Citation: Yuan Xue, Duo Liu, Xuebin Wang, Yanxin Xiang, Shengjie Du, Kai Ye, Chunyan Bao, Linyong Zhu. A photopatterned SERS substrate with a sandwich structure for multiplex detection[J]. Chinese Chemical Letters, ;2022, 33(3): 1595-1598. doi: 10.1016/j.cclet.2021.09.016 shu

A photopatterned SERS substrate with a sandwich structure for multiplex detection

Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science & Technology, Shanghai 200237, China

baochunyan@ecust.edu.cn

linyongzhu@ecust.edu.cn

Received Date: 20 May 2021
Revised Date: 1 September 2021
Accepted Date: 3 September 2021
Available Online: 10 September 2021

Figures(6)

Substrate photopatterning has provided versatile applications in biomedical fields. Herein, an universal and efficient photoligation reaction has been used to prepare a patterned capture substrate for a sandwich SERS immunoassay. Photoirradiation induces mild and efficient immobilization of antibodies at the desired region of a gold surface, and the antibody-antigen interaction helps the substrate to capture the antigens in solution specifically. After exposing to SERS probes, i.e., the gold nanoparticles labelled with both antibodies and intrinsically strong Raman reporters, multiple quantitative SERS determination of antigens can be achieved with high sensitivity and specificity. The limit of detection can be as low as 10⁻¹² mol/L for four kinds of cancer biomarkers, which provides a promising method for the construction of highly sensitive and high-throughput SERS detection chip and the application of in vitro diagnosis.
- SERs detection,
- Photopatterning,
- Sandwich structure,
- Multiplex detection,
- Quantitative detection
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