Citation: Chenchen Xie, Jun Liao, Ning Zhang, Yuhan Sun, Yi Li, Liyan Xiong, Yingnan Zhang, Xiaoyan Liu, Wei Su, Heming Chen, Ping Zeng, Xiaoqing Zhang, Ying Lu, Tingfang Wang, Chuan Zhang. Advanced nano drug delivery systems for neuroprotection against ischemic stroke[J]. Chinese Chemical Letters, ;2024, 35(2): 109149. doi: 10.1016/j.cclet.2023.109149 shu

Advanced nano drug delivery systems for neuroprotection against ischemic stroke

Chenchen Xie ^{a, 1} ,
Jun Liao ^{a, 1} ,
Ning Zhang ^{c, 1} ,
Yuhan Sun ^b ,
Yi Li ^a ,
Liyan Xiong ^a ,
Yingnan Zhang ^b ,
Xiaoyan Liu ^a ,
Wei Su ^a ,
Heming Chen ^a ,
Ping Zeng ^d ,
Xiaoqing Zhang ^{c, *,} ,
Ying Lu ^{b, *,} ,
Tingfang Wang ^{a, *,} ,
Chuan Zhang ^{a, *,}

a.
Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai 200444, China
b.
Department of Pharmaceutical Science, School of Pharmacy, Naval Medical University, Shanghai 200433, China
c.
Department of pharmacy, the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China
d.
School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200040, China

Received Date: 16 July 2023
Revised Date: 21 September 2023
Accepted Date: 25 September 2023
Available Online: 27 September 2023

Figures(5)

Ischemic stroke (IS) represents a significant threat to brain health due to its elevated mortality and disability rates. The efficacy of small-molecule neuroprotective agents has been impeded by challenges associated with traversing the blood-brain barrier (BBB) and limited bioavailability. Conversely, advanced nano drug delivery systems hold promise for overcoming these obstacles by facilitating efficient transportation across the BBB and maintaining optimal drug concentrations. This review aims to explore advanced neuroprotective nano drug delivery systems as a means of effectively administering neuroprotective agents to the brain using pharmaceutical approaches in the treatment of IS. By examining these systems, researchers and clinicians can gain valuable insights and innovative concepts, illuminating the potential of advanced neuroprotective nano drug delivery systems. Leveraging these advancements can drive the progress of pioneering and efficacious therapeutic interventions for IS.
- Target,
- Blood–brain barrier,
- Ischemic stroke,
- Nano drug delivery,
- Neuroprotection
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沈阳化工大学材料科学与工程学院沈阳 110142