Citation: Yongkang Yue, Zhou Xu, Kaiqing Ma, Fangjun Huo, Xuemei Qin, Kuanshou Zhang, Caixia Yin. HSA shrinkage optimizes the photostability of embedded dyes fundamentally to amplify their efficiency as photothermal materials[J]. Chinese Chemical Letters, ;2024, 35(8): 109223. doi: 10.1016/j.cclet.2023.109223 shu

HSA shrinkage optimizes the photostability of embedded dyes fundamentally to amplify their efficiency as photothermal materials

Yongkang Yue ^a ,
Zhou Xu ^{a, b} ,
Kaiqing Ma ^a ,
Fangjun Huo ^c ,
Xuemei Qin ^b ,
Kuanshou Zhang ^d ,
Caixia Yin ^{a, *,}

a.
Department Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China
b.
Department Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
c.
Research Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, China
d.
State Key Laboratory of Quantum Optics and Quantum Optics Devices, Institute of Opto-Electronics, Shanxi University, Taiyuan 030006, China

yincx@sxu.edu.cn

Received Date: 11 August 2023
Revised Date: 15 October 2023
Accepted Date: 19 October 2023
Available Online: 20 October 2023

Figures(5)

Focused on the performance promotion of organic small molecular dyes based photothermal agents via non-chemical modification, we found that heat-assisted binding of human serum albumin (HSA) to the dye causes shrinkage of the protein and encapsulate the dye to form nanoparticles. This revolutionizes the photostability of small molecule dyes which further improves their photothermal conversion efficiency and tumor ablation performance as photothermal agents significantly. In this work, the obtained photothermal agent named HSA-P2-T could accumulate in tumor and induce 22 ℃ enhancement of the tumor in xenograft models upon ultra-low dose (0.1 W/cm²) laser irradiation, which, as far as we know, is the lowest laser dose used in vivo photothermal therapy. Utilizing HSA-P2-T, we realized tumor ablation upon twice intravenous injections of the nanoparticles and four photothermal treatments.
- Photothermal therapy,
- Cyanine dyes,
- Photostability,
- Albumin,
- Encapsulation
1. [1]
  Y. Liu, P. Bhattarai, Z. Dai, X. Chen, Chem. Soc. Rev. 48 (2019) 2053–2108. doi: 10.1039/C8CS00618K
2. [2]
  Z. Xie, T. Fan, J. An, et al., Chem. Soc. Rev. 49 (2020) 8065–8087. doi: 10.1039/d0cs00215a
3. [3]
  M. Ferrari, Nat. Rev. Cancer 5 (2005) 161–171. doi: 10.1038/nrc1566
4. [4]
  H. Si, D. Wang, X. Du, X. Zhou, Chin. Chem. Lett. 35 (2024) 108595. doi: 10.1016/j.cclet.2023.108595
5. [5]
  L. Wang, A. Mei, N. Li, et al., Chin. Chem. Lett. 35 (2024) 108974. doi: 10.1016/j.cclet.2023.108974
6. [6]
  H.S. Jung, P. Verwilst, A. Sharma, et al., Chem. Soc. Rev. 47 (2018) 2280–2297. doi: 10.1039/c7cs00522a
7. [7]
  J. Liu, J. Shi, W. Nie, et al., Adv. Healthc. Mater. 10 (2021) 2001207. doi: 10.1002/adhm.202001207
8. [8]
  K.X. Teng, W.K. Chen, L.Y. Niu, et al., Angew. Chem. Int. Ed. 60 (2021) 19912–19920. doi: 10.1002/anie.202106748
9. [9]
  G. Feng, G.Q. Zhang, D. Ding, Chem. Soc. Rev. 49 (2020) 8179–8234. doi: 10.1039/d0cs00671h
10. [10]
  C. Xu, K. Pu, Chem. Soc. Rev. 50 (2021) 1111–1137. doi: 10.1039/d0cs00664e
11. [11]
  L.R. Hirsch, R.J. Stafford, J.A. Bankson, et al., Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 13549–13554. doi: 10.1073/pnas.2232479100
12. [12]
