Citation: Xiangqian Cao, Chenkai Yang, Xiaodong Zhu, Mengxin Zhao, Yilin Yan, Zhengnan Huang, Jinming Cai, Jingming Zhuang, Shengzhou Li, Wei Li, Bing Shen. Synergistic enhancement of chemotherapy for bladder cancer by photothermal dual-sensitive nanosystem with gold nanoparticles and PNIPAM[J]. Chinese Chemical Letters, ;2024, 35(8): 109199. doi: 10.1016/j.cclet.2023.109199 shu

Synergistic enhancement of chemotherapy for bladder cancer by photothermal dual-sensitive nanosystem with gold nanoparticles and PNIPAM

Xiangqian Cao ^{a, 1} ,
Chenkai Yang ^{a, 1} ,
Xiaodong Zhu ^{b, 1} ,
Mengxin Zhao ^b ,
Yilin Yan ^a ,
Zhengnan Huang ^a ,
Jinming Cai ^a ,
Jingming Zhuang ^a ,
Shengzhou Li ^a ,
Wei Li ^{b, *,} ,
Bing Shen ^{a, *,}

a.
Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
b.
Department of Nanomedicine & Shanghai Key Lab of Cell Engineering, Naval Medical University, Shanghai 200433, China

liwei_dds@163.com

urodrshenbing@shsmu.edu.cn

Received Date: 2 July 2023
Revised Date: 10 October 2023
Accepted Date: 12 October 2023
Available Online: 13 October 2023

Figures(4)

Bladder cancer is a common malignant tumor of the urinary system with the potential to be treated by nano drug delivery system. The current work describes the synthesis and characterization of a novel nanomaterial to construct a nano-carrier based on 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphatecholine (POPC) loaded doxorubicin (DOX) and embedded with gold nanoparticles and poly(N-isopropyl acrylamide) (PNIPAM) (GNPS@PNIPAM-POPC-DOX, GPPD). The dual-sensitive nanosystem gives simultaneous photothermal treatment and chemotherapy for bladder cancer. In vitro and in vivo properties were assessed using bladder cancer cell lines and mice and GPPD system distribution, tumor inhibition, and biocompatibility are reported. The system had favorable stability, low biological toxicity, controlled release efficiency, photothermal synergistic action, efficient photothermal transition, and favorable tumor suppressive effects. As a result, GPPD is a potential therapeutic approach for bladder cancer.
- Doxorubicin,
- Gold nanoparticles,
- Thermosensitive polymer,
- Photothermal therapy,
- Bladder cancer
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