Citation: Guangzhao Lu, Xiqing Gao, He Zhang, Yeye Zhang, Yuan Yu, Zhiguo Sun, Wei Li, Wei Wu, Ying Lu, Hao Zou. Near-infrared light (NIR)-responsive nanoliposomes combining photodynamic therapy and chemotherapy for breast tumor control[J]. Chinese Chemical Letters, ;2022, 33(4): 1923-1926. doi: 10.1016/j.cclet.2021.11.039 shu

Near-infrared light (NIR)-responsive nanoliposomes combining photodynamic therapy and chemotherapy for breast tumor control

Guangzhao Lu ^{a, 1} ,
Xiqing Gao ^{a, 1} ,
He Zhang ^{a, 1} ,
Yeye Zhang ^b ,
Yuan Yu ^a ,
Zhiguo Sun ^a ,
Wei Li ^c ,
Wei Wu ^{d, *,} ,
Ying Lu ^{a, *,} ,
Hao Zou ^{a, *,}

a.
Department of Pharmaceutical Sciences, School of Pharmacy, Naval Medical University, Shanghai 200433, China
b.
Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200032, China
c.
Laboratory of Nano Biomedicine & International Joint Cancer Institute, Naval Medical University, Shanghai 200433, China
d.
Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 200032, China

wuwei@shmu.edu.cn

luying706@163.com

haozou@smmu.edu.cn

Received Date: 7 August 2021
Revised Date: 8 November 2021
Accepted Date: 12 November 2021
Available Online: 18 November 2021

Figures(4)

