Citation: Shuang Chen, Yongzhuo Liu, Ri Liang, Gaobo Hong, Jing An, Xiaojun Peng, Wen-Heng Zheng, Fengling Song. Self-assembly of amphiphilic peptides to construct activatable nanophotosensitizers for theranostic photodynamic therapy[J]. Chinese Chemical Letters, ;2021, 32(12): 3903-3906. doi: 10.1016/j.cclet.2021.06.041 shu

Self-assembly of amphiphilic peptides to construct activatable nanophotosensitizers for theranostic photodynamic therapy

Shuang Chen ^a ,
Yongzhuo Liu ^b ,
Ri Liang ^a ,
Gaobo Hong ^a ,
Jing An ^a ,
Xiaojun Peng ^a ,
Wen-Heng Zheng ^{c, *} ,
Fengling Song ^{a, d, *}

a.
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China
b.
Shandong Collaborative Innovation Center of Eco-Chemical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
c.
Department of Medical Imaging, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang 110042, China
d.
Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao 266237, China

Mir2yue2@163.com

songfl@dlut.edu.cn

songfl@sdu.edu.cn

Received Date: 5 May 2021
Revised Date: 11 June 2021
Accepted Date: 15 June 2021
Available Online: 21 June 2021

Figures(5)

A variety of nano-engineered photosensitizers have been developed for photodynamic therapy (PDT) of cancer diseases. However, traditional nano-engineering methods usually cannot avoid drug leakage and premature release, and have disadvantages such as low drug load and inaccurate release. The self-assembly strategy based on amphiphilic peptides has been considered to be more attractive nano-engineering method. Here we developed novel acid-activatable self-assembled nanophotosensitizers based on an amphiphilic peptide derivative. The peptide derivative was synthesized from a fluorescein molecule with thermally activated delayed fluorescence (TADF). The self-assembled nanophotosensitizers can specifically enter the tumor cells and disassemble inside lysosomes companied with "turn-on" fluorescence and photodynamic therapy effect. Such smart nanophotosensitizers will open new opportunities for cancer theranostics.
- Photodynamic therapy,
- Nanophotosensitizer,
- Peptides,
- Self-assembly,
- Acid-activatable
1. [1]
  C.A. Robertson, D.H. Evans, H. Abrahamse, J. Photochem. Photobiol. B 96(2009) 1-8. doi: 10.1016/j.jphotobiol.2009.04.001
2. [2]
  P. Agostinis, K. Berg, K.A. Cengel, et al., CA Cancer J. Clin. 61(2011) 250-281. doi: 10.3322/caac.20114
3. [3]
  A.P. Castano, T.N. Demidova, M.R. Hamblin, Photodiagnosis Photodyn. Ther. 2(2005) 1-23. doi: 10.1016/S1572-1000(05)00030-X
4. [4]
  J. Garcia-Zuazaga, K.D. Cooper, E.D. Baron, Expert Rev. Anticancer Ther. 5(2005) 791-800. doi: 10.1586/14737140.5.5.791
5. [5]
  S.B. Brown, E.A. Brown, I. Walker, Lancet Oncol. 5(2004) 497-508. doi: 10.1016/S1470-2045(04)01529-3
6. [6]
  M. Ethirajan, Y. Chen, P. Joshi, R.K. Pandey, Chem. Soc. Rev. 40(2011) 340-362. doi: 10.1039/B915149B
7. [7]
  D. Bechet, P. Couleaud, C. Frochot, et al., Trends Biotechnol. 26(2008) 612-621. doi: 10.1016/j.tibtech.2008.07.007
8. [8]
  T. Shigehiro, J. Masuda, S. Saito, et al., Nanomaterials 7(2017) 290. doi: 10.3390/nano7100290
9. [9]
