Citation: De-Ao Xu, Qing-Yang Zhou, Xianyin Dai, Xin-Kun Ma, Ying-Ming Zhang, Xiufang Xu, Yu Liu. Cucurbit[8]uril-mediated phosphorescent supramolecular foldamer for antibiotics sensing in water and cells[J]. Chinese Chemical Letters, ;2022, 33(2): 851-854. doi: 10.1016/j.cclet.2021.08.001 shu

Cucurbit[8]uril-mediated phosphorescent supramolecular foldamer for antibiotics sensing in water and cells

College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

ymzhang@nankai.edu.cn

yuliu@nankai.edu.cn

Received Date: 20 June 2021
Revised Date: 18 July 2021
Accepted Date: 2 August 2021
Available Online: 8 August 2021

Figures(5)

A phosphorescent supramolecular foldamer is conveniently constructed by the 1:1 host–guest complexation with cucurbit[8]uril and 1, 2-diaminocyclohexane-bridged 4-(4-bromophenyl)-pyridinium salt. The tightly compact host–guest complexation in molecular foldamer can greatly suppress the fluorescence emissive channel and promote the intersystem crossing from singlet to triplet states, thus leading to the green phosphorescence at ambient temperature in aqueous solution. More intriguingly, the phosphorescence emission shows very rapid and sensitive responsiveness to different antibiotics in both inanimate milieu and living cells. Remarkably, the limit of detection of such binary inclusion complex toward sulfamethazine can reach as low as 1.86 × 10⁻⁷ mol/L. Thus, it is envisaged that this supramolecular nanoplatform featuring unique complexation-enhanced phosphorescence emission may hold great promise in sensing and detecting many other biological targets under physiological environment.
- Supramolecular assembly,
- Cucurbiturils,
- Supramolecular foldamer,
- Phosphorescence sensing,
- Antibiotics detection
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