Light-responsive carriers have been used for the controlled release of antitumor drugs in recent years. However, most light-responsive vectors require high-energy ultraviolet or visible light to achieve local drug release, and ultraviolet light would cause cellular damage. Near-infrared light has a deeper tissue-penetration depths and minimal harm to tissues, but it is difficult to cleave the chemical bond directly. The aim of this study is to develop a novel near-infrared light-responsive carrier for local release of antitumor drugs. Unsaturated phospholipids can be oxidized by singlet oxygen to achieve liposomal drug release, and singlet oxygen can be produced by photosensitizer under light irradiation. A new near-infrared light-responsive nanoliposome was designed that imparts light-triggered local drug release. Nanoliposomes, which were composed of matrix phospholipids and unsaturated phospholipids, were prepared by ammonium sulfate gradient method, and loaded with antitumor drug doxorubicin (DOX) and photosensitizer 1, 4, 8, 11, 15, 18, 22, 25-octabutoxypalladium phthalocyanine. Under near-infrared light, photosensitizers could produce singlet oxygen and damage tumor cells by photodynamic therapy. Simultaneously, the unsaturated phospholipids were oxidized by singlet oxygen and result in DOX release, causing sustained cell damage by chemotherapy. Near-infrared light-responsive nanoliposomes exhibit enhanced anticancer activity owing to combined treatment of photodynamic therapy and chemotherapy. A new platform is thus offered for designing effective intracellular drug-release systems, holding great promise for future cancer therapy.
- Near-infrared light,
- Unsaturated phospholipids,
- Nanoliposomes,
- Photosensitizer,
- Singlet oxygen
1. [1]
  Z. Cheng, A. Al Zaki, J.Z. Hui, et al., Science 338 (2012) 903-910. doi: 10.1126/science.1226338
2. [2]
  C.D. Landon, D. Needham, J.Y. Park, M.W. Dewhirst, Open Nanomed. J. 3 (2011) 38-64.
3. [3]
  B.P. Timko, M. Arruebo, S.A. Shankarappa, et al., Proc. Natl. Acad. Sci. U. S. A. 111 (2014) 1349-1354. doi: 10.1073/pnas.1322651111
4. [4]
  H. Ren, Y. Wu, Y. Li, et al., Small 9 (2013) 3981-3986. doi: 10.1002/smll.201300628
5. [5]
  E.S. Lee, K. Na, H.B. You, J. Control. Release 103 (2005) 405-418. doi: 10.1016/j.jconrel.2004.12.018
6. [6]
  H. Epstein-Barash, G. Orbey, B.E. Polat, et al., Biomaterials 31 (2010) 5208-5217. doi: 10.1016/j.biomaterials.2010.03.008
7. [7]
  T. Hoare, B.P. T. imko, J. Santamaria, et al., Nano. Lett. 11 (2011) 1395-1400. doi: 10.1021/nl200494t
8. [8]
  J. Li, T. Yin, L. Wang, et al., Int. J. Pharm. 483 (2015) 38-48. doi: 10.1016/j.ijpharm.2015.02.002
9. [9]
  K.M. Poole, C.E. Nelson, R.V. Joshi, et al., Biomaterials 41 (2015) 166-175. doi: 10.1016/j.biomaterials.2014.11.016
10. [10]
  X. Hu, J. Tian, T. Liu, et al., Macromolecules 46 (2013) 6243-6256. doi: 10.1021/ma400691j
11. [11]
  A. Barhoumi, B. Salvador-Culla, D.S. K. ohane, Adv. Healthc. Mater. 4 (2015) 1159-1163. doi: 10.1002/adhm.201400768
12. [12]
  Y. Yang, B. Velmurugan, X. Liu, B. Xing, Small 9 (2013) 2937-2944. doi: 10.1002/smll.201201765
13. [13]
  X. Wang, G. Meng, S. Zhang, X. Liu, Sci. Rep. 6 (2016) 29911. doi: 10.1038/srep29911
14. [14]
  M.K. Gnanasammandhan, N.M. Idris, A. Bansal, et al., Nat. Protoc. 11 (2016) 688-713. doi: 10.1038/nprot.2016.035
15. [15]
  Z. Yang, D. Gao, X. Guo, et al., ACS Nano 14 (2020) 17442-17457. doi: 10.1021/acsnano.0c07721
16. [16]
  L. Tang, Z. Yang, Z. Zhou, et al., Theranostics 9 (2019) 1358-1368. doi: 10.7150/thno.32106
17. [17]
  G. Saravanakumar, H. Park, J. Kim, et al., J. Control. Release 327 (2020) 627-640. doi: 10.1016/j.jconrel.2020.09.010
18. [18]
  Y.Y. Zhang, G.Z. Lu, Y. Yu, et al., ACS Appl. Bio. Mater. 2 (2019) 495-503. doi: 10.1021/acsabm.8b00681
19. [19]
  D. Luo, N. Li, K.A. C. arter, et al., Small 12 (2016) 3039-3047. doi: 10.1002/smll.201503966
20. [20]
  A.Y. Rwei, J.J. Lee, C. Zhan, et al., Proc. Natl. Acad. Sci. U. S. A. 112 (2015) 15719-15724. doi: 10.1073/pnas.1518791112
21. [21]
  E.G. Randles, P.R. B. ergethon, Langmuir 29 (2013) 1490-1497. doi: 10.1021/la303526k
22. [22]
  G.Z. Lu, C. Hou, H. Zhang, et al., Acta Pharm. Sin. 52 (2017) 1942-1950.
1. [1]
  Yiling Li , Zekun Gao , Xiuxiu Yue , Minhuan Lan , Xiuli Zheng , Benhua Wang , Shuang Zhao , Xiangzhi Song . FRET-based two-photon benzo[a] phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109133-. doi: 10.1016/j.cclet.2023.109133
2. [2]
  Shenghui Tu , Anru Liu , Hongxiang Zhang , Lu Sun , Minghui Luo , Shan Huang , Ting Huang , Honggen Peng . Oxygen vacancy regulating transition mode of MIL-125 to facilitate singlet oxygen generation for photocatalytic degradation of antibiotics. Chinese Chemical Letters, 2024, 35(12): 109761-. doi: 10.1016/j.cclet.2024.109761
3. [3]
  Zhe Li , Ping-Zhao Liang , Li Xu , Fei-Yu Yang , Tian-Bing Ren , Lin Yuan , Xia Yin , Xiao-Bing Zhang . Three positive charge nonapoptotic-induced photosensitizer with excellent water solubility for tumor therapy. Chinese Chemical Letters, 2024, 35(8): 109190-. doi: 10.1016/j.cclet.2023.109190
4. [4]
