Citation: Xiaoliang Zhang, Le Wang, Xiaochun Li, Xiujun Li. AuNP aggregation-induced quantitative colorimetric aptasensing of sulfadimethoxine with a smartphone[J]. Chinese Chemical Letters, ;2022, 33(6): 3078-3082. doi: 10.1016/j.cclet.2021.09.061 shu

AuNP aggregation-induced quantitative colorimetric aptasensing of sulfadimethoxine with a smartphone

Xiaoliang Zhang ^a ,
Le Wang ^a ,
Xiaochun Li ^{a, *,} ,
Xiujun Li ^{b, *,}

a.
College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China
b.
Department of Chemistry and Biochemistry, University of Texas at El Paso, El Paso, Texas 79968, United States

lixiaochun@tyut.edu.cn

xli4@utep.edu

Received Date: 4 July 2021
Revised Date: 9 September 2021
Accepted Date: 17 September 2021
Available Online: 24 September 2021

Figures(4)

A gold nanoparticle (AuNP) aggregation-induced colorimetric aptasensing method for quantitative detection of sulfadimethoxine (SDM) with a smartphone was developed. AuNPs were complexed with aptamers which protected AuNPs from aggregating in high-concentration salt solutions. In the presence of SDM, SDM bound with the aptamer on the surface of AuNPs with higher affinity, which competitively desorbed the aptamer from the AuNP surface and resulted in AuNPs aggregation, accompanied with a color change from red to purple-blue. The R, G and B values of images taken by a smartphone camera were analyzed with an app on the smartphone, and were utilized for quantitative analysis of SDM. Under the optimized conditions, the colorimetric aptasensing method using a smartphone showed high sensitivity for SDM, with the limit of detection of 0.023 ppm, lower than the allowed maximum SDM residue limit. This study provides a simple, fast, and easy to read method for on-site quantitative biochemical and cellular analysis.
- Smartphone,
- AuNP aggregation,
- Quantitative colorimetric assay,
- Antibiotics,
- Aptamer biosensor,
- Sulfadimethoxine
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