Citation: Min Xu, Chuchu Ren, Yue Zhou, Zbynek Heger, Xiaoyang Liang, Vojtech Adam, Nan Li. Enhanced macrophage polarization induced by COX-2 inhibitor-loaded Pd octahedral nanozymes for treatment of atherosclerosis[J]. Chinese Chemical Letters, ;2023, 34(1): 107585. doi: 10.1016/j.cclet.2022.06.008 shu

Enhanced macrophage polarization induced by COX-2 inhibitor-loaded Pd octahedral nanozymes for treatment of atherosclerosis

Min Xu ^a ,
Chuchu Ren ^a ,
Yue Zhou ^a ,
Zbynek Heger ^b ,
Xiaoyang Liang ^a ,
Vojtech Adam ^{b, *,} ,
Nan Li ^{a, *,}

a.
School of Pharmaceutical Science and Technology, Tianjin University, Tainjin 300072, China
b.
Department of Chemistry and Biochemistry, Mendel University in Brno, Brno CZ-613 00, Czech Republic

vojtech.adam@mendelu.cz

linan1985@tju.edu.cn

Received Date: 12 November 2021
Revised Date: 1 June 2022
Accepted Date: 5 June 2022
Available Online: 10 June 2022

Figures(6)

Inhibition of foam cell formation is considered a promising treatment method for atherosclerosis, the leading cause of cardiovascular diseases worldwide. However, currently available therapeutic strategies have shown unsatisfactory clinical outcomes. Thus, herein, we design aloperine (ALO)-loaded and hyaluronic acid (HA)-modified palladium (Pd) octahedral nanozymes (Pd@HA/ALO) that can synergistically scavenge reactive oxygen species (ROS) and downregulate cyclooxygenase-2 (COX-2) expression to induce macrophage polarization, thus inhibiting foam cell formation to attenuate atherosclerosis. Due to the targeted effect of HA on stabilin-2 and CD44, which are overexpressed in atherosclerotic plaques, Pd@HA/ALO can actively accumulate in atherosclerotic plaques. Subsequently, the antioxidative effects of Pd octahedral nanozymes are mediated by their intrinsic superoxide dismutase- and catalase-like activities capable of effective scavenging of ROS. In addition, anti-inflammatory effects are mediated by controlled, on-demand near-infrared-triggered ALO release leading to inhibition of COX-2 expression. Importantly, the combined therapy can promote the polarization of macrophages to the M2 subtype by upregulating Arg-1 and CD206 expression and downregulating expression of TNF-α, IL-1β and IL-6, thereby inhibiting atherosclerosis-related foam cell formation. In conclusion, the presented in vitro and in vivo data demonstrate that Pd@HA/ALO enhanced macrophage polarization to reduce plaque formation, identifying an attractive treatment strategy for cardiovascular disease.
- Atherosclerosis,
- COX-2 inhibitor,
- Pd octahedral nanozyme,
- Macrophage polarization,
- Anti-inflammation,
- Antioxidation
1. [1]
  P. Libby, Arterioscler, Thromb., Vasc. Biol. 32 (2012) 2045-2051. doi: 10.1161/ATVBAHA.108.179705
2. [2]
  H. Hemingway, F.W. Asselbergs, J. Danesh, et al., Eur. Heart J. 39 (2018) 1481-1495. doi: 10.1093/eurheartj/ehx487
