Citation: Jin Wang, Xiaoyan Pan, Junyu Zhang, Qingqing Zhang, Yanchen Li, Weiwei Guo, Jie Zhang. Active molecule-based theranostic agents for tumor vasculature normalization and antitumor efficacy[J]. Chinese Chemical Letters, ;2024, 35(8): 109187. doi: 10.1016/j.cclet.2023.109187 shu

Active molecule-based theranostic agents for tumor vasculature normalization and antitumor efficacy

Jin Wang ^{a, 1} ,
Xiaoyan Pan ^{a, 1} ,
Junyu Zhang ^a ,
Qingqing Zhang ^a ,
Yanchen Li ^a ,
Weiwei Guo ^{b, *,} ,
Jie Zhang ^{a, *,}

a.
School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China
b.
Center of Advanced Pharmaceuticals and Biomaterials, State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, China

guoweiwei@cpu.edu.cn

zhj8623@mail.xjtu.edu.cn

Received Date: 11 August 2023
Revised Date: 4 October 2023
Accepted Date: 6 October 2023
Available Online: 14 October 2023

Figures(3)

Tumor vascular normalization has emerged as a promising strategy for synergistic therapy recently. Based on the strategy of “fluorescence turn on-controllable release”, a novel bifunctional candidate was constructed based on previous developed vascular normalization inducer QDAU5, which could self-assemble to form functional enzyme infrared QDAU5 nanoparticles (FEIRQ NPs). Subsequently, biological evaluation demonstrated that the FEIRQ NPs could induce ferroptosis, endoplasmic reticulum stress, and antigen preconditioning and maturation of dendritic cells and CD8⁺ T cells, leading to excellent antitumor efficacy in the absence of cytotoxic drugs. Additionally, FEIRQ NPs show high fluorescence intensity upon exposure to the β-galactosidase (β-Gal) enzyme expressed in ovarian cancer, enabling real-time monitoring of therapeutic effects. Overall, our findings suggest a prospering strategy to early diagnosis and efficient therapy for ovarian cancer without cytotoxicity.
- Tumor vasculature normalization,
- Diagnosis and treatment,
- Cytotoxicity,
- Depleting glutathione,
- Ferroptosis,
- Immune activation
1. [1]
  S.F. Wen, K. Zhang, Y. Li, et al., Chin. Chem. Lett. 31 (2020) 3153–3157. doi: 10.1016/j.cclet.2020.03.077
2. [2]
  S. Luo, C. Liang, Q. Zhang, P. Zhang, Chin. Chem. Lett. 34 (2023) 107666. doi: 10.1016/j.cclet.2022.07.009
3. [3]
  G.S. Xie, L. Zhu, Y.Y. Song, et al., Chin. Chem. Lett. 32 (2021) 2164–2168. doi: 10.1016/j.cclet.2020.11.064
4. [4]
  Y.L. Song, H.Q. Jing, L.B. Vong, et al., Chin. Chem. Lett. 33 (2022) 1705–1717. doi: 10.1016/j.cclet.2021.10.055
5. [5]
  Y. Huang, B.Y.S. Kim, C.K. Chan, et al., Nat. Rev. Immunol. 18 (2018) 195–203. doi: 10.1038/nri.2017.145
6. [6]
  J. Ma, D.J. Waxman, Mol. Cancer Ther. 7 (2008) 3670–3684. doi: 10.1158/1535-7163.MCT-08-0715
7. [7]
  W. Li, Y.Y. Quan, Y. Li, et al., Cancer Manag. Res. 10 (2018) 4163–4172. doi: 10.2147/cmar.s174712
8. [8]
  M. Chen, Y. Xie, Q. Luo, et al., Chin. Chem. Lett. 34 (2023) 107744. doi: 10.1016/j.cclet.2022.107744
