Citation: Zhaoyue Lv, Mengxue Huang, Peiran Li, Mengdi Xu, Chi Yao, Dayong Yang. Hybridization chain reaction-based DNA nanomaterials for biosensing, bioimaging and therapeutics[J]. Chinese Chemical Letters, ;2024, 35(2): 108601. doi: 10.1016/j.cclet.2023.108601 shu

Hybridization chain reaction-based DNA nanomaterials for biosensing, bioimaging and therapeutics

Zhaoyue Lv ^{a, 1} ,
Mengxue Huang ^{a, 1} ,
Peiran Li ^a ,
Mengdi Xu ^a ,
Chi Yao ^{a, b, *,} ,
Dayong Yang ^{a, b, *,}

a.
Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), Institute of Biomolecular and Biomedical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China
b.
Zhejiang Institute of Tianjin University, Ningbo 315201, China

chi.yao@tju.edu.cn

dayong.yang@tju.edu.cn

Received Date: 5 March 2023
Revised Date: 19 May 2023
Accepted Date: 22 May 2023
Available Online: 24 May 2023

Figures(7)

DNA nanomaterials hold great promise in biomedical fields due to its excellent sequence programmability, molecular recognition ability and biocompatibility. Hybridization chain reaction (HCR) is a simple and efficient isothermal enzyme-free amplification strategy of DNA, generating nicked double helices with repeated units. Through the design of HCR hairpins, multiple nanomaterials with desired functions are assembled by DNA, exhibiting great potential in biomedical applications. Herein, the recent progress of HCR-based DNA nanomaterials for biosensing, bioimaging and therapeutics are summarized. Representative works are exemplified to demonstrate how HCR-based DNA nanomaterials are designed and constructed. The challenges and prospects of the development of HCR-based DNA nanomaterials are discussed. We envision that rationally designing HCR-based DNA nanomaterials will facilitate the development of biomedical applications.
- DNA nanotechnology,
- Hybridization chain reaction,
- DNA nanomaterials,
- Biosensing,
- Bioimaging,
- Therapeutics
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