Citation: Xiaoyao Ma, Yiman Han, Kaixin Liu, Yongping Bai, He Gao, Yuanyuan Hou, Gang Bai. Chemical proteomics combined with metabonomics reveals berberine targets NDUFV1 of complex Ⅰ in the respiratory chain to regulate energy metabolism[J]. Chinese Chemical Letters, ;2023, 34(3): 107595. doi: 10.1016/j.cclet.2022.06.018 shu

Chemical proteomics combined with metabonomics reveals berberine targets NDUFV1 of complex Ⅰ in the respiratory chain to regulate energy metabolism

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300381, China

houyy@nankai.edu.cn

gangbai@nankai.edu.cn

Received Date: 26 January 2022
Revised Date: 6 June 2022
Accepted Date: 6 June 2022
Available Online: 13 June 2022

Figures(5)

Berberine (BBR) is the primary alkaloid compound of the heat-clearing traditional Chinese medicine Huanglian (Coptis chinensis) and exerts regulatory effects on energy metabolism. However, the specific targets and molecular mechanisms are not clear. In this paper, the BBR-affected energy metabolism pathway was screened by nontargeted metabolomics, and a BBR-derived photoaffinity labeled (PAL) probe was designed to identify potential targets via a chemical proteomics approach. NDUFV1, a subunit of complex Ⅰ on mitochondria, was identified as a potential target of BBR. In the respiratory chain, BBR suppressed the activity of complex Ⅰ, reduced the electrochemical potential in the mitochondrial intermembrane and inhibited the generation of ATP and heat via competitive binding with NDUFV1. The results illustrated the underlying mechanism of BBR in the downregulation of energy metabolism.
- Berberine,
- Photoaffinity labeled,
- Chemical proteomics,
- NDUFV1,
- Complex Ⅰ,
- Energy metabolism
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