  D.P. O’Neal, L.R. Hirsch, N.J. Halas, J.D. Payne, J.L. West, Cancer Lett. 209 (2004) 171–176. doi: 10.1016/j.canlet.2004.02.004
13. [13]
  B. Zhou, Y. Li, G. Niu, et al., ACS Appl. Mater. Interfaces 8 (2016) 29899–29905. doi: 10.1021/acsami.6b07838
14. [14]
  L. Zou, H. Wang, B. He, et al., Theranostics 6 (2016) 762–772. doi: 10.7150/thno.14988
15. [15]
  M. Xing, Y. Han, Y. Zhu, et al., Anal. Chem. 94 (2022) 12836–12844. doi: 10.1021/acs.analchem.2c02798
16. [16]
  G. Yang, P. Li, Y. Han, et al., Mater. Chem. Phys. 295 (2023) 127145. doi: 10.1016/j.matchemphys.2022.127145
17. [17]
  L. Tang, P. Li, Y. Han, et al., J. Photochem. Photobiol. A: Chem. 438 (2023) 114511. doi: 10.1016/j.jphotochem.2022.114511
18. [18]
  H. Xin, Y. Huang, Y. Han, et al., Spectrochim. Acta Part A: Mol. Biomol. Spectrosc. 299 (2023) 122876. doi: 10.1016/j.saa.2023.122876
19. [19]
  J.H.M. Van Der Velde, J. Oelerich, J. Huang, et al., Nat. Commun. 7 (2016) 10144. doi: 10.1038/ncomms10144
20. [20]
  Z. Lei, F. Zhang, Angew. Chem. Int. Ed. 60 (2021) 16294–16308. doi: 10.1002/anie.202007040
21. [21]
  P. Cheng, K. Pu, Nat. Rev. Mater. 6 (2021) 1095–1113. doi: 10.1038/s41578-021-00328-6
22. [22]
  A.N. Butkevich, M.L. Bossi, G. Lukinavičius, S.W. Hell, J. Am. Chem. Soc. 141 (2019) 981–989. doi: 10.1021/jacs.8b11036
23. [23]
  Y. Yue, T. Zhao, Y. Wang, et al., Chem. Sci. 13 (2022) 218–224. doi: 10.1039/d1sc05484h
24. [24]
  Y. Fan, F. Wang, F. Hou, et al., Chin. Chem. Lett. 34 (2023) 107557. doi: 10.1016/j.cclet.2022.05.071
25. [25]
  S. Gao, G. Wei, S. Zhang, et al., Nat. Commun. 10 (2019) 2206. doi: 10.1038/s41467-019-10056-9
26. [26]
  R. Tian, Q. Zeng, S. Zhu, et al., Sci. Adv. 5 (2019) eaaw0672. doi: 10.1126/sciadv.aaw0672
27. [27]
  Y. Yue, T. Zhao, Z. Xu, et al., Adv. Sci. 10 (2023) 2205080. doi: 10.1002/advs.202205080
28. [28]
  Q. Chen, Z. Liu, Adv. Mater. 28 (2016) 10557–10566. doi: 10.1002/adma.201600038
29. [29]
  Z. Liu, X. Chen, Chem. Soc. Rev. 45 (2016) 1432–1456. doi: 10.1039/C5CS00158G
30. [30]
  H. Gu, W. Liu, W. Sun, et al., Chem. Sci. 13 (2022) 9719–9726. doi: 10.1039/d2sc02879d
31. [31]
  J. Zielonka, J. Joseph, A. Sikora, et al., Chem. Rev. 117 (2017) 10043–10120. doi: 10.1021/acs.chemrev.7b00042
32. [32]
  J. Kadkhoda, A. Tarighatnia, N.D. Nader, A. Aghanejad, Life Sci. 307 (2022) 120898. doi: 10.1016/j.lfs.2022.120898
33. [33]
  Z. Luo, T. Lv, K. Zhu, et al., Angew. Chem. Int. Ed. 59 (2020) 3131–3136. doi: 10.1002/anie.201915046
34. [34]
  I. Petitpas, A.A. Bhattacharya, S. Twine, M. East, S. Curry, J. Biol. Chem. 276 (2001) 22804–22809. doi: 10.1074/jbc.M100575200
35. [35]
  G. Rabbani, S.N. Ahn, Int. J. Biol. Macromol. 123 (2019) 979–990. doi: 10.1016/j.ijbiomac.2018.11.053
36. [36]
  F. Yang, C. Bian, L. Zhu, et al., J. Struct. Biol. 157 (2007) 348–355. doi: 10.1016/j.jsb.2006.08.015
37. [37]
  H. Alsamamra, K. Kh, S. Darwish, M. Abuteir, J. Med. Physiol. Biophys. 49 (2018) 1–8.
38. [38]
  K. Qian, H. Chen, C. Qu, et al., Nanomed. Nanotechnol. Biol. Med. 23 (2020) 102087. doi: 10.1016/j.nano.2019.102087
39. [39]
  G. Battogtokh, Y.T. Ko, Nanomed. Nanotechnol. Biol. Med. 13 (2017) 733–743. doi: 10.1016/j.nano.2016.10.014
40. [40]
  S. Li, G. Zhang, Y. Peng, et al., Adv. Healthc. Mater. 12 (2023) 2300327. doi: 10.1002/adhm.202300327
