Citation: Yunxia Wang, Chuangxin Zhang, Hui Zhang, Liheng Feng, Libing Liu. A hybrid nano-assembly with synergistically promoting photothermal and catalytic radical activity for antibacterial therapy[J]. Chinese Chemical Letters, ;2022, 33(10): 4605-4609. doi: 10.1016/j.cclet.2022.03.076 shu

A hybrid nano-assembly with synergistically promoting photothermal and catalytic radical activity for antibacterial therapy

Yunxia Wang ^a ,
Chuangxin Zhang ^a ,
Hui Zhang ^a ,
Liheng Feng ^{a, *,} ,
Libing Liu ^{b, c, *,}

a.
School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
b.
Department of Nutrition and Health, China Agricultural University, Beijing 100193, China
c.
Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

lhfeng@sxu.edu.cn

liulibing@iccas.ac.cn

Received Date: 2 December 2021
Revised Date: 10 March 2022
Accepted Date: 16 March 2022
Available Online: 19 March 2022

Figures(5)

It is of great significance to develop effective antibacterial agents and methods to combat drug resistant bacterial infections due to its increasing threaten to human health and the ineffectiveness of antibiotics. Herein, a multifunctional hybrid nano-assembly (M1-Fe NPs) based on conjugated oligomer and ferrous ion was engineered with favorable bactericidal activity for synergetic antibacterial therapy. The chelation of ferrous ion not only enhances the photothermal conversion efficiency of M1 but also endows the nano-assembly with catalytic capability of transferring H₂O₂ into stronger oxidant hydroxyl radicals (^•OH). Meanwhile, the generated heat can further promote the Fenton reaction activity. By generating cytotoxic heat and oxidative ^•OH, M1-Fe NPs can effectively kill Staphylococcus aureus in vitro and in vivo with the aid of low dosage of H₂O₂. The work provides a new multifunctional platform for combinational drug resistant antibacterial therapy and even antitumor therapy.
- Conjugated oligomer,
- Nano-assembly,
- Fenton reaction,
- Photothermal therapy,
- Bacterial infections
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