Citation: Yu Chong, Jiayu Ning, Shengyi Min, Jiaquan Ye, Cuicui Ge. Emerging nanozymes for potentiating radiotherapy and radiation protection[J]. Chinese Chemical Letters, ;2022, 33(7): 3315-3324. doi: 10.1016/j.cclet.2022.03.054 shu

Emerging nanozymes for potentiating radiotherapy and radiation protection

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China

chongyu@suda.edu.cn

ccge@suda.edu.cn

Received Date: 16 January 2022
Revised Date: 10 March 2022
Accepted Date: 14 March 2022
Available Online: 16 March 2022

Figures(16)

While radiotherapy is a mainstay therapeutic modality for malignant tumor, the intrinsic tumor resistance to radiotherapy, as well as the concomitant radiation injury to adjacent healthy tissues, greatly limits the efficacy of cancer radiotherapy. As a result, the development of novel radioenhancers and radioprotectants is highly desired for clinical radiotherapy. In recent years, nanozymes have inspired ever-growing research interest because of their multi-enzyme activities and microenvironment-responsive feature. In view of the significant progress of nanozymes in radiation medicine, we, in this review, systematically illustrate the impressive progress of nanozymes for potentiating radiotherapy and radiation protection. First, the types of nanozymes used in tumor radiotherapy are briefly discussed. Subsequently, the main strategies of nanozymes to enhance the radiotherapy efficiency, including promoting the generation of reactive oxygen species (ROS), relieving hypoxia in tumor microenvironment and combining with other cancer therapeutic regimens, are summarized. Finally, the advances of typical nanozymes for preventing radiation-induced hematopoietic damage and gastrointestinal damage are highlighted.
- Nanozyme,
- Radiation therapy,
- Radiosensitization,
- ROS,
- Hypoxia
1. [1]
  M. Gospodarowicz, J.C.O. Glob. Oncol. 7 (2021) 144–145. doi: 10.1200/go.20.00562
2. [2]
  A.J. Wisdom, C.S. Hong, A.J. Lin, et al., Proc. Natl. Acad. Sci. U. S. A. 116 (2019) 18584–18589. doi: 10.1073/pnas.1901562116
3. [3]
  Y.M. Zhang, F. Huang, C.H. Ren, et al., Adv. Sci. 6 (2019) 1801806. doi: 10.1002/advs.201801806
4. [4]
  Y.L. Wei, J.Y. Xu, R. Zhang, et al., Appl. Radiat. Isot. 146 (2019) 72–77. doi: 10.1016/j.apradiso.2019.01.014
5. [5]
  B. Wang, J.L. Dong, H.W. Xiao, et al., Sci. Total Environ. 732 (2020) 139274. doi: 10.1016/j.scitotenv.2020.139274
6. [6]
  A.M. Buckley, N. Lynam-Lennon, H. O'Neill, J. O'Sullivan, Nat. Rev. Gastroenterol. Hepatol. 17 (2020) 298–313. doi: 10.1038/s41575-019-0247-2
7. [7]
  M. King, S. Joseph, A. Albert, et al., Oncology 98 (2020) 61–80. doi: 10.1159/000502979
8. [8]