41. [41]
  W. Sun, S. Guo, C. Hu, J. Fan, X. Peng, Chem. Rev. 116 (2016) 7768–7817. doi: 10.1021/acs.chemrev.6b00001
42. [42]
  D. Xi, N. Xu, X. Xia, et al., Adv. Mater. 34 (2022) 2106797. doi: 10.1002/adma.202106797
43. [43]
  W. Bian, Y. Wang, Z. Pan, et al., ACS Appl. Nano Mater. 4 (2021) 11353–11385. doi: 10.1021/acsanm.1c01903
44. [44]
  D. Xi, M. Xiao, J. Cao, et al., Adv. Mater. 32 (2020) 1907855. doi: 10.1002/adma.201907855
45. [45]
  H. Dai, Z. Cheng, T. Zhang, et al., Chin. Chem. Lett. 33 (2022) 2501–2506. doi: 10.1016/j.cclet.2021.11.079
46. [46]
  A.M. Smith, M.C. Mancini, S. Nie, Nat. Nanotechnol. 4 (2009) 710–711. doi: 10.1038/nnano.2009.326
47. [47]
  J. Cao, B. Zhu, K. Zheng, et al., Front. Bioeng. Biotechnol. 7 (2020) 487. doi: 10.3389/fbioe.2019.00487
1. [1]
  Supphachok Chanmungkalakul , Syed Ali Abbas Abedi , Federico J. Hernández , Jianwei Xu , Xiaogang Liu . The dark side of cyclooctatetraene (COT): Photophysics in the singlet states of “self-healing” dyes. Chinese Chemical Letters, 2024, 35(8): 109227-. doi: 10.1016/j.cclet.2023.109227
2. [2]
  Yu Qin , Mingyang Huang , Chenlu Huang , Hannah L. Perry , Linhua Zhang , Dunwan Zhu . O₂-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma. Chinese Chemical Letters, 2024, 35(7): 109171-. doi: 10.1016/j.cclet.2023.109171
3. [3]
  Leichen Wang , Anqing Mei , Na Li , Xiaohong Ruan , Xu Sun , Yu Cai , Jinjun Shao , Xiaochen Dong . Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy. Chinese Chemical Letters, 2024, 35(6): 108974-. doi: 10.1016/j.cclet.2023.108974
4. [4]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
5. [5]
  Xiangqian Cao , Chenkai Yang , Xiaodong Zhu , Mengxin Zhao , Yilin Yan , Zhengnan Huang , Jinming Cai , Jingming Zhuang , Shengzhou Li , Wei Li , Bing Shen . Synergistic enhancement of chemotherapy for bladder cancer by photothermal dual-sensitive nanosystem with gold nanoparticles and PNIPAM. Chinese Chemical Letters, 2024, 35(8): 109199-. doi: 10.1016/j.cclet.2023.109199
6. [6]
  Yiqiao Chen , Ao Liu , Biwen Yang , Zhenzhen Li , Binggang Ye , Zhouyi Guo , Zhiming Liu , Haolin Chen . Photoluminescence and photothermal conversion in boric acid derived carbon dots for targeted microbial theranostics. Chinese Chemical Letters, 2024, 35(9): 109295-. doi: 10.1016/j.cclet.2023.109295
7. [7]
  Songtao Cai , Liuying Wu , Yuan Li , Soham Samanta , Jinying Wang , Bing Liu , Feihu Wu , Kaitao Lai , Yingchao Liu , Junle Qu , Zhigang Yang . Intermolecular hydrogen-bonding as a robust tool toward significantly improving the photothermal conversion efficiency of a NIR-II squaraine dye. Chinese Chemical Letters, 2024, 35(4): 108599-. doi: 10.1016/j.cclet.2023.108599
8. [8]
  Tianze Wang , Junyi Ren , Dongxiang Zhang , Huan Wang , Jianjun Du , Xin-Dong Jiang , Guiling Wang . Development of functional dye with redshifted absorption based on Knoevenagel condensation at 1-site in phenyl[b]-fused BODIPY. Chinese Chemical Letters, 2024, 35(6): 108862-. doi: 10.1016/j.cclet.2023.108862
9. [9]
  Jiaqi Huang , Renjiang Kong , Yanmei Li , Ni Yan , Yeyang Wu , Ziwen Qiu , Zhenming Lu , Xiaona Rao , Shiying Li , Hong Cheng . Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs. Chinese Chemical Letters, 2024, 35(8): 109254-. doi: 10.1016/j.cclet.2023.109254
