Citation: Qiang Wang, Hongjian Song, Qingmin Wang. Fluorine-containing agrochemicals in the last decade and approaches for fluorine incorporation[J]. Chinese Chemical Letters, ;2022, 33(2): 626-642. doi: 10.1016/j.cclet.2021.07.064 shu

Fluorine-containing agrochemicals in the last decade and approaches for fluorine incorporation

Qiang Wang ^{a, b} ,
Hongjian Song ^{a, *,} ,
Qingmin Wang ^{a, *,}

a.
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, China
b.
Department of Organic Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden

songhongjian@nankai.edu.cn

wangqm@nankai.edu.cn

Received Date: 25 May 2021
Revised Date: 16 July 2021
Accepted Date: 29 July 2021
Available Online: 4 August 2021

Figures(55)

In this review, the methodologies for fluorine incorporation of 40 fluorine-containing agrochemicals that received an international standardization organization (ISO) name during the last decade are described. The predominant approach for fluorine introduction of these agrochemicals is to use a fluorine-containing building block. Here we present how the fluorine-containing building blocks are introduced into these agrochemicals. The synthetic methods of fluorine-containing building blocks that are not easily available are also specifically discussed. Fluoroarenes, difluomethylarenes and trifluomethylarenes are the main building blocks that have been used in this review. Fluorine-containing small molecules, such as alcohol, amine, ketoester, olefin are also widely used. The only example of late-stage fluorination is the synthesis of fungicide quinofumelin. We believe the fluorine introduction methods described here can provide ideas for the development of new and economical pesticide synthetic routes, and stimulate researchers to develop new fluorine incorporation methods and create new pesticides.
- Fluorine-containing agrochemicals,
- Fluorine-containing building blocks,
- Fluorine introduction,
- Fungicides,
- Insecticides,
- Herbicides
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