9. [9]
  C. Yang, B.R. Xia, Z.C. Zhang, et al., Front. Immunol. 11 (2020) 77869.
10. [10]
  J. Rais, A. Jafri, S. Siddiqui, et al., Front. Biosci. 9 (2017) 67–75. doi: 10.2741/e786
11. [11]
  L. Feeney, I.J. Harley, W.G. McCluggage, et al., World J. Clin. Oncol. 11 (2020) 868–889.
12. [12]
  R. McCorkle, J. Pasacreta, S.T. Tang, Holist. Nurs. Pract. 17 (2003) 300–308. doi: 10.1097/00004650-200311000-00005
13. [13]
  N. Bharwani, R.H. Reznek, A.G. Rockall, Eur. J. Radiol. 78 (2011) 41–51. doi: 10.1016/j.ejrad.2010.11.039
14. [14]
  K.A. Kujawa, K.M. Lisowska, Postepy Hig. Med. Dosw. 69 (2015) 1275–1290. doi: 10.5604/17322693.1184451
15. [15]
  Z. Wang, F. Meng, Z. Zhong, Adv. Drug Deliv. Rev. 178 (2021) 13969–13981. doi: 10.1039/d1nj03122h
16. [16]
  T. Kaur, R.A. Slavcev, S.D. Wettig, Curr. Gene Ther. 9 (2009) 434–458. doi: 10.2174/156652309790031148
17. [17]
  K. Itahana, J. Campisi, G.P. Dimri, Methods Mol. Biol. 371 (2007) 21–31. doi: 10.1007/978-1-59745-361-5_3
18. [18]
  B.Y. Lee, J.A. Han, J.S. Im, et al., Aging Cell 5 (2006) 187–195. doi: 10.1111/j.1474-9726.2006.00199.x
19. [19]
  G. Jannone, M. Rozzi, M. Najimi, et al., J. Histochem. Cytochem. 68 (2020) 269–278. doi: 10.1369/0022155420913534
20. [20]
  F. Fan, L. Zhang, X. Zhou, et al., J. Mater. Chem. B 9 (2021) 170–175. doi: 10.1039/d0tb02269a
21. [21]
  F. Mustafa, S. Liebich, S. Andreescu, Anal. Chim. Acta 1186 (2021) 39129–39137.
22. [22]
  P. Uruski, A. Sepetowska, C. Konieczna, et al., Cell. Mol. Biol. Lett. 26 (2021) 54–58. doi: 10.1186/s11658-021-00298-1
23. [23]
  P. Uruski, J. Mikuła-Pietrasik, E. Naumowicz, et al., Biomedicines 9 (2021) 30–39. doi: 10.3390/biomedicines9010030
24. [24]
  X. Li, Y. Pan, H. Chen, et al., Anal. Chem. 92 (2020) 5772–5779. doi: 10.1021/acs.analchem.9b05121
25. [25]
  L. Zhang, Y. Shan, X. Ji, et al., Oncotarget 8 (2017) 104745–104760. doi: 10.18632/oncotarget.20065
26. [26]
  Y.Y. Shan, J.F. Wang, R. Si, et al., Bioorg. Chem. 108 (2021) 04551.
27. [27]
  P. Liang, X. Huang, Y. Wang, et al., ACS Nano 12 (2018) 11446–11457. doi: 10.1021/acsnano.8b06478
28. [28]
  Z. Zhou, H. Liang, R. Yang, et al., Angew. Chem. Int. Ed. 61 (2022) e202202843. doi: 10.1002/anie.202202843
1. [1]
  Lin Li , Bingjun Sun , Jin Sun , Lin Chen , Zhonggui He . Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109538-. doi: 10.1016/j.cclet.2024.109538
2. [2]
  Guanghui Lin , Jieyao Chen , Xiaojia Liu , Yitong Lin , Xudong Zhu , Guotao Yuan , Bowen Yang , Shuanshuan Guo , Yue Pan , Jianhua Zhou . Sustained modulation of tumor microenvironment via sorafenib-loaded mesoporous ferromanganese nanozymes for enhanced apoptosis-ferroptosis cancer therapy. Chinese Chemical Letters, 2025, 36(8): 111018-. doi: 10.1016/j.cclet.2025.111018
3. [3]
