Citation: Manran Wu, Kexin Shi, Ruizhe Huang, Chunyi Liu, Lingling Yin, Weipeng Yong, Jing Sun, Guanglin Wang, Zhiyuan Zhong, Mingyuan Gao. Facile preparation of ¹⁷⁷Lu-microspheres for hepatocellular carcinoma radioisotope therapy[J]. Chinese Chemical Letters, ;2022, 33(7): 3492-3496. doi: 10.1016/j.cclet.2022.01.007 shu

Facile preparation of ¹⁷⁷Lu-microspheres for hepatocellular carcinoma radioisotope therapy

Manran Wu ^a ,
Kexin Shi ^a ,
Ruizhe Huang ^a ,
Chunyi Liu ^a ,
Lingling Yin ^a ,
Weipeng Yong ^a ,
Jing Sun ^a ,
Guanglin Wang ^{a, *,} ,
Zhiyuan Zhong ^b ,
Mingyuan Gao ^{a, *,}

a.
State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China
b.
Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China

glwang@suda.edu.cn

gaomy@iccas.ac.cn

Received Date: 3 November 2021
Revised Date: 29 December 2021
Accepted Date: 6 January 2022
Available Online: 13 January 2022

Figures(7)

As one of the most common cancers in the world, hepatocellular carcinoma (HCC) has become a major threat to human health. Radioembolization is a first-line option for the treatment of HCC, especially when other conventional treatments fail or there exist some relative contraindications. Herein, we developed a facile and efficient method for preparing ¹⁷⁷Lu-microspheres potentially useful for precise radioembolization therapy of HCC. The radiolabeling efficiency of ¹⁷⁷Lu-microspheres was as high as 96.8% ± 0.5%, and the radiolabeling process did not alter the morphology of the mother microspheres. The SPECT/CT studies enabled by the unique emissions of ¹⁷⁷Lu suggested that almost no ¹⁷⁷Lu ion loaded by the microspheres was released over more than 32 d in vivo, which led to remarkable inhibition effect on the growth of HepG2 tumors subcutaneously transplanted in mice. The current approach may thus offer promising ¹⁷⁷Lu-microspheres for clinical radioembolization of HCC.
- Radioisotope,
- Radioactive microspheres,
- Hepatocellular carcinoma,
- SPECT/CT,
- Radioembolization therapy
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Facile preparation of ¹⁷⁷Lu-microspheres for hepatocellular carcinoma radioisotope therapy