  Du Liu , Yuyan Li , Hankun Zhang , Benhua Wang , Chaoyi Yao , Minhuan Lan , Zhanhong Yang , Xiangzhi Song . Three-in-one erlotinib-modified NIR photosensitizer for fluorescence imaging and synergistic chemo-photodynamic therapy. Chinese Chemical Letters, 2025, 36(2): 109910-. doi: 10.1016/j.cclet.2024.109910
5. [5]
  Yan Zhu , Jia Liu , Meiheng Lv , Tingting Wang , Dongxiang Zhang , Rong Shang , Xin-Dong Jiang , Jianjun Du , Guiling Wang . Heavy-atom-free orthogonal configurative dye 1,7-di-anthra-aza-BODIPY for singlet oxygen generation. Chinese Chemical Letters, 2024, 35(10): 109446-. doi: 10.1016/j.cclet.2023.109446
6. [6]
  Chi Zhang , Ning Ding , Yuwei Pan , Lichun Fu , Ying Zhang . The degradation pathways of contaminants by reactive oxygen species generated in the Fenton/Fenton-like systems. Chinese Chemical Letters, 2024, 35(10): 109579-. doi: 10.1016/j.cclet.2024.109579
7. [7]
  Qihang Wu , Hui Wen , Wenhai Lin , Tingting Sun , Zhigang Xie . Alkyl chain engineering of boron dipyrromethenes for efficient photodynamic antibacterial treatment. Chinese Chemical Letters, 2024, 35(12): 109692-. doi: 10.1016/j.cclet.2024.109692
8. [8]
  Xin Lv , Hongxing Zhang , Kaibo Duan , Wenhui Dai , Zhihui Wen , Wei Guo , Junsheng Hao . Lighting the Way Against Cancer: Photodynamic Therapy. University Chemistry, 2024, 39(5): 70-79. doi: 10.3866/PKU.DXHX202309090
9. [9]
  Rongxin Zhu , Shengsheng Yu , Xuanzong Yang , Ruyu Zhu , Hui Liu , Kaikai Niu , Lingbao Xing . Construction of pyrene-based hydrogen-bonded organic frameworks as photocatalysts for photooxidation of styrene in water. Chinese Chemical Letters, 2024, 35(10): 109539-. doi: 10.1016/j.cclet.2024.109539
10. [10]
  Hui Peng , Xiao Wang , Weiguo Huang , Shuiyue Yu , Linghang Kong , Qilin Wei , Jialong Zhao , Bingsuo Zou . Efficient tunable visible and near-infrared emission in Sb³⁺/Sm³⁺-codoped Cs₂NaLuCl₆ for near-infrared light-emitting diode, triple-mode fluorescence anti-counterfeiting and information encryption. Chinese Chemical Letters, 2024, 35(11): 109462-. doi: 10.1016/j.cclet.2023.109462
11. [11]
  Wenxiang Ma , Xinyu He , Tianyi Chen , De-Li Ma , Hongzheng Chen , Chang-Zhi Li . Near-infrared non-fused electron acceptors for efficient organic photovoltaics. Chinese Chemical Letters, 2024, 35(4): 109099-. doi: 10.1016/j.cclet.2023.109099
12. [12]
  Yang Liu , Leilei Zhang , Kaixuan Liu , Ling-Ling Wu , Hai-Yu Hu . Penicillin G acylase-responsive near-infrared fluorescent probe: Unravelling biofilm regulation and combating bacterial infections. Chinese Chemical Letters, 2024, 35(11): 109759-. doi: 10.1016/j.cclet.2024.109759
13. [13]
  Huamei Zhang , Jingjing Liu , Mingyue Li , Shida Ma , Xucong Zhou , Aixia Meng , Weina Han , Jin Zhou . Imaging polarity changes in pneumonia and lung cancer using a lipid droplet-targeted near-infrared fluorescent probe. Chinese Chemical Letters, 2024, 35(12): 110020-. doi: 10.1016/j.cclet.2024.110020
14. [14]
  Yudi Cheng , Xiao Wang , Jiao Chen , Zihan Zhang , Jiadong Ou , Mengyao She , Fulin Chen , Jianli Li . A near-infrared fluorescent probe for visualizing transformation pathway of Cys/Hcy and H₂S and its applications in living system. Chinese Chemical Letters, 2024, 35(5): 109156-. doi: 10.1016/j.cclet.2023.109156
15. [15]
  Lei Wang , Jun-Jie Wu , Chang-Cun Yan , Wan-Ying Yang , Zong-Lu Che , Xin-Yu Xia , Xue-Dong Wang , Liang-Sheng Liao . Near-infrared organic lasers with ultra-broad emission bands by simultaneously harnessing four-level and six-level systems. Chinese Chemical Letters, 2024, 35(8): 109365-. doi: 10.1016/j.cclet.2023.109365
16. [16]
  Ying Zhao , Yin-Hang Chai , Tian Chen , Jie Zheng , Ting-Ting Li , Francisco Aznarez , Li-Long Dang , Lu-Fang Ma . Size-controlled synthesis and near-infrared photothermal response of Cp* Rh-based metalla[2]catenanes and rectangular metallamacrocycles. Chinese Chemical Letters, 2024, 35(6): 109298-. doi: 10.1016/j.cclet.2023.109298
17. [17]
  Yikun Wang , Qiaomei Chen , Shijie Liang , Dongdong Xia , Chaowei Zhao , Christopher R. McNeill , Weiwei Li . Near-infrared double-cable conjugated polymers based on alkyl linkers with tunable length for single-component organic solar cells. Chinese Chemical Letters, 2024, 35(4): 109164-. doi: 10.1016/j.cclet.2023.109164
18. [18]
  Xuan Zhu , Lin Zhou , Xiao-Yun Huang , Yan-Ling Luo , Xin Deng , Xin Yan , Yan-Juan Wang , Yan Qin , Yuan-Yuan Tang . (Benzimidazolium)2GeI4: A layered two-dimensional perovskite with dielectric switching and broadband near-infrared photoluminescence. Chinese Journal of Structural Chemistry, 2024, 43(6): 100272-100272. doi: 10.1016/j.cjsc.2024.100272
19. [19]
  Fuzheng Zhang , Chao Shi , Jiale Li , Fulin Jia , Xinyu Liu , Feiyang Li , Xinyu Bai , Qiuxia Li , Aihua Yuan , Guohua Xie . B-embedded narrowband pure near-infrared (NIR) phosphorescent iridium(Ⅲ) complexes and solution-processed OLED application. Chinese Chemical Letters, 2025, 36(1): 109596-. doi: 10.1016/j.cclet.2024.109596
20. [20]
  Leichen Wang , Anqing Mei , Na Li , Xiaohong Ruan , Xu Sun , Yu Cai , Jinjun Shao , Xiaochen Dong . Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy. Chinese Chemical Letters, 2024, 35(6): 108974-. doi: 10.1016/j.cclet.2023.108974

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(552)
HTML views(64)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142