  S. Bonvalot, P.L. Rutkowski, J. Thariat, Lancet Oncol. 20 (2019) 468-468.
9. [9]
  R.Y. Zhao, H.L. Liu, Y.M. Li, M.L. Guo, X.D. Zhang, Bioconjugate Chem. 32 (2021) 411–429. doi: 10.1021/acs.bioconjchem.0c00648
10. [10]
  Y. Chong, J. Huang, X.Y. Xu, et al., Bioconjugate Chem. 31 (2020) 1756–1765. doi: 10.1021/acs.bioconjchem.0c00224
11. [11]
  Y.Y. Chen, H. Zhong, J.B. Wang, et al., Chem. Sci. 11 (2020) 6098. doi: 10.1039/d0sc90108c
12. [12]
  F. Liu, L. Lin, Y. Zhang, et al., Adv. Mater. 31 (2019) 1902885. doi: 10.1002/adma.201902885
13. [13]
  J.J.X. Wu, X.Y. Wang, Q. Wang, et al., Chem. Soc. Rev. 48 (2019) 1004–1076. doi: 10.1039/c8cs00457a
14. [14]
  D.W. Jiang, D.L. Ni, Z.T. Rosenkrans, et al., Chem. Soc. Rev. 48 (2019) 3683–3704. doi: 10.1039/c8cs00718g
15. [15]
  Y.Y. Huang, J.S. Ren, X.G. Qu, Chem. Rev. 119 (2019) 4357–4412. doi: 10.1021/acs.chemrev.8b00672
16. [16]
  L.Z. Gao, J. Zhuang, L. Nie, et al., Nat. Nanotechnol. 2 (2007) 577–583. doi: 10.1038/nnano.2007.260
17. [17]
  Z.R. Wang, R.F. Zhang, X.Y. Yan, K.L. Fan, Mater. Today41 (2020) 81–119. doi: 10.1016/j.mattod.2020.08.020
18. [18]
  R.F. Wu, Y. Chong, G. Fang, et al., Adv. Funct. Mater. 28 (2018) 1801484. doi: 10.1002/adfm.201801484
19. [19]
  N. Singh, M.A. Savanur, S. Srivastava, P. D'Silva, G. Mugesh, Angew. Chem. Int. Edit. 56 (2017) 14267–14271. doi: 10.1002/anie.201708573
20. [20]
  Y.X. Zhang, P. Murugesan, K. Huang, H. Cai, Nat. Rev. Cardiol. 17 (2020) 170–194. doi: 10.1038/s41569-019-0260-8
21. [21]
  Y. Chong, Q. Liu, C.C. Ge, Nano Today37 (2021) 101076. doi: 10.1016/j.nantod.2021.101076
22. [22]
  S.S. Gao, H. Lin, H.X. Zhang, et al., Adv. Sci. 6 (2019) 1801733. doi: 10.1002/advs.201801733
23. [23]
  Y. Chong, X. Dai, G. Fang, et al., Nat. Commun. 9 (2018) 4861. doi: 10.1038/s41467-018-07257-z
24. [24]
  H.S. Tehrani, A.A. Moosavi-Movahedi, Prog. Biophys. Mol. Bio. 140 (2018) 5–12. doi: 10.1016/j.pbiomolbio.2018.03.001
25. [25]
  S.Y. Li, W.J. Sun, Y. Luo, et al., J. Mater. Chem. B9 (2021) 4643–4653. doi: 10.1039/d1tb00486g
26. [26]
  W. Pan, B.J. Cui, P. Gao, et al., Chem. Commun. 56 (2020) 547–550. doi: 10.1039/c9cc07878a
27. [27]
  Y. Liu, H.H. Wu, M. Li, J.J. Yin, Z.H. Nie, Nanoscale 6 (2014) 11904–11910. doi: 10.1039/C4NR03848G
28. [28]
  Z.M. He, X.L. Huang, C. Wang, et al., Angew. Chem. Int. Edit. 58 (2019) 8752–8756. doi: 10.1002/anie.201902612
29. [29]
  J.Y. Wang, X.Y. Mu, Y.H. Li, et al., Small14 (2018) 1703736. doi: 10.1002/smll.201703736
30. [30]
  C.Q. Zhong, X.J. Huang, S. Zhang, et al., Braz. J. Pharm. Sci. 53 (2017) 17081.
