Citation: Haixin Zhang, Jingrong Li, Jinguang Si, Chengya Dong, Qi Li, Meng Yu, Lingling Qin, Lingyu Li, Chenxu Zhao, Tao Zhang, Zhongmei Zou. Atramacronoids A−C, three eudesmanolide sesquiterpene-phenol hybrids with an unprecedented C−C linkage from the rhizomes of Atractylodes macrocephala[J]. Chinese Chemical Letters, ;2023, 34(1): 107743. doi: 10.1016/j.cclet.2022.107743 shu

Atramacronoids A−C, three eudesmanolide sesquiterpene-phenol hybrids with an unprecedented C−C linkage from the rhizomes of Atractylodes macrocephala

Haixin Zhang ^a ,
Jingrong Li ^{a, b} ,
Jinguang Si ^a ,
Chengya Dong ^c ,
Qi Li ^c ,
Meng Yu ^a ,
Lingling Qin ^a ,
Lingyu Li ^a ,
Chenxu Zhao ^{a, d} ,
Tao Zhang ^{a, *,} ,
Zhongmei Zou ^{a, *,}

a.
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
b.
Medical Sciences, Guizhou Medical University, Guiyang 550000, China
c.
China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100193, China
d.
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450000, China

tzhang@implad.ac.cn

zmzou@implad.ac.cn

Received Date: 30 May 2022
Revised Date: 7 August 2022
Accepted Date: 10 August 2022
Available Online: 15 August 2022

Figures(8)

Three eudesmanolide sesquiterpene-phenol hybrids, atramacronoids A−C (1−3), featuring an unusual 6/6/5/5/6 skeleton furnished by forming an unexpected C-8−C-16 linkage, were obtained from the rhizomes of Atractylodes macrocephala. Their structures and absolute configurations were elucidated by spectroscopic data analysis, chemical calculations, combined with X-ray diffractions. The plausible biosynthetic pathways for compounds 1−3 are proposed. Surprisingly, compound 1 exhibited cytotoxicity against SGC-7901 cells by inducing cells apoptosis, which might relate to the promotion of synthesis of neutrophil elastase.
- Atractylodes macrocephala,
- Compositae,
- Sesquiterpene-phenol hybrids,
- Anti-cancer,
- Neutrophil elastase
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沈阳化工大学材料科学与工程学院沈阳 110142