Citation: Xingyu Heng, Ruyan Feng, Lijuan Zhu, Liyin Yu, Gaojian Chen, Hong Chen. Dendritic cells maturation facilitated by group-adjustable lipopolysaccharide analogues synthesized via RAFT polymerization[J]. Chinese Chemical Letters, ;2022, 33(9): 4331-4334. doi: 10.1016/j.cclet.2021.12.032 shu

Dendritic cells maturation facilitated by group-adjustable lipopolysaccharide analogues synthesized via RAFT polymerization

Xingyu Heng ^{a, b} ,
Ruyan Feng ^a ,
Lijuan Zhu ^a ,
Liyin Yu ^a ,
Gaojian Chen ^{b, *,} ,
Hong Chen ^{a, *,}

a.
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
b.
Center for Soft Condensed Matter Physics and Interdisciplinary Research, Soochow University, Suzhou 215006, China

gchen@suda.edu.cn

chenh@suda.edu.cn

Received Date: 7 September 2021
Revised Date: 29 November 2021
Accepted Date: 13 December 2021
Available Online: 17 December 2021

Figures(5)

Transforming immature DCs into mature state to activate cellular immunity is a critical step in initiating immunoprophylaxis and immunotherapy. Lipopolysaccharides (LPS) can promote DCs maturation by binding receptor on DCs surface, but their clinical application is limited due to biological toxicity. Although many LPS analogues have been developed, complex synthesis and purification hinder their practical application. Here, we propose a novel and simple strategy to synthesize LPS analogues with adjustable structural units. Using monomer units similar to the key functional groups of LPS, we synthesize LPS analogues with different group ratios by RAFT polymerization. The obtained analogues have little negative effect on cell viability. Compared with LPS, the analogues show greater promoting effect on DCs maturation. And the analogues can be applied to different scenarios since the degrees of promoting DCs maturation by LPS analogues with different group ratios are different. This strategy provides a new direction for synthesizing LPS analogues, and it has the potential to produce LPS analogues on a large scale with tunable promoting DCs maturation effect.
- LPS analogues,
- Glycopolymer,
- RAFT polymerization,
- Dendritic cells (DCs),
- Immune enhancement
1. [1]
  M. Saxena, N. Bhardwaj, Trends Cancer 4 (2018) 119–137. doi: 10.1016/j.trecan.2017.12.007
2. [2]
  S. Zhang, G. Pang, C. Chen, et al., Carbohydr. Polym. 205 (2019) 192–202. doi: 10.1016/j.carbpol.2018.10.028
3. [3]
  S.K. Wculek, F.J. Cueto, A.M. Mujal, et al., Nat. Rev. Immunol. 20 (2020) 7–24. doi: 10.1038/s41577-019-0210-z
4. [4]
  H.J. Park, G.Y. Jang, Y.S. Kim, et al., J. Immunother. Cancer 7 (2019) 60. doi: 10.1186/s40425-019-0539-7
5. [5]
  Q. Zhang, W. Huang, M. Yuan, et al., ACS Appl. Mater. Interfaces 12 (2020) 54399–54414. doi: 10.1021/acsami.0c15522
6. [6]
  Y. Liu, L. Xiao, K.I. Joo, et al., Biomacromolecules 15 (2014) 3836–3845. doi: 10.1021/bm501166j
7. [7]
  X. Yang, T. Yu, Y. Zeng, et al., Biomacromolecules 21 (2020) 2818–2828. doi: 10.1021/acs.biomac.0c00518
8. [8]
  J. Banchereau, F. Briere, C. Caux, et al., Annu. Rev. Immunol. 18 (2000) 767–811. doi: 10.1146/annurev.immunol.18.1.767
9. [9]
