Citation: Xueqian Chen, Wenchao Niu, Zhongying Du, Yong Zhang, Dongdong Su, Xueyun Gao. ⁶⁴Cu radiolabeled nanomaterials for positron emission tomography (PET) imaging[J]. Chinese Chemical Letters, ;2022, 33(7): 3349-3360. doi: 10.1016/j.cclet.2022.02.070 shu

⁶⁴Cu radiolabeled nanomaterials for positron emission tomography (PET) imaging

Department of Chemistry and Biology, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China

chmsudd@bjut.edu.cn

gaoxy@ihep.ac.cn

Received Date: 1 December 2021
Revised Date: 25 February 2022
Accepted Date: 25 February 2022
Available Online: 1 March 2022

Figures(8)

The prevalence of positron emission tomography (PET) imaging has advanced biomedical applications for its ultrahigh sensitivity, deep tissue penetration and quantitative visualization of diseases in vivo. ⁶⁴Cu with ideal half-life and decay characteristics has been designed as radioactive probes for disease diagnosis. The currently reported ⁶⁴Cu-labeled nanomaterials have the advantages of long circulation time in serum, good biocompatibility and mature preparation methods, and have been used in vivo PET imaging, biodistribution and pharmacokinetic monitoring, and imaging guided therapy. At the same time, suitable carrier characteristics and radiolabeling strategies are particularly important in the ⁶⁴Cu PET imaging process. In this review, we summarize different imaging probe designs and ⁶⁴Cu radiolabeling strategies, as well as their eventual applications in biomedicine. The potential challenges and prospects of ⁶⁴Cu labeled nanomaterials are also described, which provides broad prospects for radiolabeling strategies and further applications.
- ⁶⁴Cu,
- Positron emission tomography,
- Chelating agent-free,
- Radiolabeling strategies,
- Imaging guided therapy
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沈阳化工大学材料科学与工程学院沈阳 110142

64Cu radiolabeled nanomaterials for positron emission tomography (PET) imaging

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⁶⁴Cu radiolabeled nanomaterials for positron emission tomography (PET) imaging