaha, R. Macklis, A.D. Singh, A. Wilkinson, Dev. Ophthalmol. 52 (2013) 29–35.
161. [161]
  J.L. Schaal, X. Li, E. Mastria, et al., J. Control. Release 228 (2016) 58–66. doi: 10.1016/j.jconrel.2016.02.040
162. [162]
  Y.H. Shih, X.Z. Lin, C.H. Yeh, et al., Int. J. Nanomed. 9 (2014) 4191–4201.
163. [163]
  A.K. Azab, B. Orkin, V. Doviner, et al., J. Control. Release 111 (2006) 281–289. doi: 10.1016/j.jconrel.2005.12.014
164. [164]
  A.K. Azab, J. Kleinstern, V. Dovine, et al., J. Control. Release 123 (2007) 116–122. doi: 10.1016/j.jconrel.2007.07.014
165. [165]
  J.L. Zhu, S.W. Yu, P.K. Chow, Y.W. Tong, J. Li, Biomaterials 180 (2018) 163–172. doi: 10.1016/j.biomaterials.2018.07.023
166. [166]
  D.R. Fisher, J. Fidel, C.A. Maitz, Cancer Biother. Radiopharm. 35 (2020) 1–9.
167. [167]
  Y. Kim, D.R. Seol, S. Mohapatra, et al., Int. J. Radiat. Oncol. Biol. Phys. 88 (2014) 1142–1147. doi: 10.1016/j.ijrobp.2013.12.025
168. [168]
  S. Kim, S.G. Yim, A. Chandrasekharan, et al., J. Control. Release 322 (2020) 337–345. doi: 10.1016/j.jconrel.2020.03.046
169. [169]
  K. Liu, D. Zheng, J. Zhao, et al., J. Mater. Chem. B 6 (2018) 4738–4746. doi: 10.1039/C8TB01295D
170. [170]
  P. Puente, N. Fettig, M.J. Luderer, et al., J. Pharm. Sci. 107 (2018) 922–933. doi: 10.1016/j.xphs.2017.10.042
171. [171]
  S. Lee, B. Son, G. Park, et al., Int. J. Mol. Sci. 19 (2018) 2795. doi: 10.3390/ijms19092795
172. [172]
  R. Xing, Y. Liu, Q. Zou, X. Yan, Nanoscale 11 (2019) 22182–22195. doi: 10.1039/C9NR06266A
173. [173]
  X. Li, J.F. Lovell, J. Yoon, X. Chen, Nat. Rev. Clin. Oncol. 17 (2020) 657–674. doi: 10.1038/s41571-020-0410-2
174. [174]
  D.E. Dolmans, D. Fukumura, R.K. Jain, Nat. Rev. Cancer 3 (2003) 380–387. doi: 10.1038/nrc1071
175. [175]
  R. Mukerji, J. Schaal, X. Li, et al., Biomaterials 79 (2016) 79–87. doi: 10.1016/j.biomaterials.2015.11.064
176. [176]
  J. Liu, Y. Zhang, Q. Li, et al., Acta Biomater. 114 (2020) 133–145. doi: 10.1016/j.actbio.2020.07.032
177. [177]
  Y. Zhang, Z. Zhang, Cell Mol. Immunol. 17 (2020) 807–821. doi: 10.1038/s41423-020-0488-6
178. [178]
  S.C. Formenti, S. Demaria, J. Natl. Cancer Inst. 105 (2013) 256–265. doi: 10.1093/jnci/djs629
179. [179]
  M.E. Rodríguez-Ruiz, C. Vanpouille-Box, I. Melero, S.C. Formenti, S. Demaria, Trends Immunol. 39 (2018) 644–655. doi: 10.1016/j.it.2018.06.001
180. [180]
  S. Demaria, E.B. Golden, S.C. Formenti, JAMA Oncol. 1 (2015) 1325–1332. doi: 10.1001/jamaoncol.2015.2756
181. [181]
  X. Lan, J. Liang, C. Wen, et al., Chin. Chem. Lett. 35 (2024) 108616. doi: 10.1016/j.cclet.2023.108616
182. [182]
  X. Zhang, X. Guo, Y. Wu, J. Gao, Gels 7 (2021) 224. doi: 10.3390/gels7040224
183. [183]
  Q. Chen, M. Chen, Z. Liu, Chem. Soc. Rev. 48 (2019) 5506–5526. doi: 10.1039/C9CS00271E
184. [184]
  Q. Liu, D. Zhang, H. Qian, et al., Int. J. Nanomed. 15 (2020) 3669–3680. doi: 10.2147/IJN.S249174
185. [185]
  S. Sun, W. Gu, H. Wu, et al., Adv. Funct. Mater. 32 (2022) 2205038. doi: 10.1002/adfm.202205038
186. [186]
  Y. Zhang, Z. Feng, J. Liu, et al., Bioact. Mater. 16 (2022) 359–371.
187. [187]
  K. Vermaelen, Front. Immunol. 10 (2019) 8. doi: 10.3389/fimmu.2019.00008
188. [188]
  U. Sahin, Ö. Türeci, Science 359 (2018) 1355–1360. doi: 10.1126/science.aar7112
189. [189]
  T. Wang, D. Wang, H. Yu, et al., Nat. Commun. 9 (2018) 1532. doi: 10.1038/s41467-018-03915-4
190. [190]
  Y. Lu, C. Wu, Y. Yang, et al., Biomater. Sci. 10 (2022) 1352–1363. doi: 10.1039/D1BM01596F
191. [191]
  Y. Yin, X. Li, H. Ma, et al., Nano Lett. 21 (2021) 2224–2231. doi: 10.1021/acs.nanolett.0c05039
192. [192]
  G.A. Roth, V. Picece, B.S. Ou, et al., Nat. Rev. Mater. 7 (2022) 174–195.
193. [193]
  S.C. Formenti, S. Demaria, Int. J. Radiat. Oncol. Biol. Phys. 84 (2012) 879–880. doi: 10.1016/j.ijrobp.2012.06.020
194. [194]
  G. Driessens, L. Nuttin, A. Gras, et al., Cancer Immunol. Immunother. 60 (2011) 273–281. doi: 10.1007/s00262-010-0941-y
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