  Y. Wang, C.G. Kelly, M. Singh, et al., J. Immunol. 169 (2002) 2422–2429. doi: 10.4049/jimmunol.169.5.2422
10. [10]
  J. Wang, L.B. Zhao, S. Chang, et al., J. Huazhong Univ. Sci. Technol. Med. 37 (2017) 191–196. doi: 10.1007/s11596-017-1714-z
11. [11]
  Y. Masuda, Y. Nakayama, T. Mukae, et al., Int. Immunopharmacol. 67 (2019) 408–416. doi: 10.1016/j.intimp.2018.12.039
12. [12]
  K. Damodar, J.K. Kim, J.G. Jun, Chin. Chem. Lett. 27 (2016) 698–702. doi: 10.1016/j.cclet.2016.01.043
13. [13]
  A. Basauri, C. González-Fernández, M. Fallanza, et al., Crit. Rev. Biotechnol. 40 (2020) 292–305. doi: 10.1080/07388551.2019.1709797
14. [14]
  Y. Wang, J.Y. Hwang, H.B. Park, et al., Carbohydr. Polym. 229 (2020) 115457. doi: 10.1016/j.carbpol.2019.115457
15. [15]
  M. Caroff, A. Novikov, LPS structure, function, and heterogeneity, in: K. Williams (eds), Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems, Springer: Cham, Switzerland, 2019, pp. 53–93.
16. [16]
  D. Rittirsch, M.A. Flierl, P.A. Ward, Nat. Rev. Immunol. 8 (2008) 776–787. doi: 10.1038/nri2402
17. [17]
  A. Hernandez, N.K. Patil, C.L. Stothers, et al., Pharmacol. Res. 150 (2019) 104502. doi: 10.1016/j.phrs.2019.104502
18. [18]
  A. Romerio, F. Peri, Front. Immunol. 11 (2020) 1210. doi: 10.3389/fimmu.2020.01210
19. [19]
  K.A. Gregg, E. Harberts, F.M. Gardner, et al., mBio 8 (2017) 00417.
20. [20]
  K.A. Gregg, E. Harberts, F.M. Gardner, et al., Vaccine 36 (2018) 4023–4031. doi: 10.1016/j.vaccine.2018.05.101
21. [21]
  J.T. Evans, C.W. Cluff, D.A. Johnson, et al., Expert Rev. Vaccines 2 (2003) 219–229. doi: 10.1586/14760584.2.2.219
22. [22]
  W.S. Bowen, L.A. Minns, D.A. Johnson, et al., Sci. Signal. 5 (2012) ra13.
23. [23]
  L. Gao, Q. Lian, L. Ma, et al., Chin. Chem. Lett. 32 (2021) 3011–3014. doi: 10.1016/j.cclet.2021.03.046
24. [24]
  G.C. Ireton, S.G. Reed, Expert Rev. Vaccines 12 (2013) 793–807. doi: 10.1586/14760584.2013.811204
25. [25]
  F. Adanitsch, S. Ittig, J. Stöckl, et al., J. Med. Chem. 57 (2014) 8056–8071. doi: 10.1021/jm500946r
26. [26]
  W. Song, J. Ji, K. Guo, et al., Chin. Chem. Lett. 33 (2022) 935–938. doi: 10.1016/j.cclet.2021.07.022
27. [27]
  M. Kohantorabi, S. Giannakis, G. Moussavi, et al., J. Hazard. Mater. 413 (2021) 125308. doi: 10.1016/j.jhazmat.2021.125308
28. [28]
  H. Jiang, Y. Du, L. Chen, et al., Int. J. Pharm. 586 (2020) 119606. doi: 10.1016/j.ijpharm.2020.119606
29. [29]
  P. Liu, W. Lin, R. Wieduwild, et al., Chem. Mater. 33 (2021) 2756–2768. doi: 10.1021/acs.chemmater.0c04105
30. [30]
  J. Chen, Y. Zhang, Y. Zhang, et al., Chin. Chem. Lett. 32 (2021) 3034–3038. doi: 10.1016/j.cclet.2021.03.079
31. [31]
  D.O. Carvalho, J. Freitas, P. Nogueira, et al., Food Chem. Toxicol. 121 (2018) 450–457. doi: 10.1016/j.fct.2018.09.021
32. [32]
  L. Zhang, D. Xie, X. Chen, et al., Antimicrob. Agents Chemother. 60 (2016) 5294–5301. doi: 10.1128/AAC.00641-16
33. [33]
  Y. Wang, Y. Xiang, V.W. Xin, et al., J. Hematol. Oncol. 13 (2020) 107. doi: 10.1186/s13045-020-00939-6
34. [34]
  E.J. Pearce, B. Everts, Nat. Rev. Immunol. 15 (2015) 18–29. doi: 10.1038/nri3771
35. [35]
