Citation: Xin Zhang, Junyu Chen, Xiang Pei, Linxin Yang, Liang Wang, Luona Chen, Guangmei Yang, Xibo Pei, Qianbing Wan, Jian Wang. Drug-loading ZIF-8 for modification of microporous bone scaffold to promote vascularized bone regeneration[J]. Chinese Chemical Letters, ;2024, 35(6): 108889. doi: 10.1016/j.cclet.2023.108889 shu

Drug-loading ZIF-8 for modification of microporous bone scaffold to promote vascularized bone regeneration

Xin Zhang ^{a, b} ,
Junyu Chen ^{a, b} ,
Xiang Pei ^a ,
Linxin Yang ^{a, b} ,
Liang Wang ^{a, b} ,
Luona Chen ^{a, b} ,
Guangmei Yang ^{a, b} ,
Xibo Pei ^{a, b} ,
Qianbing Wan ^{a, b, *,} ,
Jian Wang ^{a, b, *,}

a.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chengdu 610041, China
b.
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

champion@scu.edu.cn

ferowang@hotmail.com

Received Date: 16 June 2023
Revised Date: 28 July 2023
Accepted Date: 3 August 2023
Available Online: 6 August 2023

Figures(4)

Surface modification of microporous bone scaffolds using nanoparticles has been broadly studied in bone tissue engineering. Aiming at improving vascularized bone regeneration (VBR), zeolitic imidazolate framework-8 (ZIF-8) was encapsulated with dimethyloxallyl glycine (DMOG) and the drug-carrying nanoparticles (D@Z) could be uniformly coated onto the surface of the bone scaffold. The osteogenic and angiogenic actions of D@Z are closely correlated with the amount of slowly released DMOG, and in general, exhibited a favorable association. Then, the D7.5@Z group, which showed the greatest capacity to induce in vitro osteogenesis–angiogenesis coupling, was utilized for surface modification of the bone scaffold. Biological processes including phosphate-containing compound metabolic process, cell differentiation, cell proliferation and cell motility might contribute to enhanced ability to induce VBR by the coated scaffold and signaling pathways such as Rap1, Ras, phosphatidylinositol 3-kinase/protein kinase B (PI3K-AKT) and vascular endothelial growth factor (VEGF) signaling pathways participated in these processes. Finally, as depicted by in vitro real time-polymerase chain reaction (RT-PCR), Western blot (WB) and in vivo cranial bone defect model, the microporous scaffold coated with nano-D7.5@Z greatly promoted VBR. To conclude, nano-D@Z has significant promise for practical application in modification of microporous bone scaffolds to enhance VBR, and DMOG loading quantity has a beneficial influence on D@Z to improve osteogenesis–angiogenesis coupling.
- Drug-loading nanoparticles,
- Surface coating,
- Microporous bone scaffold,
- Vascularization,
- bone regeneration
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