  A.S. Derycke, P.A. de Witte, Adv. Drug Deliv. Rev. 56(2004) 17-30. doi: 10.1016/j.addr.2003.07.014
10. [10]
  L. Jiao, Y. Liu, X. Zhang, et al., ACS Cent. Sci. 6(2020) 747-759. doi: 10.1021/acscentsci.0c00071
11. [11]
  M. Gary-Bobo, Y. Mir, C. Rouxel, et al., Angew. Chem. Int. Ed. 50(2011) 11425-11429. doi: 10.1002/anie.201104765
12. [12]
  X. Chen, Z. Hu, L. Zhou, et al., Nanoscale Horiz. 6(2021) 33-42. doi: 10.1039/D0NH00469C
13. [13]
  C. Deng, Q. Zhang, J. Guo, X. Zhao, Z. Zhong, Adv. Drug Deliv. Rev. 160(2020) 199-211. doi: 10.1016/j.addr.2020.10.019
14. [14]
  B. Dong, S. Du, C. Wang, et al., ACS Nano 13(2019) 1421-1432.
15. [15]
  Y. Cong, L. Ji, Y.J. Gao, et al., Angew. Chem. Int. Ed. 58(2019) 4632-4637. doi: 10.1002/anie.201900135
16. [16]
  J. Gao, J. Zhan, Z. Yang, Adv. Mater. 32(2020) e1805798. doi: 10.1002/adma.201805798
17. [17]
  Y. Yuan, C.J. Zhang, M. Gao, et al., Angew. Chem. Int. Ed. 54(2015) 1780-1786. doi: 10.1002/anie.201408476
18. [18]
  B. Sun, R. Chang, S. Cao, et al., Angew. Chem. Int. Ed. 59(2020) 20582-20588. doi: 10.1002/anie.202008708
19. [19]
  A. Dehsorkhi, V. Castelletto, I.W. Hamley, J. Pept. Sci. 20(2014) 453-467. doi: 10.1002/psc.2633
20. [20]
  X. Li, C. Cao, P. Wei, et al., ACS Appl. Mater. Inter. 11(2019) 12327-12334. doi: 10.1021/acsami.9b01281
21. [21]
  F. Qiu, Y. Chen, C. Tang, X. Zhao, Int. J. Nanomedicine 13(2018) 5003-5022. doi: 10.2147/IJN.S166403
22. [22]
  M.J. Sis, M.J. Webber, Trends Pharmacol. Sci. 40(2019) 747-762. doi: 10.1016/j.tips.2019.08.003
23. [23]
  X. Xiong, F. Song, J. Wang, et al., J. Am. Chem. Soc. 136(2014) 9590-9597. doi: 10.1021/ja502292p
24. [24]
  X. Xiong, F. Song, S. Sun, J. Fan, X. Peng, Asian J. Org. Chem. 2(2013) 145-149. doi: 10.1002/ajoc.201200109
25. [25]
  W. Chen, F. Song, Chin. Chem. Lett. 30(2019) 1717-1730. doi: 10.1016/j.cclet.2019.08.032
26. [26]
  Z. Liu, W. Shi, G. Hong, et al., J. Control. Release 310(2019) 1-10. doi: 10.1016/j.jconrel.2019.08.001
27. [27]
  Z. Liu, F. Song, W. Shi, et al., ACS Appl. Mater. Inter. 11(2019) 15426-15435. doi: 10.1021/acsami.9b04488
28. [28]
  L. Oliveira-Ferrer, K. Legler, K. Milde-Langosch, Semin. Cancer Biol. 44(2017) 141-152. doi: 10.1016/j.semcancer.2017.03.002
29. [29]
  E. Buytaert, M. Dewaele, P. Agostinis, Biochim. Biophys. Acta 1776(2007) 86-107. doi: 10.1016/j.bbagen.2006.06.020
1. [1]
  Kun-Heng Li , Hong-Yang Zhao , Dan-Dan Wang , Ming-Hui Qi , Zi-Jian Xu , Jia-Mi Li , Zhi-Li Zhang , Shi-Wen Huang . Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death. Chinese Chemical Letters, 2024, 35(5): 108882-. doi: 10.1016/j.cclet.2023.108882
2. [2]
  Wei Su , Xiaoyan Luo , Peiyuan Li , Ying Zhang , Chenxiang Lin , Kang Wang , Jianzhuang Jiang . Phthalocyanine self-assembled nanoparticles for type Ⅰ photodynamic antibacterial therapy. Chinese Chemical Letters, 2024, 35(12): 109522-. doi: 10.1016/j.cclet.2024.109522
3. [3]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
4. [4]
  Yuanpeng Ye , Longfei Yao , Guofeng Liu . Engineering circularly polarized luminescence through symmetry manipulation in achiral tetraphenylpyrazine structures. Chinese Journal of Structural Chemistry, 2025, 44(2): 100460-100460. doi: 10.1016/j.cjsc.2024.100460
