Citation: Jinyu Hao, Cui Zhang, Chenxi Feng, Qian Wang, Zhong-Yi Liu, Yan Li, Jianshuai Mu, En-Cui Yang, Yan Wang. An ultra-highly active nanozyme of Fe,N co-doped ultrathin hollow carbon framework for antibacterial application[J]. Chinese Chemical Letters, ;2023, 34(3): 107650. doi: 10.1016/j.cclet.2022.06.073 shu

An ultra-highly active nanozyme of Fe,N co-doped ultrathin hollow carbon framework for antibacterial application

Jinyu Hao ^a ,
Cui Zhang ^c ,
Chenxi Feng ^a ,
Qian Wang ^a ,
Zhong-Yi Liu ^a ,
Yan Li ^a ,
Jianshuai Mu ^{a, *,} ,
En-Cui Yang ^{a, *,} ,
Yan Wang ^{b, *,}

a.
College of Chemistry, Tianjin Key Laboratory of Structure and Performance for Functional Molecules, Tianjin Normal University, Tianjin 300387, China
b.
School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China
c.
School of food and Bioengineering, Xuzhou University of Technology, Xuzhou 221018, China

hxxymujianshuai@tjnu.edu.cn

encui_yang@163.com

wangy_msn@hit.edu.cn

Received Date: 8 March 2022
Revised Date: 23 June 2022
Accepted Date: 27 June 2022
Available Online: 30 June 2022

Figures(4)

