Citation: Kosheli Thapa Magar, George Frimpong Boafo, Xiaotong Li, Zhongjian Chen, Wei He. Liposome-based delivery of biological drugs[J]. Chinese Chemical Letters, ;2022, 33(2): 587-596. doi: 10.1016/j.cclet.2021.08.020 shu

Liposome-based delivery of biological drugs

a.
Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
b.
Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China

aajian818@163.com

weihe@cpu.edu.cn

Received Date: 8 May 2021
Revised Date: 30 July 2021
Accepted Date: 5 August 2021
Available Online: 11 August 2021

Figures(5)

Biological drugs are attracting tremendous attention in disease treatment. However, their application is significantly limited by their inherent properties, such as high hydrophilicity, poor membrane-permeability, low stability, and larger size. Liposome-based drug delivery systems are emerging as promising tools to improve their delivery, owing to their ability to reduce toxicity, improve bioavailability, and enhance the therapeutic efficacy of the drug by optimizing delivery to the specific target site. Here, we reviewed the types of liposomes and their applications as carriers for biological drugs to treat various diseases, emphasized the commercial products, and ultimately provided perspectives in this field.
- Liposomes,
- Drug delivery,
- Biological drugs,
- Endocytosis,
- Toxicity
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沈阳化工大学材料科学与工程学院沈阳 110142