Citation: Zexian Li, Jianfeng Zheng, Wei-Dong Z. Li. Diverse strategic approaches en route to Taxol total synthesis[J]. Chinese Chemical Letters, ;2022, 33(12): 4957-4968. doi: 10.1016/j.cclet.2022.04.029 shu

Diverse strategic approaches en route to Taxol total synthesis

Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China

jfzheng@swjtu.edu.cn

wdli@swjtu.edu.cn

Received Date: 15 February 2022
Revised Date: 11 April 2022
Accepted Date: 12 April 2022
Available Online: 15 April 2022

Figures(38)

Taxol is one of the most famous diterpenoid natural products used in clinical cancer therapy. Taxol and its analogues are popular synthetic targets and have attracted worldwide attention over the past decades. Tremendous research efforts have already been made and ten groups have achieved the total synthesis of Taxol since 1994. This mini-review summarized the recent highlights of divergent strategic approaches towards the chemical synthesis of Taxol's carbocyclic framework bearing a bridged eight-membered ring.
- Taxol,
- Total synthesis,
- Biomimetic synthesis,
- Linear strategy,
- Convergent strategy
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沈阳化工大学材料科学与工程学院沈阳 110142