3. [3]
  Y. Song, H. Jing, L.B. Vong, J. Wang, N. Li, Chin. Chem. Lett. 33 (2022) 1705-1717. doi: 10.1016/j.cclet.2021.10.055
4. [4]
  P.D. Thompson, G. Panza, A. Zaleski, et al., J. Am. Coll. Cardiol. 67 (2016) 2395-2410. doi: 10.1016/j.jacc.2016.02.071
5. [5]
  R.J. Andrade, N. Chalasani, E.S. Björnsson, et al., Nat. Rev. Dis. Primers 5 (2019) 1-22. doi: 10.1038/s41572-018-0051-2
6. [6]
  Y. Sawayama, C. Shimizu, N. Maeda, et al., J. Am. Coll. Cardiol. 39 (2002) 610-616. doi: 10.1016/S0735-1097(01)01783-1
7. [7]
  S.R. Thomas, P.K. Witting, R. Stocker, et al., BioFactors 9 (1999) 207-224. doi: 10.1002/biof.5520090216
8. [8]
  S. Mora, J.A.E. Manson, JAMA Intern. Med. 176 (2016) 1195-1204. doi: 10.1001/jamainternmed.2016.2648
9. [9]
  M.E. Burleigh, V.R. Babaev, M.B. Patel, et al., Biochem. Pharmacol. 70 (2005) 334-342. doi: 10.1016/j.bcp.2005.04.044
10. [10]
  I. Tabas, K.E. Bornfeldt, Circ. Res. 118 (2016) 653-667. doi: 10.1161/CIRCRESAHA.115.306256
11. [11]
  G. Chinetti-Gbaguidi, S. Colin, B. Staels, Nat. Rev. Cardiol. 12 (2015) 10-17. doi: 10.1038/nrcardio.2014.173
12. [12]
  K.J. Moore, I. Tabas, Cell 145 (2011) 341-355. doi: 10.1016/j.cell.2011.04.005
13. [13]
  A. Laria, A. Lurati, M. Marrazza, et al., J. Inflammation Res. 9 (2016) 1-11.
14. [14]
  B. Kim, H.B. Pang, J. Kang, et al., Nat. Commun. 9 (2018) 1969. doi: 10.1038/s41467-018-04390-7
15. [15]
  Y. Song, Y. Huang, F. Zhou, J. Ding, W. Zhou, Chin. Chem. Lett. 33 (2022) 597-612. doi: 10.1016/j.cclet.2021.08.090
16. [16]
  K.J. Moore, F.J. Sheedy, E.A. Fisher, Nat. Rev. Immunol. 13 (2013) 709-721. doi: 10.1038/nri3520
17. [17]
  M. Bäck, A.Y. Jr, I. Tabas, K. Öörni, P.T. Kovanen, Nat. Rev. Cardiol. 16 (2019) 389-406.
18. [18]
  H.B. Cohen, D.M. Mosser, J. Leukocyte Biol. 94 (2013) 913-919. doi: 10.1189/jlb.0413236
19. [19]
  C. Yunna, H. Mengru, W. Lei, C. Weidong, Eur. J. Pharmacol. 877 (2020) 173090. doi: 10.1016/j.ejphar.2020.173090
20. [20]
  R. Rajakariar, M.M. Yaqoob, D.W. Gilroy, Mol. Interventions 6 (2006) 199. doi: 10.1124/mi.6.4.6
21. [21]
  L. Minghetti, J. Neuropathol. Exp. Neurol. 63 (2004) 901-910. doi: 10.1093/jnen/63.9.901
22. [22]
  H. Wang, S. Yang, H. Zhou, et al., J. Hematol. Oncol. 8 (2015) 1-13. doi: 10.1186/s13045-014-0099-8
23. [23]
  Y. Yang, S.J. Jin, H.L. Wang, et al., Scand. J. Pain 8 (2015) 28-34. doi: 10.1016/j.sjpain.2015.04.001
24. [24]
  P.U. Atukorale, G. Covarrubias, L. Bauer, E. Karathanasis, Adv. Drug Delivery Rev. 113 (2017) 141-156. doi: 10.1016/j.addr.2016.09.006
25. [25]
  J.W. Myerson, A.C. Anselmo, Y. Liu, et al., Adv. Drug Delivery Rev. 99 (2016) 97-112. doi: 10.1016/j.addr.2015.10.011
26. [26]
  M.D. Howard, E.D. Hood, B. Zern, et al., Annu. Rev. Pharmacol. Toxicol. 54 (2014) 205-226. doi: 10.1146/annurev-pharmtox-011613-140002
