Citation: Ning Jiang, Zaigang Zhou, Wei Xiong, Jiashe Chen, Jianliang Shen, Rongtao Li, Ruirong Ye. Tumor microenvironment triggered local oxygen generation and photosensitizer release from manganese dioxide mineralized albumin-ICG nanocomplex to amplify photodynamic immunotherapy efficacy[J]. Chinese Chemical Letters, ;2021, 32(12): 3948-3953. doi: 10.1016/j.cclet.2021.06.053 shu

Tumor microenvironment triggered local oxygen generation and photosensitizer release from manganese dioxide mineralized albumin-ICG nanocomplex to amplify photodynamic immunotherapy efficacy

Ning Jiang ^{a, 1} ,
Zaigang Zhou ^{b, c, 1} ,
Wei Xiong ^d ,
Jiashe Chen ^{b, c} ,
Jianliang Shen ^{b, c, *,} ,
Rongtao Li ^{a, *,} ,
Ruirong Ye ^{a, *,}

a.
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China
b.
State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China
c.
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China
d.
Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, China

shenjl@wiucas.ac.cn

rongtaolikm@163.com

yerr@mail2.sysu.edu.cn

Received Date: 13 January 2021
Revised Date: 11 June 2021
Accepted Date: 21 June 2021
Available Online: 1 July 2021

Figures(5)