In recent years, nanozymes have received more and more attention, but the low activity limits the development of nanozymes. Therefore, the design and development of efficient nanozymes is still a major challenge for researchers. Herein, the Fe,N co-doped ultrathin hollow carbon framework (Fe,N-UHCF) exhibit ultra-high peroxidase-like activity. The specific activity of Fe,N-UHCF nanozyme is as high as 36.6 U/mg, which is much higher than almost all of other reported nanozymes. In practical applications, the Fe,N-UHCF show good antibacterial effects.
- Peroxidase-like,
- Nanozyme,
- Ultra-highly active,
- Specific activity,
- Antibacterial
1. [1]
  Y.H. Hu, X.J.J. Gao, Y.Y. Zhu, et al., Chem. Mater. 30 (2018) 6431–6439. doi: 10.1021/acs.chemmater.8b02726
2. [2]
  C. Zhao, C. Xiong, X.K. Liu, et al., Chem. Commun. 55 (2019) 2285–2288. doi: 10.1039/c9cc00199a
3. [3]
  Y.P. Chen, Y.L. Xianyu, M.L. Dong, et al., Anal. Chem. 90 (2018) 6906–6912. doi: 10.1021/acs.analchem.8b01138
4. [4]
  E.N. Mirts, I.D. Petrik, P. Hosseinzadeh, et al., Science 361 (2018) 1098–1101. doi: 10.1126/science.aat8474
5. [5]
  Y.B. Zhou, B.W. Liu, R.H. Yang, et al., Bioconjugate Chem. 28 (2017) 2903–2909. doi: 10.1021/acs.bioconjchem.7b00673
6. [6]
  F.M. Wang, Y. Zhang, Z.W. Liu, et al., Nanoscale 12 (2020) 14465–14471. doi: 10.1039/d0nr03217d
7. [7]
  Y.H. Lin, J.S. Ren, X.G. Qu, Acc. Chem. Res. 47 (2014) 1097–1105. doi: 10.1021/ar400250z
8. [8]
  X.L. Zhang, G.L. Li, D. Wu, et al., Biosens. Bioelectron. 137 (2019) 178–198. doi: 10.1504/ijics.2019.098205
9. [9]
  J.J.X. Wu, X.Y. Wang, Q. Wang, et al., Chem. Soc. Rev. 48 (2019) 1004–1076. doi: 10.1039/c8cs00457a
10. [10]
  M.M. Liang, X.Y. Yan, Acc. Chem. Res. 52 (2019) 2190–2200. doi: 10.1021/acs.accounts.9b00140
11. [11]
  L.L. Zeng, Y.X. Han, Z.W. Chen, et al., Adv. Sci. 8 (2021) 2101184. doi: 10.1002/advs.202101184
12. [12]
  W.J. Ma, Y.F. Xue, S.Y. Guo, et al., Chem. Commun. 56 (2020) 5115–5118. doi: 10.1039/D0CC01840F
13. [13]
  D.M. He, M.M. Yan, P.J. Sun, et al., Chin. Chem. Lett. 32 (2021) 2994–3006. doi: 10.1016/j.cclet.2021.03.078
14. [14]
  Z.J. Zhang, L.M. Bragg, M.R. Servos, et al., Chin. Chem. Lett. 30 (2019) 1655–1658. doi: 10.1016/j.cclet.2019.05.062
15. [15]
  W.H. Chen, M. Vazquez-Gonzalez, A. Kozell, et al., Small 14 (2018) 1703149. doi: 10.1002/smll.201703149
16. [16]
  M.J. Lu, C. Wang, Y.Q. Ding, et al., Chem. Commun. 55 (2019) 14534–14537. doi: 10.1039/c9cc07408b
17. [17]
  L.Z. Gao, J. Zhuang, L. Nie, et al., Nat. Nanotechnol. 2 (2007) 577–583. doi: 10.1038/nnano.2007.260
18. [18]
  L. Han, H.J. Zhang, D.Y. Chen, et al., Adv. Funct. Mater. 28 (2018) 1800018. doi: 10.1002/adfm.201800018
19. [19]
  S.Q. Li, Y.J. Hou, Q.M. Chen, et al., ACS Appl. Mater. Interfaces 12 (2020) 2581–2590. doi: 10.1021/acsami.9b20275
20. [20]
  X.H. Niu, Q.R. Shi, W.L. Zhu, et al., Biosens. Bioelectron. 142 (2019) 111495. doi: 10.1016/j.bios.2019.111495
21. [21]
  Y.Y. Zhong, T.T. Wang, Z.T. Lao, et al., ACS Appl. Mater. Interfaces 13 (2021) 21680–21692. doi: 10.1021/acsami.1c00126
22. [22]
  L. Jiao, W.Q. Xu, Y. Zhang, et al., Nano Today 35 (2020) 100971. doi: 10.1016/j.nantod.2020.100971
23. [23]
  J.Q. Zhang, Y.F. Zhao, C. Chen, et al., J. Am. Chem. Soc. 141 (2019) 20118–20126. doi: 10.1021/jacs.9b09352
24. [24]
  L. Jiao, W.Q. Xu, H.Y. Yan, et al., Anal. Chem. 91 (2019) 11994–11999. doi: 10.1021/acs.analchem.9b02901
25. [25]
  L. Zhao, Y. Zhang, L.B. Huang, et al., Nat. Commun. 10 (2019) 1278. doi: 10.1038/s41467-019-09290-y
26. [26]
  Y.J. Sang, W. Li, H. Liu, et al., Adv. Funct. Mater. 29 (2019) 1900518. doi: 10.1002/adfm.201900518
27. [27]
  M.F. Huo, L.Y. Wang, H.X. Zhang, et al., Small 15 (2019) 1901834. doi: 10.1002/smll.201901834
28. [28]
  L.W. Wang, F.N. Gao, A.Z. Wang, et al., Adv. Mater. 32 (2020) 2005423. doi: 10.1002/adma.202005423
29. [29]
  F.F. Cao, L. Zhang, H. Wang, et al., Angew. Chem. Int. Ed. 58 (2019) 16236–16242. doi: 10.1002/anie.201908289
30. [30]
  H.J. Xiang, W. Feng, Y. Chen, Adv. Mater. 32 (2020) 1905994. doi: 10.1002/adma.201905994
31. [31]
  B.L. Xu, H. Wang, W.W. Wang, et al., Angew. Chem. Int. Ed. 58 (2019) 4911–4916. doi: 10.1002/anie.201813994
32. [32]
  W.X. Chen, J.J. Pei, C.T. He, et al., Angew. Chem. Int. Ed. 56 (2017) 16086–16090. doi: 10.1002/anie.201710599
33. [33]
  V. Kumar, H.C. Swart, O.M. Ntwaeaborwa, et al., Mater. Lett. 101 (2013) 57–60. doi: 10.1016/j.matlet.2013.03.073
34. [34]
  B. Jiang, D.M. Duan, L.Z. Gao, et al., Nat. Protoc. 13 (2018) 1506–1520. doi: 10.1038/s41596-018-0001-1
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