27. [27]
  A.M. Flores, J. Ye, K. Jarr, et al., Arterioscler. Thromb. Vasc. Biol. 39 (2019) 635-646. doi: 10.1161/atvbaha.118.311569
28. [28]
  F. Dormont, M. Varna, P. Couvreur, Mater. Today 21 (2018) 122-143. doi: 10.1016/j.mattod.2017.07.008
29. [29]
  D.R. Lewis, L.K. Petersen, A.W. York, et al., Proc. Natl. Acad. Sci. U. S. A. 112 (2015) 2693-2698. doi: 10.1073/pnas.1424594112
30. [30]
  S. Sha, L.B. Vong, P. Chonpathompikunlert, et al., Biomaterials 34 (2013) 8393-8400. doi: 10.1016/j.biomaterials.2013.06.032
31. [31]
  A. Eguchi, T. Yoshitomi, M. Lazic, et al., Nanomedicine 10 (2015) 2697-2708. doi: 10.2217/nnm.15.87
32. [32]
  C. Brenner, W.M. Franz, S. Kühlenthal, et al., Int. J. Cardiol. 199 (2015) 163-169. doi: 10.1016/j.ijcard.2015.07.044
33. [33]
  S. Yang, H.Q. Yuan, Y.M. Hao, et al., Clin. Chim. Acta 501 (2020) 142-146. doi: 10.1016/j.cca.2019.10.034
34. [34]
  H.Y. Tan, N. Wang, S. Li, et al., Oxid. Med. Cell. Longevity 2016 (2016) 2795090.
35. [35]
  Y. Yang, J. Wang, S. Guo, et al., Redox Biol. 32 (2020) 101501. doi: 10.1016/j.redox.2020.101501
36. [36]
  A. Chen, C. Ostrom, Chem. Rev. 115 (2015) 11999-12044. doi: 10.1021/acs.chemrev.5b00324
37. [37]
  M.A. Miller, B. Askevold, H. Mikula, et al., Nat. Commun. 8 (2017) 15906. doi: 10.1038/ncomms15906
38. [38]
  G. Fang, W. Li, X. Shen, et al., Nat. Commun. 9 (2018) 129. doi: 10.1038/s41467-017-02502-3
39. [39]
  J. Wu, X. Wang, Q. Wang, et al., Chem. Soc. Rev. 48 (2019) 1004-1076. doi: 10.1039/c8cs00457a
40. [40]
  C. Ge, G. Fang, X. Shen, et al., ACS Nano 10 (2016) 10436-10445. doi: 10.1021/acsnano.6b06297
41. [41]
  M. Jin, H. Zhang, Z. Xie, Y. Xia, Energy Environ. Sci. 5 (2012) 6352-6357. doi: 10.1039/C2EE02866B
42. [42]
  K. Yang, S. Zhang, G. Zhang, et al., Nano Lett. 10 (2010) 3318-3323. doi: 10.1021/nl100996u
43. [43]
  Z. Zhang, L. Wang, J. Wang, et al., Adv. Mater. 24 (2012) 1418-1423. doi: 10.1002/adma.201104714
44. [44]
  M.R. Bennett, S. Sinha, G.K. Owens, Circ. Res. 118 (2016) 692-702. doi: 10.1161/CIRCRESAHA.115.306361
1. [1]
  Feifei Wang , Hang Yao , Xinyue Wu , Yijian Tang , Yang Bai , Hui Chong , Huan Pang . Metal–organic framework and its composites modulate macrophage polarization in the treatment of inflammatory diseases. Chinese Chemical Letters, 2024, 35(5): 108821-. doi: 10.1016/j.cclet.2023.108821
2. [2]
  Xiaoyao Ma , Jinling Zhang , Ge Fang , He Gao , Jie Gao , Li Fu , Yuanyuan Hou , Gang Bai . Förster resonance energy transfer reveals phillygenin and swertiamarin concurrently target AKT on different binding domains to increase the anti-inflammatory effect. Chinese Chemical Letters, 2024, 35(5): 108823-. doi: 10.1016/j.cclet.2023.108823
3. [3]
  Lihang Wang , Mary Li Javier , Chunshan Luo , Tingsheng Lu , Shudan Yao , Bing Qiu , Yun Wang , Yunfeng Lin . Research advances of tetrahedral framework nucleic acid-based systems in biomedicine. Chinese Chemical Letters, 2024, 35(11): 109591-. doi: 10.1016/j.cclet.2024.109591
