Citation: Yang Bai, Yujie Pan, Na An, Haitao Zhang, Chao Wang, Wei Tian, Tao Huang. Host-guest interactions based supramolecular complexes self-assemblies for amplified chemodynamic therapy with H₂O₂ elevation and GSH consumption properties[J]. Chinese Chemical Letters, ;2023, 34(1): 107552. doi: 10.1016/j.cclet.2022.05.066 shu

Host-guest interactions based supramolecular complexes self-assemblies for amplified chemodynamic therapy with H₂O₂ elevation and GSH consumption properties

Yang Bai ^{a, c, **,} ,
Yujie Pan ^a ,
Na An ^a ,
Haitao Zhang ^{b, *,} ,
Chao Wang ^a ,
Wei Tian ^{c, *,} ,
Tao Huang ^a

a.
Shaanxi Key Laboratory of Chemical Additives for Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China
b.
School of Light Industry Science and Engineering, Qilu University of Technology, Shandong Academy of Sciences, Ji'nan 250353, China
c.
MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an 710072, China

^**

baiyang@sust.edu.cn

zhanghaitao0218@hotmail.com

happytw_3000@nwpu.edu.cn

Received Date: 7 December 2021
Revised Date: 18 May 2022
Accepted Date: 20 May 2022
Available Online: 23 May 2022

Figures(7)

Although endogenous H₂O₂ is overexpressed in tumor tissue, the amount of endogenous H₂O₂ is still insufficient for chemodynamic therapy (CDT). In addition, the abundant cellular glutathione (GSH) could also consume ^•OH for reduced CDT. Thus, the elevation of H₂O₂ and the consumption of GSH in tumor tissue are essential for the increased ^•OH yield and amplified CDT efficacy. In this paper, host-guest interactions based supramolecular complexes self-assemblies (SCSAs) were fabricated by incorporating cinnamaldehyde (CA) and PEG-modified cyclodextrin host units (mPEG-CD-CA) with ferrocene-(phenylboronic acid pinacol ester) conjugates (Fc-BE) on the basis of CD-induced host-guest interactions. After being internalized by cancer cells, CA can be released from SCSAs through the pH-responsive acetal linkage, elevating the H₂O₂ level by activating NADPH oxidase. Then, Fc can catalyze the H₂O₂ to higher cytotoxic hydroxyl radicals (^•OH). Moreover, quinone methide (QM) can be produced through H₂O₂-induced aryl boronic ester rearrangement and further consume the antioxidant GSH. In vitro and in vivo experiments demonstrate that SCSAs can be provided as potential amplified CDT nanoagents.
- Cyclodextrin,
- Host-guest inclusion interactions,
- Chemodynamic therapy
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Host-guest interactions based supramolecular complexes self-assemblies for amplified chemodynamic therapy with H2O2 elevation and GSH consumption properties

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通讯作者: 陈斌, bchen63@163.com

Host-guest interactions based supramolecular complexes self-assemblies for amplified chemodynamic therapy with H₂O₂ elevation and GSH consumption properties