  Q. Zhou, N. Gong, D. Zhang, et al., ACS Nano 15 (2021) 2920–2932. doi: 10.1021/acsnano.0c09120
36. [36]
  Y. Gu, B. Liu, Q. Liu, et al., ACS Appl. Mater. Interfaces 11 (2019) 47720–47729. doi: 10.1021/acsami.9b16882
1. [1]
  Bing Niu , Honggao Huang , Liwei Luo , Li Zhang , Jianbo Tan . Coating colloidal particles with a well-defined polymer layer by surface-initiated photoinduced polymerization-induced self-assembly and the subsequent seeded polymerization. Chinese Chemical Letters, 2025, 36(2): 110431-. doi: 10.1016/j.cclet.2024.110431
2. [2]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
3. [3]
  Hailong He , Wenbing Wang , Wenmin Pang , Chen Zou , Dan Peng . Double stimulus-responsive palladium catalysts for ethylene polymerization and copolymerization. Chinese Chemical Letters, 2024, 35(7): 109534-. doi: 10.1016/j.cclet.2024.109534
4. [4]
  Yuxin Tian , Mengjun Li , Yang Yang , Chunhui Li , Yun Peng , Haiyin Yang , Mengyuan Zhao , Pengfei Wu , Shaobo Ruan , Yuanyu Huang , Chenguang Shen , Minghui Yang . An MPXV mRNA-LNP vaccine candidate elicits protective immune responses against monkeypox virus. Chinese Chemical Letters, 2024, 35(8): 109270-. doi: 10.1016/j.cclet.2023.109270
5. [5]
  Wenbin Zhou , Yafei Gao , Xinyu Feng , Yanqing Zhang , Cong Yang , Lanxi He , Fenghe Zhang , Xiaoguang Li , Qing Li . Biomimetic nanoplatform integrates FRET-enhanced photodynamic therapy and chemotherapy for cascaded revitalization of the tumor immune microenvironment in OSCC. Chinese Chemical Letters, 2025, 36(1): 109763-. doi: 10.1016/j.cclet.2024.109763
6. [6]
  Xiangqian Cao , Chenkai Yang , Xiaodong Zhu , Mengxin Zhao , Yilin Yan , Zhengnan Huang , Jinming Cai , Jingming Zhuang , Shengzhou Li , Wei Li , Bing Shen . Synergistic enhancement of chemotherapy for bladder cancer by photothermal dual-sensitive nanosystem with gold nanoparticles and PNIPAM. Chinese Chemical Letters, 2024, 35(8): 109199-. doi: 10.1016/j.cclet.2023.109199
7. [7]
  Ziyi Liu , Xunying Liu , Lubing Qin , Haozheng Chen , Ruikai Li , Zhenghua Tang . Alkynyl ligand for preparing atomically precise metal nanoclusters: Structure enrichment, property regulation, and functionality enhancement. Chinese Journal of Structural Chemistry, 2024, 43(11): 100405-100405. doi: 10.1016/j.cjsc.2024.100405
8. [8]
  Guizhi Zhu , Junrui Tan , Longfei Tan , Qiong Wu , Xiangling Ren , Changhui Fu , Zhihui Chen , Xianwei Meng . Growth of CeCo-MOF in dendritic mesoporous organosilica as highly efficient antioxidant for enhanced thermal stability of silicone rubber. Chinese Chemical Letters, 2025, 36(1): 109669-. doi: 10.1016/j.cclet.2024.109669
9. [9]
  Xue Zhao , Mengshan Chen , Dan Wang , Haoran Zhang , Guangzhi Hu , Yingtang Zhou . Ultrafine nano-copper derived from dopamine polymerization & synchronous adsorption achieve electrochemical purification of nitrate to ammonia in complex water environments. Chinese Chemical Letters, 2024, 35(8): 109327-. doi: 10.1016/j.cclet.2023.109327
10. [10]