4. [4]
  Xiaoliu Liang , Chunliu Huang , Hui Liu , Hu Chen , Jiabao Shou , Hongwei Cheng , Gang Liu . Natural hydrogel dressings in wound care: Design, advances, and perspectives. Chinese Chemical Letters, 2024, 35(10): 109442-. doi: 10.1016/j.cclet.2023.109442
5. [5]
  Tao Yang , Kaijiao Duan , Siyu Li , Jing Wei , Qingdi Yang , Qian Wang . A Comprehensive and Innovative Chemical Experimental Teaching: Extraction and Identification of Tea Polyphenols from Pu'er Tea and the Application in Hand Cream Making. University Chemistry, 2024, 39(8): 270-275. doi: 10.3866/PKU.DXHX202312040
6. [6]
  Huijiao Fu , Peiqin Liang , Qianwen Chen , Yan Wang , Guang Li , Xuzi Cai , Shengtao Wang , Kun Chen , Shengying Shi , Zhiqiang Yu , Xuefeng Wang . COX-2 blocking therapy in cisplatin chemosensitization of ovarian cancer: An allicin-based nanomedicine approach. Chinese Chemical Letters, 2024, 35(8): 109241-. doi: 10.1016/j.cclet.2023.109241
7. [7]
  Chuyu Huang , Zhishan Liu , Linping Zhao , Zuxiao Chen , Rongrong Zheng , Xiaona Rao , Yuxuan Wei , Xin Chen , Shiying Li . Metal-coordinated oxidative stress amplifier to suppress tumor growth combined with M2 macrophage elimination. Chinese Chemical Letters, 2024, 35(12): 109696-. doi: 10.1016/j.cclet.2024.109696
8. [8]
  Zhenyu Hu , Zhenchun Yang , Shiqi Zeng , Kun Wang , Lina Li , Chun Hu , Yubao Zhao . Cationic surface polarization centers on ionic carbon nitride for efficient solar-driven H₂O₂ production and pollutant abatement. Chinese Chemical Letters, 2024, 35(10): 109526-. doi: 10.1016/j.cclet.2024.109526
9. [9]
  Zhenchun Yang , Bixiao Guo , Zhenyu Hu , Kun Wang , Jiahao Cui , Lina Li , Chun Hu , Yubao Zhao . Molecular engineering towards dual surface local polarization sites on poly(heptazine imide) framework for boosting H₂O₂ photo-production. Chinese Chemical Letters, 2024, 35(8): 109251-. doi: 10.1016/j.cclet.2023.109251
10. [10]
  Simin Wei , Yaqing Yang , Junjie Li , Jialin Wang , Jinlu Tang , Ningning Wang , Zhaohui Li . The Mn/Yb/Er triple-doped CeO₂ nanozyme with enhanced oxidase-like activity for highly sensitive ratiometric detection of nitrite. Chinese Chemical Letters, 2024, 35(6): 109114-. doi: 10.1016/j.cclet.2023.109114
11. [11]
  Botao Gao , He Qi , Hui Liu , Jun Chen . Role of polarization evolution in the hysteresis effect of Pb-based antiferroelecrtics. Chinese Chemical Letters, 2024, 35(4): 108598-. doi: 10.1016/j.cclet.2023.108598
12. [12]
  Mengli Xu , Zhenmin Xu , Zhenfeng Bian . Achieving Ullmann coupling reaction via photothermal synergy with ultrafine Pd nanoclusters supported on mesoporous TiO2. Chinese Journal of Structural Chemistry, 2024, 43(7): 100305-100305. doi: 10.1016/j.cjsc.2024.100305