31. [31]
  H.W. Kroto, J.R. Heath, S.C. O'Brien, R.F. Curl, R.E. Smalley, Nature 318 (1985) 162–163. doi: 10.1038/318162a0
32. [32]
  A.S. Karakoti, S. Singh, A. Kumar, et al., J. Am. Chem. Soc. 131 (2009) 14144–14145. doi: 10.1021/ja9051087
33. [33]
  C.C. Ge, G. Fang, X.M. Shen, et al., ACS Nano10 (2016) 10436–10445. doi: 10.1021/acsnano.6b06297
34. [34]
  Y. Liu, H.H. Wu, Y. Chong, et al., ACS Appl. Mater. Interfaces7 (2015) 19709–19717. doi: 10.1021/acsami.5b05180
35. [35]
  Y. Chong, C.C. Ge, G. Fang, et al., ACS Nano10 (2016) 8690–8699. doi: 10.1021/acsnano.6b04061
36. [36]
  S. Goel, D.L. Ni, W.B. Cai, ACS Nano11 (2017) 5233–5237. doi: 10.1021/acsnano.7b03675
37. [37]
  X.F. Chen, J.B. Song, X.Y. Chen, H.H. Yang, Chem. Soc. Rev. 48 (2019) 3073–3101. doi: 10.1039/c8cs00921j
38. [38]
  J.N. Xie, L.J. Gong, S. Zhu, et al., Adv. Mater. 31 (2019) 1802244. doi: 10.1002/adma.201802244
39. [39]
  G.S. Song, L. Cheng, Y. Chao, K. Yang, Z. Liu, Adv. Mater. 29 (2017) 1700996. doi: 10.1002/adma.201700996
40. [40]
  Z. Wang, S.W. Liu, L. Wang, et al., ACS Appl. Bio Mater. 3 (2020) 5080–5092. doi: 10.1021/acsabm.0c00573
41. [41]
  J.S. Lu, Z.H. Guo, W.S. Xie, et al., Biomater. Sci. 9 (2021) 3979–3988. doi: 10.1039/d1bm00306b
42. [42]
  Z.L. Dong, L.Z. Feng, Y. Chao, et al., Nano Lett. 19 (2019) 805–815. doi: 10.1021/acs.nanolett.8b03905
43. [43]
  Q. Liu, Y. Shi, Y. Chong, C.C. Ge, ACS Appl. Bio Mater. 4 (2021) 1843–1851. doi: 10.1021/acsabm.0c01537
44. [44]
  R.Y. Zhou, H.M. Wang, Y.F. Yang, et al., Biomaterials 189 (2019) 11–22. doi: 10.1016/j.biomaterials.2018.10.016
45. [45]
  R. Cheng, H.M. Liu, X.H. Dong, et al., Chem. Eng. J. 394 (2020) 124872. doi: 10.1016/j.cej.2020.124872
46. [46]
  X. Wang, C.Y. Zhang, J.F. Du, et al., ACS Nano13 (2019) 5947–5958. doi: 10.1021/acsnano.9b01818
47. [47]
  C.Y. Zhang, L. Yan, X.H. Wang, et al., Nano Lett. 19 (2019) 1749–1757. doi: 10.1021/acs.nanolett.8b04763
48. [48]
  C.Y. Zhang, X. Wang, X. Dong, et al., Biomaterials 276 (2021) 121023. doi: 10.1016/j.biomaterials.2021.121023
49. [49]
  P. Prasad, C.R. Gordijo, A.Z. Abbasi, et al., ACS Nano8 (2014) 3202–3212. doi: 10.1021/nn405773r
50. [50]
  L.L. Tian, Q. Chen, X. Yi, et al., Small13 (2017) 1700640. doi: 10.1002/smll.201700640
51. [51]
  J.W. Chen, Q. Chen, C. Liang, et al., Nanoscale 9 (2017) 14826–14835. doi: 10.1039/C7NR05316A
52. [52]
  F. Gong, J.W. Chen, X. Han, et al., J. Mater. Chem. B6 (2018) 2250–2257. doi: 10.1039/c8tb00070k
53. [53]
  R.F. Zhang, L. Chen, Q. Liang, et al., Nano Today41 (2021) 101317. doi: 10.1016/j.nantod.2021.101317
54. [54]
  R.Z. Hu, Z.X. Chen, C. Dai, et al., Biomaterials 269 (2021) 120455. doi: 10.1016/j.biomaterials.2020.120455