  Jian Song , Shenghui Wang , Qiuge Liu , Xiao Wang , Shuo Yuan , Hongmin Liu , Saiyang Zhang . N-Benzyl arylamide derivatives as novel and potent tubulin polymerization inhibitors against gastric cancers: Design, structure–activity relationships and biological evaluations. Chinese Chemical Letters, 2025, 36(2): 109678-. doi: 10.1016/j.cclet.2024.109678
11. [11]
  Fei Yin , Erli Yang , Xue Ge , Qian Sun , Fan Mo , Guoqiu Wu , Yanfei Shen . Coupling WO₃₋_x dots-encapsulated metal-organic frameworks and template-free branched polymerization for dual signal-amplified electrochemiluminescence biosensing. Chinese Chemical Letters, 2024, 35(4): 108753-. doi: 10.1016/j.cclet.2023.108753
12. [12]
  Chengcheng Xie , Chengyi Xiao , Hongshuo Niu , Guitao Feng , Weiwei Li . Mesoporous organic solar cells. Chinese Chemical Letters, 2024, 35(11): 109849-. doi: 10.1016/j.cclet.2024.109849
13. [13]
  Wenyi Mei , Lijuan Xie , Xiaodong Zhang , Cunjian Shi , Fengzhi Wang , Qiqi Fu , Zhenjiang Zhao , Honglin Li , Yufang Xu , Zhuo Chen . Design, synthesis and biological evaluation of fluorescent derivatives of ursolic acid in living cells. Chinese Chemical Letters, 2024, 35(5): 108825-. doi: 10.1016/j.cclet.2023.108825
14. [14]
  Chen Lu , Zefeng Yu , Jing Cao . Advancement in porphyrin/phthalocyanine compounds-based perovskite solar cells. Chinese Journal of Structural Chemistry, 2024, 43(3): 100240-100240. doi: 10.1016/j.cjsc.2024.100240
15. [15]
  Menglu Guo , Ying-Qi Song , Junfei Cheng , Guoqiang Dong , Xun Sun , Chunquan Sheng . Hydrophobic tagging-induced degradation of NAMPT in leukemia cells. Chinese Chemical Letters, 2024, 35(9): 109392-. doi: 10.1016/j.cclet.2023.109392
16. [16]
  Chi Li , Peng Gao . Is dipole the only thing that matters for inverted perovskite solar cells?. Chinese Journal of Structural Chemistry, 2024, 43(6): 100324-100324. doi: 10.1016/j.cjsc.2024.100324
17. [17]
  Chuan-Zhi Ni , Ruo-Ming Li , Fang-Qi Zhang , Qu-Ao-Wei Li , Yuan-Yuan Zhu , Jie Zeng , Shuang-Xi Gu . A chiral fluorescent probe for molecular recognition of basic amino acids in solutions and cells. Chinese Chemical Letters, 2024, 35(10): 109862-. doi: 10.1016/j.cclet.2024.109862
18. [18]
  Yinglan Yu , Sajid Hussain , Jianping Qi , Lei Luo , Xuemei Zhang . Mechanisms and applications: Cargos transport to basolateral membranes in polarized epithelial cells. Chinese Chemical Letters, 2024, 35(12): 109673-. doi: 10.1016/j.cclet.2024.109673
19. [19]
  Tianhao Li , Wenguang Tu , Zhigang Zou . In situ photocatalytically enhanced thermogalvanic cells for electricity and hydrogen production. Chinese Journal of Structural Chemistry, 2024, 43(1): 100195-100195. doi: 10.1016/j.cjsc.2024.100195
20. [20]
  Dai-Huo Liu , Ao Wang , Hong-Yan Lü , Xing-Long Wu , Dan Luo , Wen-Hao Li , Jin-Zhi Guo , Haozhen Dou , Qianyi Ma , Zhongwei Chen . In situ constructing (MnS/Mn₂SnS₄)@N,S-ACTs heterostructure with superior Na/Li-storage capabilities in half-cells and pouch full-cells. Chinese Chemical Letters, 2024, 35(11): 109285-. doi: 10.1016/j.cclet.2023.109285

Get Citation

PDF

XML

Metrics

PDF Downloads(5)
Abstract views(511)
HTML views(66)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142