Citation: Yanjun Yang, Yifeng Zhang, Ran Wang, Xiang Rong, Ting Liu, Xiang Xia, Jiangli Fan, Wen Sun, Xiaojun Peng. A glutathione activatable pro-drug-photosensitizer for combined chemotherapy and photodynamic therapy[J]. Chinese Chemical Letters, ;2022, 33(10): 4583-4586. doi: 10.1016/j.cclet.2022.03.040 shu

A glutathione activatable pro-drug-photosensitizer for combined chemotherapy and photodynamic therapy

Yanjun Yang ^a ,
Yifeng Zhang ^a ,
Ran Wang ^a ,
Xiang Rong ^a ,
Ting Liu ^a ,
Xiang Xia ^a ,
Jiangli Fan ^{a, b} ,
Wen Sun ^{a, b, *,} ,
Xiaojun Peng ^a

a.
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China
b.
Ningbo Institute of Dalian University of Technology, Ningbo 315016, China

sunwen@dlut.edu.cn

Received Date: 27 December 2021
Revised Date: 4 March 2022
Accepted Date: 9 March 2022
Available Online: 13 March 2022

Figures(5)

During cancer treatment, chemotherapeutic drugs always result in severe side-effects and drug resistance. Therefore, combining cheomtherapy with other therapeutic modalities, such as photodynamic therapy (PDT) and designing an activable platform is promising for precise and efficient anticancer treatment. Herein, we report a "pro-drug-photosensitizer" agent, LMB-S-CPT, bearing a disulfide bond as the glutathione (GSH)-activatable linker. LMB-S-CPT can be selectively activated by GSH to release activated drug, camptothecin (CPT), for chemotherapy and activated photosensitizer, methylene blue (MB), for PDT. LMB-S-CPT exhibits excellent tumor-activatable performance when injected into tumor-bearing mice, as well as specific cancer therapy with negligible toxic side effects. The activatable pro-drug-photosensitizer offers a new strategy for chemo-photodynamic therapy and displays precise, selective and excellent antitumor effect.
- Pro-drug-photosensitizer,
- Chemotherapy,
- Photodynamic therapy,
- GSH activation
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