13. [13]
  Jia Chen , Yun Liu , Zerong Long , Yan Li , Hongdeng Qiu . Colorimetric detection of α-glucosidase activity using Ni-CeO₂ nanorods and its application to potential natural inhibitor screening. Chinese Chemical Letters, 2024, 35(9): 109463-. doi: 10.1016/j.cclet.2023.109463
14. [14]
  Shuheng Zhang , Yuanyuan Zhang , Wanyu Wang , Yuzhu Hu , Xinchuan Chen , Bilan Wang , Xiang Gao . A combination strategy of DOX and VEGFR-2 targeted inhibitor based on nanomicelle for enhancing lymphoma therapy. Chinese Chemical Letters, 2024, 35(12): 109658-. doi: 10.1016/j.cclet.2024.109658
15. [15]
  Junhua Wang , Xin Lian , Xichuan Cao , Qiao Zhao , Baiyan Li , Xian-He Bu . Dual polarization strategy to enhance CH₄ uptake in covalent organic frameworks for coal-bed methane purification. Chinese Chemical Letters, 2024, 35(8): 109180-. doi: 10.1016/j.cclet.2023.109180
16. [16]
  Zhenghua ZHAO , Qin ZHANG , Yufeng LIU , Zifa SHI , Jinzhong GU . Syntheses, crystal structures, catalytic and anti-wear properties of nickel(Ⅱ) and zinc(Ⅱ) coordination polymers based on 5-(2-carboxyphenyl)nicotinic acid. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 621-628. doi: 10.11862/CJIC.20230342
17. [17]
  Xingyan Liu , Chaogang Jia , Guangmei Jiang , Chenghua Zhang , Mingzuo Chen , Xiaofei Zhao , Xiaocheng Zhang , Min Fu , Siqi Li , Jie Wu , Yiming Jia , Youzhou He . Single-atom Pd anchored in the porphyrin-center of ultrathin 2D-MOFs as the active center to enhance photocatalytic hydrogen-evolution and NO-removal. Chinese Chemical Letters, 2024, 35(9): 109455-. doi: 10.1016/j.cclet.2023.109455
18. [18]
  Yulong Shi , Fenbei Chen , Mengyuan Wu , Xin Zhang , Runze Meng , Kun Wang , Yan Wang , Yuheng Mei , Qionglu Duan , Yinghong Li , Rongmei Gao , Yuhuan Li , Hongbin Deng , Jiandong Jiang , Yanxiang Wang , Danqing Song . Chemical construction and anti-HCoV-OC43 evaluation of novel 10,12-disubstituted aloperine derivatives as dual cofactor inhibitors of TMPRSS2 and SR-B1. Chinese Chemical Letters, 2024, 35(5): 108792-. doi: 10.1016/j.cclet.2023.108792
19. [19]
  Xing Tian , Di Wu , Wanheng Wei , Guifu Dai , Zhanxian Li , Benhua Wang , Mingming Yu . A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death, inflammation and fatty liver tissue. Chinese Chemical Letters, 2024, 35(6): 108912-. doi: 10.1016/j.cclet.2023.108912
20. [20]
  Erzhuo Cheng , Yunyi Li , Wei Yuan , Wei Gong , Yanjun Cai , Yuan Gu , Yong Jiang , Yu Chen , Jingxi Zhang , Guangquan Mo , Bin Yang . Galvanostatic method assembled ZIFs nanostructure as novel nanozyme for the glucose oxidation and biosensing. Chinese Chemical Letters, 2024, 35(9): 109386-. doi: 10.1016/j.cclet.2023.109386

Get Citation

PDF

XML

Metrics

PDF Downloads(8)
Abstract views(778)
HTML views(57)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142