55. [55]
  L.Z. Feng, Z.L. Dong, C. Liang, et al., Biomaterials 181 (2018) 81–91. doi: 10.1016/j.biomaterials.2018.07.049
56. [56]
  Y.Z. Yao, P.Z. Li, J.K. He, et al., ACS Appl. Mater. Interfaces13 (2021) 28650–28661. doi: 10.1021/acsami.1c05669
57. [57]
  S.X. Lv, W. Long, J.C. Chen, et al., Nanoscale 12 (2020) 548–557. doi: 10.1039/c9nr08192e
58. [58]
  Y. Yang, M. Chen, B.Z. Wang, et al., Angew. Chem. Int. Edit. 58 (2019) 15069–15075. doi: 10.1002/anie.201906758
59. [59]
  K.Y. Ni, G.X. Lan, Y. Song, Z.Y. Hao, W.B. Lin, Chem. Sci. 11 (2020) 7641–7653. doi: 10.1039/d0sc01949f
60. [60]
  W.P. Fan, W.B. Bu, B. Shen, et al., Adv. Mater. 27 (2015) 4155–4161. doi: 10.1002/adma.201405141
61. [61]
  D.M. Zhu, M. Lyu, W. Jiang, et al., J. Mater. Chem. B8 (2020) 5312–5319. doi: 10.1039/d0tb00676a
62. [62]
  L.T. Meng, Y.L. Cheng, S.J. Gan, et al., Mol. Pharm. 15 (2018) 447–457. doi: 10.1021/acs.molpharmaceut.7b00808
63. [63]
  X.T. Zhou, M. You, F.H. Wang, et al., Adv. Mater. 33 (2021) 2100556. doi: 10.1002/adma.202100556
64. [64]
  S.C. Jia, S.F. Ge, X.Q. Fan, K.W. Leong, J. Ruan, Nanomedicine16 (2021) 759–778. doi: 10.2217/nnm-2020-0448
65. [65]
  S. Rey, L. Schito, M. Koritzinsky, B.G. Wouters, Adv. Drug Deliv. Rev. 109 (2017) 45–62. doi: 10.1016/j.addr.2016.10.002
66. [66]
  H.E. Barker, J.T.E. Paget, A.A. Khan, K.J. Harrington, Nat. Rev. Cancer15 (2015) 409–425. doi: 10.1038/nrc3958
67. [67]
  C. Zhang, L. Yan, Z.J. Gu, Y.L. Zhao, Chem. Sci. 10 (2019) 6932–6943. doi: 10.1039/c9sc02107h
68. [68]
  A. Sahu, I. Kwon, G. Tae, Biomaterials 228 (2020) 119578. doi: 10.1016/j.biomaterials.2019.119578
69. [69]
  H.M. Liu, R. Cheng, X.H. Dong, et al., Inorg. Chem. 59 (2020) 3482–3493. doi: 10.1021/acs.inorgchem.9b03280
70. [70]
  C.R. Gordijo, A.Z. Abbasi, M.A. Amini, et al., Adv. Funct. Mater. 25 (2015) 1858–1872. doi: 10.1002/adfm.201404511
71. [71]
  A.Z. Abbasi, C.R. Gordijo, M.A. Amini, et al., Cancer Res. 76 (2016) 6643–6656. doi: 10.1158/0008-5472.CAN-15-3475
72. [72]
  M.H. Cho, E.S. Choi, S. Kim, et al., Front. Chem. 5 (2017) 109. doi: 10.3389/fchem.2017.00109
73. [73]
  Y.D. Wang, S.Z. Song, T. Lu, et al., Biomaterials 220 (2019) 119405. doi: 10.1016/j.biomaterials.2019.119405
74. [74]
  Y. Li, K.H. Yun, H. Lee, et al., Biomaterials 197 (2019) 12–19. doi: 10.1016/j.biomaterials.2019.01.004
75. [75]
  H.J. Wang, D.L. Jia, D.D. Yuan, et al., J. Nanobiotechnology19 (2021) 138. doi: 10.1186/s12951-021-00885-6
76. [76]
  E.H. Donnelly, J.B. Nemhauser, J.M. Smith, et al., South. Med. J. 103 (2010) 541–546. doi: 10.1097/SMJ.0b013e3181ddd571
77. [77]
  V.K. Singh, T.M. Seed, Expert Opin. Drug Saf. 18 (2019) 1077–1090. doi: 10.1080/14740338.2019.1666104
