Citation: Yilin Song, Huaqing Jing, Long Binh Vong, Jinping Wang, Nan Li. Recent advances in targeted stimuli-responsive nano-based drug delivery systems combating atherosclerosis[J]. Chinese Chemical Letters, ;2022, 33(4): 1705-1717. doi: 10.1016/j.cclet.2021.10.055 shu

Recent advances in targeted stimuli-responsive nano-based drug delivery systems combating atherosclerosis

Yilin Song ^{a, 1} ,
Huaqing Jing ^{a, 1} ,
Long Binh Vong ^{c, d} ,
Jinping Wang ^{b, *,} ,
Nan Li ^{a, *,}

a.
Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
b.
Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin 300401, China
c.
School of Biomedical Engineering, International University, Ho Chi Minh 700000, Vietnam
d.
Vietnam National University Ho Chi Minh City (VNU-HCMC), Ho Chi Minh 700000, Vietnam

wangjp@hebut.edu.cn

linan19850115@163.com

Received Date: 31 August 2021
Revised Date: 16 October 2021
Accepted Date: 19 October 2021
Available Online: 26 October 2021

Figures(9)

Atherosclerosis (AS), mainly caused by the changed immune system functions and inflammation, is the central pathogenesis of cardiovascular disease, which is a leading cause of death in the world. In modern medicine, the development of carriers precisely delivering the therapeutic agents to the target sites is the primary goal, which could minimize the potential adverse effects and be more effective in treating lesions. Due to the precise location, real-time monitoring, AS microenvironment response, and low toxicity, stimuli-responsive nano-based drug delivery systems (NDDSs) have been a promising approach in AS treatments. Herein, we will systematically summarize the recent advances in stimuli-responsive NDDSs for AS treatment, including internal stimuli (reactive oxygen species, enzyme, shear stress, and pH) and external stimuli (light, ultrasound, and magnetism) responsive NDDSs. Besides, we will also summarize in detail the classification of stimuli-responsive NDDSs for AS, such as organic NDDSs (e.g., lipid-based and polymer-based nanomaterials), inorganic NDDSs (e.g., metal-based nanoparticles and nonmetallic nanomaterials), and composite multifunctional NDDSs. Finally, the critical challenges and prospects of this field will also be proposed and discussed.
- Atherosclerosis stimuli-responsive,
- Nano-based drug delivery systems,
- Theranostics,
- Target therapy
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沈阳化工大学材料科学与工程学院沈阳 110142