Citation: Maojie Zhang, Qiang Cao, Yuming Yuan, Xiaohan Guo, Dawei Pan, Rui Xie, Xiaojie Ju, Zhuang Liu, Wei Wang, Liangyin Chu. Functional nanoemulsions: Controllable low-energy nanoemulsification and advanced biomedical application[J]. Chinese Chemical Letters, ;2024, 35(2): 108710. doi: 10.1016/j.cclet.2023.108710 shu

Functional nanoemulsions: Controllable low-energy nanoemulsification and advanced biomedical application

Maojie Zhang ^a ,
Qiang Cao ^b ,
Yuming Yuan ^a ,
Xiaohan Guo ^a ,
Dawei Pan ^{b, c} ,
Rui Xie ^{b, c} ,
Xiaojie Ju ^{b, c} ,
Zhuang Liu ^{b, c} ,
Wei Wang ^{b, c, *,} ,
Liangyin Chu ^{b, c}

a.
College of Engineering, Sichuan Normal University, Chengdu 610101, China
b.
School of Chemical Engineering, Sichuan University, Chengdu 610065, China
c.
State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China

wangwei512@scu.edu.cn

Received Date: 23 March 2023
Revised Date: 14 June 2023
Accepted Date: 19 June 2023
Available Online: 22 June 2023

Figures(9)

Nanoemulsions are widely used as advanced pharmaceutical delivery systems in biomedical field, due to their high encapsulation efficiency and good therapy efficacy. Nanoemulsification techniques that produce nanoemulsions with controllable sizes and compositions are promising for creating advanced nanoemulsion systems for pharmaceutical delivery. This review summarizes recent advances on low-energy emulsification techniques for producing nanoemulsions, and the use of these nanoemulsions as advanced pharmaceutical delivery systems and as templates to create drug-loaded functional particles for biomedical application. First, nanoemulsification techniques that utilize elaborate interfacial physics/chemistry and micro-/nano-fluidics, featured with relatively-low energy input, to produce nanoemulsions with controllable sizes and compositions, are introduced. Uses of these nanoemulsions to create nanoemulsion-incorporated milli-particles, drug-loaded nanoparticles and nanoparticle-incorporated microparticles with sizes ranging from several millimeters to sub-10 nm are emphasized. Flexible and efficient use of the nanoemulsions, functional nanoparticles and milli-/micro-particles integrated with nanoemulsions or nanoparticles for advanced pharmaceutical delivery in biomedical field are highlighted, with focus on how the interplay between their sizes and compositions achieve desired pharmaceutical-delivery performances. Finally, perspectives on further advances on the controllable production of nanoemulsions are provided.
- Nanoemulsions,
- Interfaces,
- Drug delivery,
- Template synthesis,
- Nanoparticles
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沈阳化工大学材料科学与工程学院沈阳 110142