Citation: Qiang Zeng, Zhigang Liu, Ting Niu, Chuan He, Ying Qu, Zhiyong Qian. Application of nanotechnology in CAR-T-cell immunotherapy[J]. Chinese Chemical Letters, ;2023, 34(3): 107747. doi: 10.1016/j.cclet.2022.107747 shu

Application of nanotechnology in CAR-T-cell immunotherapy

Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

quying1988@126.com

zhiyongqian@scu.edu.cn

Received Date: 9 June 2022
Revised Date: 9 August 2022
Accepted Date: 12 August 2022
Available Online: 14 August 2022

Figures(7)

It is cellular immunotherapy for the tumor that the in vitro modified immunocytes from patients or donors are reinfused into patients to kill tumor cells. Chimeric antigen receptor T cell (CAR-T) therapy, one of the most successful and representative tumor cellular immunotherapies, is now the weapon for cancer after extensive research. Although CAR-T immunotherapy achieves success in treating relapsed/refractory hematological tumors, its drawbacks, including the poor effect in solid tumors, cytokine release syndrome (CRS) or CAR-T-related encephalopathy syndrome (CRES), on-target, off-tumor effect, and high cost, cannot be overlooked. Nanotechnology is advantageous in the construction of CARs, the transfection of T cells, the expansion, delivery, and antitumor effect of CAR-T cells, and the reduction of CAR-T therapy-associated toxicities. Currently, introducing nanotechnology into CAR-T immunotherapy has already been performed in numerous studies with highly promising results. In this review, we summarized the nanotechnologies used in CAR-T immunotherapy and discussed the challenges and directions of CAR-T immunotherapy combined with nanotechnologies in the future.
- CAR-T immunotherapy,
- Nanotechnology,
- Nanobody,
- Nanoparticle
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