Citation: Xin Wang, Zhichuan Wang, Zhenjian Li, Kai Sun. Trifluoromethoxylation/trifluoromethylthiolation/trifluoro-methylselenolation strategy for the construction of heterocycles[J]. Chinese Chemical Letters, ;2023, 34(5): 108045. doi: 10.1016/j.cclet.2022.108045 shu

Trifluoromethoxylation/trifluoromethylthiolation/trifluoro-methylselenolation strategy for the construction of heterocycles

Xin Wang ^{a, 1} ,
Zhichuan Wang ^{a, 1} ,
Zhenjian Li ^b ,
Kai Sun ^{a, *,}

a.
College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China
b.
State Key Laboratory of Tree Genetics and Breeding, Research Institute of Forestry, Chinese Academy of Forestry, Beijing 100091, China

Author Bio: Xin Wang was born in Heilongjiang, China and received her MS degree from Northeast Normal University in 2012. In July 2013, she joined the College of Chemistry and Chemical Engineering, Anyang Normal University. In 2019, she pursued her Ph.D. degree in Zhengzhou University. Her research program is drug design, structural identification and structural modification of natural products
Zhichuan Wang was born in Jiangsu, China in 1997. In 2015, he began his studies at the School of Pharmacy, Jilin Medical University. In 2020, he pursued his MS degree in YanTai University under the direction of associate professor Kai Sun. His current research is focused on radical CH functionalization
Zhenjian Li, Doctor, Forestry Research Institute, China Academy of Forestry, Associate researcher, Master's supervisor. He mainly engage in the research on the components and functions of medicinal Dendrobium; Collection and development of ornamental and medicinal Dendrobium germplasm resources
Kai Sun was born in Shanxi, China in 1983. He received his Ph.D. degree in organic chemistry from Northeast Normal University in 2013 under the supervision of Prof. Qian Zhang. In July 2020, he joined the College of Chemistry and Chemical Engineering, YanTai University, where he is an professor. His current research is focused on CH functionalization, radical chemistry and organic selenium chemistry

sunk468@nenu.edu.cn

Received Date: 31 October 2022
Revised Date: 3 December 2022
Accepted Date: 5 December 2022
Available Online: 8 December 2022

Figures(39)

The XCF₃ groups (X = O, S, Se) play an increasingly important role in modern organic chemistry due to their unique electronegativity, lipophilic nature, metabolic stability, and bioavailability. Heterocyclic compounds are important scaffolds in many bioactive compounds and drugs. The incorporation of XCF₃ groups into heterocyclic compounds can change their physicochemical and biological properties, which injects new vitality into the application of heterocyclic compounds in many fields such as organic chemistry, the pharmaceutical chemistry, and life sciences. In this paper, the recent progress in the synthesis of F₃CX-containing heterocycles is reviewed, and the application scope and mechanism of some reactions are discussed.
- Trifluoromethoxylation,
- Trifluoromethylthiolation,
- Trifluoromethylselenolation,
- Cyclization
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