Citation: Ya-Qiong Yan, Hao Wang, Yuliang Zhao. Radiolabeled peptide probe for tumor imaging[J]. Chinese Chemical Letters, ;2022, 33(7): 3361-3370. doi: 10.1016/j.cclet.2022.02.016 shu

Radiolabeled peptide probe for tumor imaging

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190, China

wanghao@nanoctr.cn

zhaoyl@nanoctr.cn

Received Date: 17 November 2021
Revised Date: 9 February 2022
Accepted Date: 9 February 2022
Available Online: 14 February 2022

Figures(6)

Radionuclide imaging is now the premier imaging method in clinical practice for its high sensitivity and tomographic capability. Current clinically available radio imaging methods mostly use positron-emission tomography (PET) and single-photon emission computed tomography (SPECT) to detect anatomic abnormalities that conventional imaging techniques typically have challenges for visualizing. Contrast agents are indispensable for radionuclide imaging, and the radionuclide is always attached to a suitable vector that achieves targeted delivery. Nowadays, peptides have attracted increasing interest in targeting vectors of contrast agents, mainly due to their high specificity for target receptors at nanomolar concentrations and low toxicity. Radiolabeled peptide probes as kinds of PET/SPECT tracers had become essential tools for clinical radionuclide diagnosis. This review mainly summarizes radiolabeled peptide probes for bioimaging, including fundamental concepts of radiolabeled peptide probe design, some typical peptide analogs radiocontrast agents for PET, SPECT, and the combination imaging.
- Peptide,
- Positron-emission tomography (PET),
- Single-photon emission computed tomography (SPECT),
- Bioimaging
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沈阳化工大学材料科学与工程学院沈阳 110142