Citation: Ziyan Shen, Ning Ma, Feng Wang, Jiaming Ren, Chenxi Hou, Shuang Chao, Yuxin Pei, Zhichao Pei. pH- and H₂O₂-sensitive drug delivery system based on sodium xanthate: Dual-responsive supramolecular vesicles from one functional group[J]. Chinese Chemical Letters, ;2022, 33(10): 4563-4566. doi: 10.1016/j.cclet.2022.01.069 shu

pH- and H₂O₂-sensitive drug delivery system based on sodium xanthate: Dual-responsive supramolecular vesicles from one functional group

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A & F University, Yangling 712100, China

peizc@nwafu.edu.cn

Received Date: 28 November 2021
Revised Date: 24 January 2022
Accepted Date: 24 January 2022
Available Online: 1 February 2022

Figures(5)

Nano-drug delivery systems with multiple stimulus-responsive capabilities have superior response performance and efficient drug release. Nevertheless, it is sophisticated to construct multiple stimulus-responsive systems where the two or more functional groups need to be introduced simultaneously. Xanthate, one functional group with pH and H₂O₂ stimulus responsiveness, has significant potential applications for building dual-responsive drug delivery system. Herein, we present a novel dual stimuli-responsive supramolecular drug delivery system by using sodium xanthate derivative (SXD) as guest molecule and quaternary ammonium capped Pillar[5]arene (QAP5) as host molecule through host-guest interaction on the basis of electrostatic interaction. The amphiphile QAP5⊃SXD could self-assemble into vesicles to efficiently load the anti-cancer drug DOX. The experimental results showed that QAP5⊃SXD nanoparticles could achieve efficient drug delivery and controlled release in the tumor microenvironment. Cytotoxicity experiments proved that DOX@QAP5⊃SXD nanoparticles could significantly improve the anticancer efficiency of free DOX on cancer cells. The present study provides an efficient strategy to develop supramolecular nanocarriers with dual-responsiveness in one functional group for controlled drug release.
- Pillar[5]arene,
- Sodium xanthate,
- Host-guest interaction,
- pH- and H₂O₂-dual responsive,
- Controllable drug delivery
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

pH- and H2O2-sensitive drug delivery system based on sodium xanthate: Dual-responsive supramolecular vesicles from one functional group

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通讯作者: 陈斌, bchen63@163.com

pH- and H₂O₂-sensitive drug delivery system based on sodium xanthate: Dual-responsive supramolecular vesicles from one functional group