78. [78]
  A.L. Popov, S.I. Zaichkina, N.R. Popova, et al., RSC Adv. 6 (2016) 106141–106149. doi: 10.1039/C6RA18566E
79. [79]
  X.D. Zhang, J.X. Zhang, J.Y. Wang, et al., ACS Nano10 (2016) 4511–4519. doi: 10.1021/acsnano.6b00321
80. [80]
  V. Jacevic, D. Jovic, K. Kuca, et al., J. Appl. Biomed. 14 (2016) 285–297. doi: 10.1016/j.jab.2016.05.004
81. [81]
  F.J. Xu, X.Y. Mu, J.Y. Wang, et al., J. Biomed. Nanotechnol. 13 (2017) 1512–1521. doi: 10.1166/jbn.2017.2468
82. [82]
  W. Long, J.Y. Wang, F.J. Xu, et al., Chin. Chem. Lett. 31 (2020) 269–274. doi: 10.1016/j.cclet.2019.03.044
83. [83]
  H. Li, Z.Y. Yang, C. Liu, et al., Free Radic. Biol. Med. 87 (2015) 26–35. doi: 10.1016/j.freeradbiomed.2015.06.010
84. [84]
  J.N. Xie, N. Wang, X.H. Dong, et al., ACS Appl. Mater. Interfaces11 (2019) 2579–2590. doi: 10.1021/acsami.8b00949
85. [85]
  J.Y. Wang, X.J. Cui, H.B. Li, et al., Nano Res. 11 (2018) 2821–2835. doi: 10.1007/s12274-017-1912-9
86. [86]
  X.D. Zhang, Y.Q. Jing, S.S. Song, Nanomedicine13 (2017) 1597–1605. doi: 10.1016/j.nano.2017.02.018
87. [87]
  X.Y. Ren, M.F. Huo, M.M. Wang, ACS Nano13 (2019) 6438–6454. doi: 10.1021/acsnano.8b09327
88. [88]
  W. Long, X.Y. Mu, J.Y. Wang, Front. Chem. 7 (2019) 784. doi: 10.3389/fchem.2019.00784
89. [89]
  J. Colon, N. Hsieh, A. Ferguson, Nanomedicine6 (2010) 698–705. doi: 10.1016/j.nano.2010.01.010
90. [90]
  S.I. Han, S.W. Lee, M.G. Cho, Adv. Mater. 32 (2020) 2001566. doi: 10.1002/adma.202001566
91. [91]
  C.Y. Wang, J.N. Xie, X.H. Dong, Small16 (2020) 1906915. doi: 10.1002/smll.201906915
92. [92]
  J.N. Xie, C.Y. Wang, N. Wang, Biomaterials 244 (2020) 119940. doi: 10.1016/j.biomaterials.2020.119940
93. [93]
  X.H. Li, W.C. Cui, L. Hull, et al., Radiat. Res. 190 (2018) 612–622. doi: 10.1667/rr15087.1
94. [94]
  S. Sun, H.L. Liu, Q. Xin, et al., Nano Lett. 21 (2021) 2562–2571. doi: 10.1021/acs.nanolett.0c05148
95. [95]
  A.A. Vernekar, D. Sinha, S. Srivastava, et al., Nat. Commun. 5 (2014) 5301. doi: 10.1038/ncomms6301
96. [96]
  N.R. Popova, A.L. Popov, A.M. Ermakov, V.V. Reukov, V.K. Ivanov, Molecules25 (2020) 2957. doi: 10.3390/molecules25132957
97. [97]
  A. Salvetti, G. Gambino, L. Rossi, et al., Mat. Sci. Eng. C-Mater. 115 (2020) 111113. doi: 10.1016/j.msec.2020.111113
98. [98]
  X.T. Bai, J.Y. Wang, X.Y. Mu, et al., ACS Biomater. Sci. Eng. 3 (2017) 460–470. doi: 10.1021/acsbiomaterials.6b00714
99. [99]
  W.L. Huang, J.S. Yu, J.W. Jones, et al. Health Phys. 116 (2019) 516–528. doi: 10.1097/hp.0000000000000951
100. [100]
  M. Soh, D.W. Kang, H.G. Jeong, Angew. Chem. Int. Edit. 56 (2017) 11399–11403. doi: 10.1002/anie.201704904
101. [101]