  Chanqi Ye , Jia Zhang , Jie Shen , Ruyin Chen , Qiong Li , Peng Zhao , Dong Chen , Jian Ruan . Attractive Pickering emulsion gel loaded with oxaliplatin and lactate dehydrogenase inhibitor increases the anti-tumor effect in hepatocellular carcinoma. Chinese Chemical Letters, 2025, 36(7): 110519-. doi: 10.1016/j.cclet.2024.110519
4. [4]
  Weiqun Li , Ming-Jie Dong , Haibing Dai , Shanming Lu , Ran Luo , Jiahui Cao , Fan Zhang , Lin Mei , Jianbo Yu . Application of mitochondrial miRNA-204 nanoprobes in Alzheimer's disease treatment by clearing reactive oxygen species-mediated autophagy. Chinese Chemical Letters, 2025, 36(8): 110614-. doi: 10.1016/j.cclet.2024.110614
5. [5]
  Yanjun Cai , Yong Jiang , Yu Chen , Erzhuo Cheng , Yuan Gu , Yuwei Li , Qianqian Liu , Jian Zhang , Jifang Liu , Shisong Han , Bin Yang . Amplifying STING activation and immunogenic cell death by metal-polyphenol coordinated nanomedicines for enhanced cancer immunotherapy. Chinese Chemical Letters, 2025, 36(5): 110437-. doi: 10.1016/j.cclet.2024.110437
6. [6]
  Jiangshan Xu , Weifei Zhang , Zhengwen Cai , Yong Li , Long Bai , Shaojingya Gao , Qiang Sun , Yunfeng Lin . Tetrahedron DNA nanostructure/iron-based nanomaterials for combined tumor therapy. Chinese Chemical Letters, 2024, 35(11): 109620-. doi: 10.1016/j.cclet.2024.109620
7. [7]
  Zhendong Liu , Sainan Liu , Bin Liu , Qi Meng , Meng Yuan , Chunzheng Yang , Yulong Bian , Ping'an Ma , Jun Lin . Fe(Ⅲ)-juglone nanoscale coordination polymers for cascade chemodynamic therapy through synergistic ferroptosis and apoptosis strategy. Chinese Chemical Letters, 2024, 35(11): 109626-. doi: 10.1016/j.cclet.2024.109626
8. [8]
  Yuequan Wang , Congtian Wu , Chengcheng Feng , Qin Chen , Zhonggui He , Shenwu Zhang , Cong Luo , Jin Sun . Spatiotemporally-controlled supramolecular hybrid nanoassembly enabling ferroptosis-augmented photodynamic immunotherapy of cancer. Chinese Chemical Letters, 2025, 36(3): 109902-. doi: 10.1016/j.cclet.2024.109902
9. [9]
  Yan Gao , Zi-Lin Song , Shuang Yu , Xiu-Li Zhao , Da-Wei Chen , Ming-Xi Qiao . Enhanced ferroptosis by a nanoparticle mimicking hemoglobin coordinate pattern with self-supplying hydrogen peroxide. Chinese Chemical Letters, 2025, 36(5): 110097-. doi: 10.1016/j.cclet.2024.110097
10. [10]
  Quan Lu , Lulu Zhang , Zihan Chen , Jiajia Lv , Jie Gao , Xinmin Li , Hongyu Li , Wen Shi , Xiaohua Li , Huimin Ma , Zeli Yuan . A lipid droplet-targeting fluorescence probe for monitoring of lipid peroxidation in ferroptosis and non-alcoholic fatty liver disease. Chinese Chemical Letters, 2025, 36(8): 110620-. doi: 10.1016/j.cclet.2024.110620
11. [11]
  Zheng-Biao Zou , Tai-Zong Wu , Chun-Lan Xie , Yuan Wang , Yan Li , Gang Zhang , Rong Chao , Lian-Zhong Luo , Li-Sheng Li , Xian-Wen Yang . neo-Dicitrinols A–C: Unprecedented PKS-NRPS hybrid citrinin dimers with ferroptosis inhibitory activity from the deep-sea-derived Penicillium citrinum W22. Chinese Chemical Letters, 2024, 35(12): 109723-. doi: 10.1016/j.cclet.2024.109723
12. [12]
