Citation: Xiaobing Chen, Huan Yang, Xu Song, Hong Liang, Yu Wei, Jiao Lu, Matthias Barz, Rongrong Jin, Yu Nie. Integrated and dual-responsive lipopeptide nanovector with parallel effect to tumor and micro-environment regulation by efficient gene and drug co-delivery[J]. Chinese Chemical Letters, ;2023, 34(5): 107753. doi: 10.1016/j.cclet.2022.107753 shu

Integrated and dual-responsive lipopeptide nanovector with parallel effect to tumor and micro-environment regulation by efficient gene and drug co-delivery

Xiaobing Chen ^{a, 1} ,
Huan Yang ^{a, 1} ,
Xu Song ^{a, 1} ,
Hong Liang ^{a, c} ,
Yu Wei ^a ,
Jiao Lu ^a ,
Matthias Barz ^b ,
Rongrong Jin ^{a, *,} ,
Yu Nie ^{a, *,}

a.
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
b.
Leiden Academic Center for Drug Research (LACDR), Leiden University, Leiden 2333 CC, The Netherlands
c.
Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China

jinrr2015@scu.edu.cn

nie_yu@scu.edu.cn

Received Date: 20 April 2022
Revised Date: 13 August 2022
Accepted Date: 16 August 2022
Available Online: 24 August 2022

Figures(7)

The integrated lipopeptide (RVA)/gene complexes are fabricated with bi-directional regulation on tumor cells and micro-environment. After self-assembling and target coating modification, the poly(γ-glutamic acid) (γ-PGA)/RVA nano-vectors can sequentially respond to pH & redox stimuli, and guarantee efficient therapeutic gene delivery and control release of all-trans retinoic acid. The design provides a facile but promising strategy to treat refractory cancers.
- Gene delivery,
- Integrated co-delivery,
- Dual-responsive,
- Lipopeptide,
- Tumor micro-environment regulation
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