  J.N. Xie, M.R. Zhao, C.Y. Wang, et al., Chem. Eng. J. 430 (2022) 132866. doi: 10.1016/j.cej.2021.132866
1. [1]
  Xiaoshuai Wu , Bailei Wang , Yichen Li , Xiaoxuan Guan , Mingjing Yin , Wenquan Lv , Yin Chen , Fei Lu , Tao Qin , Huyang Gao , Weiqian Jin , Yifu Huang , Cuiping Li , Ming Gao , Junyu Lu . NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS. Chinese Chemical Letters, 2025, 36(2): 110211-. doi: 10.1016/j.cclet.2024.110211
2. [2]
  Caixia Zhu , Qing Hong , Kaiyuan Wang , Yanfei Shen , Songqin Liu , Yuanjian Zhang . Single nanozyme-based colorimetric biosensor for dopamine with enhanced selectivity via reactivity of oxidation intermediates. Chinese Chemical Letters, 2024, 35(10): 109560-. doi: 10.1016/j.cclet.2024.109560
3. [3]
  Ke Gong , Jinghan Liao , Jiangtao Lin , Quan Wang , Zhihua Wu , Liting Wang , Jiali Zhang , Yi Dong , Yourong Duan , Jianhua Chen . Mitochondria-targeted nanoparticles overcome chemoresistance via downregulating BACH1/CD47 axis in ovarian carcinoma. Chinese Chemical Letters, 2024, 35(5): 108888-. doi: 10.1016/j.cclet.2023.108888
4. [4]
  Maosen Xu , Pengfei Zhu , Qinghong Cai , Meichun Bu , Chenghua Zhang , Hong Wu , Youzhou He , Min Fu , Siqi Li , Xingyan Liu . In-situ fabrication of TiO₂/NH₂−MIL-125(Ti) via MOF-driven strategy to promote efficient interfacial effects for enhancing photocatalytic NO removal activity. Chinese Chemical Letters, 2024, 35(10): 109524-. doi: 10.1016/j.cclet.2024.109524
5. [5]
  Jia Chen , Yun Liu , Zerong Long , Yan Li , Hongdeng Qiu . Colorimetric detection of α-glucosidase activity using Ni-CeO₂ nanorods and its application to potential natural inhibitor screening. Chinese Chemical Letters, 2024, 35(9): 109463-. doi: 10.1016/j.cclet.2023.109463
6. [6]
  Manoj Kumar Sarangi , L․D Patel , Goutam Rath , Sitansu Sekhar Nanda , Dong Kee Yi . Metal organic framework modulated nanozymes tailored with their biomedical approaches. Chinese Chemical Letters, 2024, 35(11): 109381-. doi: 10.1016/j.cclet.2023.109381
7. [7]
  Chao Zhang , Ai-Feng Liu , Shihui Li , Fang-Yuan Chen , Jun-Tao Zhang , Fang-Xing Zeng , Hui-Chuan Feng , Ping Wang , Wen-Chao Geng , Chuan-Rui Ma , Dong-Sheng Guo . A supramolecular formulation of icariin@sulfonatoazocalixarene for hypoxia-targeted osteoarthritis therapy. Chinese Chemical Letters, 2025, 36(1): 109752-. doi: 10.1016/j.cclet.2024.109752
8. [8]
  Ling-Ling Wu , Xiangchuan Meng , Qingyang Zhang , Xiaowan Han , Feiya Yang , Qinghua Wang , Hai-Yu Hu , Nianzeng Xing . Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108663-. doi: 10.1016/j.cclet.2023.108663
9. [9]
