Citation: Kefurong Deng, Yachao Li, Xiaoyu Liang, Cheng Shen, Zenan Zeng, Xianghui Xu. Virus-inspired nanoparticles as versatile antibacterial carriers for antibiotic delivery against Gram-negative and Gram-positive bacteria[J]. Chinese Chemical Letters, ;2022, 33(3): 1619-1622. doi: 10.1016/j.cclet.2021.09.045 shu

Virus-inspired nanoparticles as versatile antibacterial carriers for antibiotic delivery against Gram-negative and Gram-positive bacteria

Department of Pharmacy, College of Biology, Hunan University, Changsha 410082, China

yachao_li@hotmail.com

xianghui.xu@hnu.edu.cn

xianghui.xu@hotmail.com

Received Date: 15 June 2021
Revised Date: 10 September 2021
Accepted Date: 13 September 2021
Available Online: 20 September 2021

Figures(5)

Infectious diseases become one of the leading causes of human death. Traditional treatment based on classical antibiotics could not provide enough antibacterial activity to combat bacterial infections due to low bioavailability, even leading to antibiotic resistance. In recent years, biomimetic delivery systems have been developed to improve drug therapy for various diseases, such as malignant tumor and cardiovascular disease. In this work, we designed virus-inspired nanodrugs (VNDs) through co-assembly of amphiphilic lipopeptide dendrons and poly(lactic-co-glycolic acid) polymers for high-efficiency antibiotic delivery. These VNDs had well-defined and stable nanostructures for tetracycline encapsulation and delivery. The VNDs were capable of promoting antibiotic internalization and enhancing their antibacterial effects against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. Additionally, no obvious cytotoxicity of VNDs was observed to human cell lines. This work successfully demonstrated the virus-mimetic nanoparticles served as promising and applicable antibiotic delivery platform for antibacterial treatment.
- Virus-inspired nanoparticles,
- Bacterial intracellular drug delivery,
- Antibacterial treatment,
- Gram-positive bacteria,
- Gram-negative bacteria
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