  Ke Wu , Xiuqin Ruan , Shuolei Jia , Enyuan Wang , Qingfa Zhou . DABCO-catalyzed [3+4] annulations of Schiff bases with α-substituted allenes: Construction of functionalized benzazepine derivatives. Chinese Chemical Letters, 2025, 36(7): 110646-. doi: 10.1016/j.cclet.2024.110646
13. [13]
  Chuan Li , Yangyang Han , Yanan Zhai , Ke Li , Xingzhong Liu , Zhuan Zhang , Cai Jia , Yongsheng Che . Phomaketals A and B, pentacyclic meroterpenoids from a eupC overexpressed mutant strain of Phoma sp.. Chinese Chemical Letters, 2024, 35(7): 109019-. doi: 10.1016/j.cclet.2023.109019
14. [14]
  Yongjian Liu , Cen Liu , Haitao Guo , Jinchai Qi , Heng Chen , Yuping Yang , Tao Ma , Yonggang Liu . Alkaloids peganumiums A–C from Peganum harmala L., with two novel long conjugated structures. Chinese Chemical Letters, 2025, 36(8): 110558-. doi: 10.1016/j.cclet.2024.110558
15. [15]
  Xing Tian , Di Wu , Wanheng Wei , Guifu Dai , Zhanxian Li , Benhua Wang , Mingming Yu . A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death, inflammation and fatty liver tissue. Chinese Chemical Letters, 2024, 35(6): 108912-. doi: 10.1016/j.cclet.2023.108912
16. [16]
  Hui Zhang , Rong Feng , Wanyi Yu , Hongbei Wei , Tianhong Wu , Peng Zhang , Wenhai Bian , Xin Li , Di Gao , Guojun Weng , Zhe Yang , Tony D. James , Xiaolong Sun . Evaluating the global thiols redox state in living cells using a reducing sulfur species responsive fluorescence switching platform. Chinese Chemical Letters, 2025, 36(4): 110528-. doi: 10.1016/j.cclet.2024.110528
17. [17]
  Jiayu Zeng , Minhui Liu , Ting Yang , Jia Huang , Songjiao Li , Wanting Zhang , Dan Cheng , Longwei He , Jia Zhou . Two-dimensional design strategy to construct smart dual-responsive fluorescent probe for the precise tracking of ischemic stroke. Chinese Chemical Letters, 2025, 36(5): 110166-. doi: 10.1016/j.cclet.2024.110166
18. [18]
  Peide Zhu , Yangjia Liu , Yaoyao Tang , Siqi Zhu , Xinyang Liu , Lei Yin , Quan Liu , Zhiqiang Yu , Quan Xu , Dixian Luo , Juncheng Wang . Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment. Chinese Chemical Letters, 2024, 35(4): 108689-. doi: 10.1016/j.cclet.2023.108689
19. [19]
  Cheng-Zhe Gao , Hao-Ran Jia , Tian-Yu Wang , Xiao-Yu Zhu , Xiaofeng Han , Fu-Gen Wu . A dual drug-loaded tumor vasculature-targeting liposome for tumor vasculature disruption and hypoxia-enhanced chemotherapy. Chinese Chemical Letters, 2025, 36(1): 109840-. doi: 10.1016/j.cclet.2024.109840
20. [20]
  Zhe-Han Yang , Jie Yin , Lei Xin , Yuanfang Li , Yijie Huang , Ruo Yuan , Ying Zhuo . Research advancement of DNA-based intelligent hydrogels: Manufacture, characteristics, application of disease diagnosis and treatment. Chinese Chemical Letters, 2024, 35(10): 109558-. doi: 10.1016/j.cclet.2024.109558

Get Citation

PDF

XML

Metrics

PDF Downloads(4)
Abstract views(1092)
HTML views(26)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142