  Liangliang Jia , Ye Hong , Xinyu He , Ying Zhou , Liujiao Ren , Hongjun Du , Bin Zhao , Bin Qin , Zhe Yang , Di Gao . Fighting hypoxia to improve photodynamic therapy-driven immunotherapy: Alleviating, exploiting and disregarding. Chinese Chemical Letters, 2025, 36(2): 109957-. doi: 10.1016/j.cclet.2024.109957
10. [10]
  Ji Liu , Dongsheng He , Tianjiao Hao , Yumin Hu , Yan Zhao , Zhen Li , Chang Liu , Daquan Chen , Qiyue Wang , Xiaofei Xin , Yan Shen . Gold mineralized "hybrid nanozyme bomb" for NIR-II triggered tumor effective permeation and cocktail therapy. Chinese Chemical Letters, 2024, 35(9): 109296-. doi: 10.1016/j.cclet.2023.109296
11. [11]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
12. [12]
  Erzhuo Cheng , Yunyi Li , Wei Yuan , Wei Gong , Yanjun Cai , Yuan Gu , Yong Jiang , Yu Chen , Jingxi Zhang , Guangquan Mo , Bin Yang . Galvanostatic method assembled ZIFs nanostructure as novel nanozyme for the glucose oxidation and biosensing. Chinese Chemical Letters, 2024, 35(9): 109386-. doi: 10.1016/j.cclet.2023.109386
13. [13]
  Yuanyuan Zeng , Fang Liu , Jun Wang , Bianfei Shao , Tao He , Zhongzheng Xiang , Yan Wang , Shunyao Zhu , Tian Yang , Siting Yu , Changyang Gong , Lei Liu . Fisetin micelles precisely exhibit a radiosensitization effect by inhibiting PDGFRβ/STAT1/STAT3/Bcl-2 signaling pathway in tumor. Chinese Chemical Letters, 2025, 36(2): 109734-. doi: 10.1016/j.cclet.2024.109734
14. [14]
  Cheng-Zhe Gao , Hao-Ran Jia , Tian-Yu Wang , Xiao-Yu Zhu , Xiaofeng Han , Fu-Gen Wu . A dual drug-loaded tumor vasculature-targeting liposome for tumor vasculature disruption and hypoxia-enhanced chemotherapy. Chinese Chemical Letters, 2025, 36(1): 109840-. doi: 10.1016/j.cclet.2024.109840
15. [15]
  Ruixin Liu , Feng Shi , Yanping Xia , Haibing Zhu , Jiawen Cao , Kai Peng , Chuanli Ren , Juan Li , Zhanjun Yang . Universal MOF nanozyme-induced catalytic amplification strategy for label-free electrochemical immunoassay. Chinese Chemical Letters, 2024, 35(11): 109664-. doi: 10.1016/j.cclet.2024.109664
16. [16]
  Simin Wei , Yaqing Yang , Junjie Li , Jialin Wang , Jinlu Tang , Ningning Wang , Zhaohui Li . The Mn/Yb/Er triple-doped CeO₂ nanozyme with enhanced oxidase-like activity for highly sensitive ratiometric detection of nitrite. Chinese Chemical Letters, 2024, 35(6): 109114-. doi: 10.1016/j.cclet.2023.109114
17. [17]
  Han Han , Bi-Te Chen , Jia-Rong Ding , Jin-Ming Si , Tian-Jiao Zhou , Yi Wang , Lei Xing , Hu-Lin Jiang . A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy. Chinese Chemical Letters, 2024, 35(10): 109583-. doi: 10.1016/j.cclet.2024.109583
18. [18]
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19. [19]
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沈阳化工大学材料科学与工程学院沈阳 110142