Citation: Jin Wang, Xiaoyan Pan, Junyu Zhang, Qingqing Zhang, Yanchen Li, Weiwei Guo, Jie Zhang. Active molecule-based theranostic agents for tumor vasculature normalization and antitumor efficacy[J]. Chinese Chemical Letters, ;2024, 35(8): 109187. doi: 10.1016/j.cclet.2023.109187 shu

Active molecule-based theranostic agents for tumor vasculature normalization and antitumor efficacy

Jin Wang ^{a, 1} ,
Xiaoyan Pan ^{a, 1} ,
Junyu Zhang ^a ,
Qingqing Zhang ^a ,
Yanchen Li ^a ,
Weiwei Guo ^{b, *,} ,
Jie Zhang ^{a, *,}

a.
School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China
b.
Center of Advanced Pharmaceuticals and Biomaterials, State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, China

guoweiwei@cpu.edu.cn

zhj8623@mail.xjtu.edu.cn

Received Date: 11 August 2023
Revised Date: 4 October 2023
Accepted Date: 6 October 2023
Available Online: 14 October 2023

Figures(3)

Tumor vascular normalization has emerged as a promising strategy for synergistic therapy recently. Based on the strategy of “fluorescence turn on-controllable release”, a novel bifunctional candidate was constructed based on previous developed vascular normalization inducer QDAU5, which could self-assemble to form functional enzyme infrared QDAU5 nanoparticles (FEIRQ NPs). Subsequently, biological evaluation demonstrated that the FEIRQ NPs could induce ferroptosis, endoplasmic reticulum stress, and antigen preconditioning and maturation of dendritic cells and CD8⁺ T cells, leading to excellent antitumor efficacy in the absence of cytotoxic drugs. Additionally, FEIRQ NPs show high fluorescence intensity upon exposure to the β-galactosidase (β-Gal) enzyme expressed in ovarian cancer, enabling real-time monitoring of therapeutic effects. Overall, our findings suggest a prospering strategy to early diagnosis and efficient therapy for ovarian cancer without cytotoxicity.
- Tumor vasculature normalization,
- Diagnosis and treatment,
- Cytotoxicity,
- Depleting glutathione,
- Ferroptosis,
- Immune activation
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