Citation: Jinbin Yang, Yan Xu. Nanofluidics for sub-single cellular studies: Nascent progress, critical technologies, and future perspectives[J]. Chinese Chemical Letters, ;2022, 33(6): 2799-2806. doi: 10.1016/j.cclet.2021.09.066 shu

Nanofluidics for sub-single cellular studies: Nascent progress, critical technologies, and future perspectives

Jinbin Yang ^a ,
Yan Xu ^{a, b, c, *,}

a.
Department of Chemical Engineering, Graduate School of Engineering, Osaka Prefecture University, Sakai, Osaka 599-8570, Japan
b.
Japan Science and Technology Agency (JST), PRESTO, Kawaguchi, Saitama, 332-0012, Japan
c.
NanoSquare Research Institute, Research Center for the 21st Century, Organization for Research Promotion, Osaka Prefecture University, Sakai, Osaka 599-8570, Japan

xu@chemeng.osakafu-u.ac.jp

Received Date: 27 May 2021
Revised Date: 12 September 2021
Accepted Date: 20 September 2021
Available Online: 24 September 2021

Figures(7)

In the field of cell studies, there is a burgeoning trend to further downscale the investigation from a single-cell level to a sub-single-cell level. Subcellular matter is the basic content in cells and correlates with cell heterogeneity. Sub-single cellular studies focus on the subcellular matter in single cells and aim to understand the details and heterogeneity of individual cells in terms of the subcellular matter or even at the single component/vesicle/molecule level. Hence, sub-single cellular studies can provide deeper insights into fundamental cell biology and the development of new diagnostic and therapeutic technologies and applications. Nonetheless, the contents of a single cell are not only ultra-small in volume but also extremely complex in composition, far exceeding the capabilities of most tools used in current cell studies. We believe that nanofluidics holds great potential in providing ideal tools for sub-single cellular studies, not only because of their capability to handle femtoliter/attoliter-scale samples, but also because of their possibility to manipulate and analyze subcellular matters at the single component/vesicle/molecule level in a high-throughput manner. In this review, we summarize the efforts in the field of nanofluidics for sub-single cellular studies, focusing on nascent progress and critical technologies that have the potential to overcome the technical bottlenecks. Some challenges and future opportunities to integrate with information sciences are also discussed.
- Sub-single cellular matter,
- Single cell,
- Single molecule,
- Extracellular vesicles,
- Nanochannel,
- Femtoliter,
- Attoliter,
- Digital,
- Information sciences
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沈阳化工大学材料科学与工程学院沈阳 110142