10. [10]
  Tao LIU , Yuting TIAN , Ke GAO , Xuwei HAN , Ru'nan MIN , Wenjing ZHAO , Xueyi SUN , Caixia YIN . A photothermal agent with high photothermal conversion efficiency and high stability for tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1622-1632. doi: 10.11862/CJIC.20240107
11. [11]
  Yuqing Wang , Zhemin Li , Qingjun Lu , Qizhao Li , Jiaxin Luo , Chengjie Li , Yongshu Xie . Solar cells based on doubly concerted companion dyes with the efficiencies modulated by inserting an ethynyl group at different positions. Chinese Chemical Letters, 2024, 35(5): 109093-. doi: 10.1016/j.cclet.2023.109093
12. [12]
  Zikang Hu , Hengjie Zhang , Zhengqiu Li , Tianbao Zhao , Zhipeng Gu , Qijuan Yuan , Baoshu Chen . Multifunctional photothermal hydrogels: Design principles, various functions, and promising biological applications. Chinese Chemical Letters, 2024, 35(10): 109527-. doi: 10.1016/j.cclet.2024.109527
13. [13]
  Junchuan Sun , Lu Wang . Carbon exchange enabled supra-photothermal methane dry reforming. Chinese Journal of Structural Chemistry, 2024, 43(10): 100330-100330. doi: 10.1016/j.cjsc.2024.100330
14. [14]
  Han Han , Bi-Te Chen , Jia-Rong Ding , Jin-Ming Si , Tian-Jiao Zhou , Yi Wang , Lei Xing , Hu-Lin Jiang . A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy. Chinese Chemical Letters, 2024, 35(10): 109583-. doi: 10.1016/j.cclet.2024.109583
15. [15]
  Mengli Xu , Zhenmin Xu , Zhenfeng Bian . Achieving Ullmann coupling reaction via photothermal synergy with ultrafine Pd nanoclusters supported on mesoporous TiO2. Chinese Journal of Structural Chemistry, 2024, 43(7): 100305-100305. doi: 10.1016/j.cjsc.2024.100305
16. [16]
  Ling Yang , Min Ren , Jie Wang , Liming He , Shanshan Wu , Shuai Yang , Wei Zhao , Hao Cheng , Xiaoming Zhou , Maling Gou . A non-viral gene therapy for melanoma by staphylococcal enterotoxin A. Chinese Chemical Letters, 2024, 35(5): 108822-. doi: 10.1016/j.cclet.2023.108822
17. [17]
  Huijie An , Chen Yang , Zhihui Jiang , Junjie Yuan , Zhongming Qiu , Longhao Chen , Xin Chen , Mutu Huang , Linlang Huang , Hongju Lin , Biao Cheng , Hongjiang Liu , Zhiqiang Yu . Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109134-. doi: 10.1016/j.cclet.2023.109134
18. [18]
  Mengjuan Sun , Muye Zhou , Yifang Xiao , Hailei Tang , Jinhua Chen , Ruitao Zhang , Chunjiayu Li , Qi Ya , Qian Chen , Jiasheng Tu , Qiyue Wang , Chunmeng Sun . Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109110-. doi: 10.1016/j.cclet.2023.109110
19. [19]
  Bohan Chen , Liming Gong , Jing Feng , Mingji Jin , Liqing Chen , Zhonggao Gao , Wei Huang . Research advances of nanoparticles for CAR-T therapy in solid tumors. Chinese Chemical Letters, 2024, 35(9): 109432-. doi: 10.1016/j.cclet.2023.109432
20. [20]
  Ying Zhao , Yin-Hang Chai , Tian Chen , Jie Zheng , Ting-Ting Li , Francisco Aznarez , Li-Long Dang , Lu-Fang Ma . Size-controlled synthesis and near-infrared photothermal response of Cp* Rh-based metalla[2]catenanes and rectangular metallamacrocycles. Chinese Chemical Letters, 2024, 35(6): 109298-. doi: 10.1016/j.cclet.2023.109298

Get Citation

PDF

XML

Metrics

PDF Downloads(2)
Abstract views(298)
HTML views(6)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142