Photodynamic therapy (PDT) has emerged as a potential clinical strategy for tumor therapy. It can generate reactive oxygen species (ROS) to cause the chemical damage of tumor cells and promote the immune killing effects of T cells on tumor cells in the presence of enough oxygen and PDT drugs. However, most solid tumors are in a state of oxygen deficiency, which seriously limit the efficacy of PDT in generation enough ROS. Besides, few safe PDT drugs with ideal pharmacokinetic behavior are available in the clinic, which severely limits the clinical transformation and application of PDT. Herein, we utilized manganese chloride to mineralize the hydrophilic indocyanine green/albumin polyplexes (ICG@BSA@MnO₂) by using bio-mineralized method to solve these problems of PDT. These ICG@BSA@MnO₂ nanoparticles could circulate in the blood for a long period other than quickly removed from body after 30 min like free ICG. When accumulated at the tumor site, ICG was responsively released in the presence of hydrogen peroxide. Apart this, the tumor hypoxia microenvironment was also reversed owing to enhanced O₂ generation by the reaction of MnO₂ with hydrogen peroxide. Benefits from the rich accumulation of ICG and ameliorated tumor hypoxia in the tumor sites, the enhanced generation of ROS could successfully promote the distribution of CD3⁺ and CD8⁺ T cells inside the tumors, which then lead to the amplified efficacy of PDT in both CT26 and B16F10 tumor models without causing any side effects.
- Photodynamic therapy,
- Bio-mineralized method,
- Hypoxia,
- Indocyanine green,
- Manganese dioxide
1. [1]
  C. Liu, L. Zhou, F. Wei, et al., ACS Appl. Mater. Interfaces 11(2019) 8797-8806. doi: 10.1021/acsami.8b20224
2. [2]
  X. Li, S. Lee, J. Yoon, Chem. Soc. Rev. 47(2018) 1174-1188. doi: 10.1039/C7CS00594F
3. [3]
  J. Cheng, H. Zhao, L. Yao, et al., ACS Appl. Mater. Interfaces 11(2019) 29498-29511. doi: 10.1021/acsami.9b07404
4. [4]
  G. Yang, L. Xu, Y. Chao, et al., Nat. Commun. 8(2017) 902. doi: 10.1038/s41467-017-01050-0
5. [5]
  W. Fan, P. Huang, X. Chen, Chem. Soc. Rev. 45(2016) 6488-6519. doi: 10.1039/C6CS00616G
6. [6]
  U. Chilakamarthi, L. Giribabu, Chem. Rec. 17(2017) 775-802. doi: 10.1002/tcr.201600121
7. [7]
  B.M. Luby, C.D. Walsh, G. Zheng, Angew. Chem. Int. Ed. 58(2019) 2558-2569. doi: 10.1002/anie.201805246
8. [8]
  X. Li, J.F. Lovell, J. Yoon, Nat. Rev. Clin. Oncol. 17(2020) 657-674. doi: 10.1038/s41571-020-0410-2
9. [9]
  A. Oniszczuk, K.A. Wojtunik-Kulesza, T. Oniszczuk, K. Kasprzak, Biomed. Pharmacother. 83(2016) 912-929. doi: 10.1016/j.biopha.2016.07.058
10. [10]
  S.H. Ibbotson, Photodermatol. Photoimmunol. Photomed. 27(2011) 116-130. doi: 10.1111/j.1600-0781.2010.00560.x
11. [11]
  H. Wang, X. Li, B.W. Tse, et al., Theranostics 8(2018) 1227-1242. doi: 10.7150/thno.22872
12. [12]
  X. Jiang, B. Du, J. Zheng, Nat. Nanotechnol. 14(2019) 874-882. doi: 10.1038/s41565-019-0499-6
13. [13]
  H. Yu, M. Ji, Mol. Imaging Biol. 23(2021) 160-172. doi: 10.1007/s11307-020-01545-1
14. [14]
  H. Hu, J. Chen, H. Yang, et al., Nanoscale 11(2019) 6384-6393. doi: 10.1039/C9NR01306G
15. [15]
  H.J. Yoon, H.S. Lee, J.Y. Lim, J.H. Park, ACS Appl. Mater. Interfaces 9(2017) 5683-5691. doi: 10.1021/acsami.6b16801
16. [16]
  F. An, Z. Yang, M. Zheng, et al., J. Nanobiotechnol. 18(2020) 49. doi: 10.1186/s12951-020-00603-8
17. [17]
  A. Sahu, J.H. Lee, H.G. Lee, et al., J. Control. Release 236(2016) 90-99. doi: 10.1016/j.jconrel.2016.06.031
18. [18]
  D. Sun, Y. Huang, X. Zhang, et al., J. Mater. Chem. B 6(2018) 6969-6976. doi: 10.1039/C8TB01874J
19. [19]
  Y.Z. Wang, Y.J. Song, G.X. Zhu, et al., Chin. Chem. Lett. 29(2018) 1685-1688. doi: 10.1016/j.cclet.2017.12.004
20. [20]
  W.W. Zhu, Z.L. Dong, T.T. Fu, et al., Adv. Funct. Mater. 26(2016) 5490-5498. doi: 10.1002/adfm.201600676
21. [21]
  Q. Chen, L.Z. Feng, J.J. Liu, et al., Adv. Mater. 28(2016) 7129-7136. doi: 10.1002/adma.201601902
22. [22]
  L. Meng, Y. Cheng, S. Gan, et al., Mol. Pharm. 15(2018) 447-457. doi: 10.1021/acs.molpharmaceut.7b00808
23. [23]
  L. Meng, Y. Cheng, X. Tong, et al., ACS Nano 12(2018) 8308-8322. doi: 10.1021/acsnano.8b03590
24. [24]
  J. Wen, K. Yang, S. Sun, Chem. Commun. 56(2020) 7065-7079. doi: 10.1039/D0CC02782K
25. [25]
  X. Wang, K. Su, L. Tan, et al., ACS Appl. Mater. Interfaces 11(2019) 15014-15027. doi: 10.1021/acsami.8b22136
26. [26]
  J. Chen, Q. Chen, C. Liang, et al., Nanoscale 9(2017) 14826-14835. doi: 10.1039/C7NR05316A
27. [27]
  J. Ge, R. Cai, X. Chen, et al., Talanta 195(2019) 40-45. doi: 10.1016/j.talanta.2018.11.024
28. [28]
  X. Yi, L. Chen, X.Y. Zhong, et al., Nano Res. 9(2016) 3267-3278. doi: 10.1007/s12274-016-1205-8
29. [29]
  L. Zhou, Y. Wu, X. Meng, et al., Small 14(2018) e1801008. doi: 10.1002/smll.201801008
30. [30]
  Z. Chen, L. Liu, R. Liang, et al., ACS Nano 12(2018) 8633-8645. doi: 10.1021/acsnano.8b04371
31. [31]
  H. He, L. Liu, R. Liang, et al., Acta Biomater. 104(2020) 188-197. doi: 10.1016/j.actbio.2020.01.012
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2. [2]
  Yang Li , Xiaoxu Liu , Tianyi Ji , Man Zhang , Xueru Yan , Mengjie Yao , Dawei Sheng , Shaodong Li , Peipei Ren , Zexiang Shen . Potassium ion doped manganese oxide nanoscrolls enhanced the performance of aqueous zinc-ion batteries. Chinese Chemical Letters, 2025, 36(1): 109551-. doi: 10.1016/j.cclet.2024.109551
3. [3]
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4. [4]
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5. [5]
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6. [6]
  Yiling Li , Zekun Gao , Xiuxiu Yue , Minhuan Lan , Xiuli Zheng , Benhua Wang , Shuang Zhao , Xiangzhi Song . FRET-based two-photon benzo[a] phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109133-. doi: 10.1016/j.cclet.2023.109133
7. [7]
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8. [8]
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9. [9]
  Du Liu , Yuyan Li , Hankun Zhang , Benhua Wang , Chaoyi Yao , Minhuan Lan , Zhanhong Yang , Xiangzhi Song . Three-in-one erlotinib-modified NIR photosensitizer for fluorescence imaging and synergistic chemo-photodynamic therapy. Chinese Chemical Letters, 2025, 36(2): 109910-. doi: 10.1016/j.cclet.2024.109910
10. [10]
  Leichen Wang , Anqing Mei , Na Li , Xiaohong Ruan , Xu Sun , Yu Cai , Jinjun Shao , Xiaochen Dong . Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy. Chinese Chemical Letters, 2024, 35(6): 108974-. doi: 10.1016/j.cclet.2023.108974
11. [11]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
12. [12]
  Qihang Wu , Hui Wen , Wenhai Lin , Tingting Sun , Zhigang Xie . Alkyl chain engineering of boron dipyrromethenes for efficient photodynamic antibacterial treatment. Chinese Chemical Letters, 2024, 35(12): 109692-. doi: 10.1016/j.cclet.2024.109692
13. [13]
  Kun-Heng Li , Hong-Yang Zhao , Dan-Dan Wang , Ming-Hui Qi , Zi-Jian Xu , Jia-Mi Li , Zhi-Li Zhang , Shi-Wen Huang . Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death. Chinese Chemical Letters, 2024, 35(5): 108882-. doi: 10.1016/j.cclet.2023.108882
14. [14]
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15. [15]
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16. [16]
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17. [17]
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18. [18]
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19. [19]
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20. [20]
  Weidan Meng , Yanbo Zhou , Yi Zhou . Green innovation unleashed: Harnessing tungsten-based nanomaterials for catalyzing solar-driven carbon dioxide conversion. Chinese Chemical Letters, 2025, 36(2): 109961-. doi: 10.1016/j.cclet.2024.109961

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