5. [5]
  Sifan Du , Yuan Wang , Fulin Wang , Tianyu Wang , Li Zhang , Minghua Liu . Evolution of hollow nanosphere to microtube in the self-assembly of chiral dansyl derivatives and inversed circularly polarized luminescence. Chinese Chemical Letters, 2024, 35(7): 109256-. doi: 10.1016/j.cclet.2023.109256
6. [6]
  Hao Zhang , Hao Liu , Ke Huang , Qingxiu Xia , Hongjie Xiong , Xiaohui Liu , Hui Jiang , Xuemei Wang . Ionic exchange based intracellular self-assembly of pitaya-structured nanoparticles for tumor imaging. Chinese Chemical Letters, 2025, 36(6): 110281-. doi: 10.1016/j.cclet.2024.110281
7. [7]
  Yuyao Guan , Baoting Yu , Jun Ding , Tingting Sun , Zhigang Xie . BODIPY photosensitizers for antibacterial photodynamic therapy. Chinese Chemical Letters, 2025, 36(8): 110645-. doi: 10.1016/j.cclet.2024.110645
8. [8]
  Yuwen Zhu , Xiang Deng , Yan Wu , Baode Shen , Lingyu Hang , Yuye Xue , Hailong Yuan . Formation mechanism of herpetrione self-assembled nanoparticles based on pH-driven method. Chinese Chemical Letters, 2025, 36(1): 109733-. doi: 10.1016/j.cclet.2024.109733
9. [9]
  Yu Qin , Mingyang Huang , Chenlu Huang , Hannah L. Perry , Linhua Zhang , Dunwan Zhu . O₂-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma. Chinese Chemical Letters, 2024, 35(7): 109171-. doi: 10.1016/j.cclet.2023.109171
10. [10]
  Yiling Li , Zekun Gao , Xiuxiu Yue , Minhuan Lan , Xiuli Zheng , Benhua Wang , Shuang Zhao , Xiangzhi Song . FRET-based two-photon benzo[a] phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109133-. doi: 10.1016/j.cclet.2023.109133
11. [11]
  Hao Cai , Xiaoyan Wu , Lei Jiang , Feng Yu , Yuxiang Yang , Yan Li , Xian Zhang , Jian Liu , Zijian Li , Hong Bi . Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(4): 108946-. doi: 10.1016/j.cclet.2023.108946
12. [12]
  Wenkai Liu , Yanxian Hou , Weijian Liu , Ran Wang , Shan He , Xiang Xia , Chengyuan Lv , Hua Gu , Qichao Yao , Qingze Pan , Zehou Su , Danhong Zhou , Wen Sun , Jiangli Fan , Xiaojun Peng . Se-substituted pentamethine cyanine for anticancer photodynamic therapy mediated using the hot band absorption process. Chinese Chemical Letters, 2024, 35(12): 109631-. doi: 10.1016/j.cclet.2024.109631
13. [13]
  Du Liu , Yuyan Li , Hankun Zhang , Benhua Wang , Chaoyi Yao , Minhuan Lan , Zhanhong Yang , Xiangzhi Song . Three-in-one erlotinib-modified NIR photosensitizer for fluorescence imaging and synergistic chemo-photodynamic therapy. Chinese Chemical Letters, 2025, 36(2): 109910-. doi: 10.1016/j.cclet.2024.109910
14. [14]
  Liangliang Jia , Ye Hong , Xinyu He , Ying Zhou , Liujiao Ren , Hongjun Du , Bin Zhao , Bin Qin , Zhe Yang , Di Gao . Fighting hypoxia to improve photodynamic therapy-driven immunotherapy: Alleviating, exploiting and disregarding. Chinese Chemical Letters, 2025, 36(2): 109957-. doi: 10.1016/j.cclet.2024.109957
15. [15]
  Baoli Yin , Xinlin Liu , Zhe Li , Zhifei Ye , Youjuan Wang , Xia Yin , Sulai Liu , Guosheng Song , Shuangyan Huan , Xiao-Bing Zhang . Ratiometric NIR-Ⅱ fluorescent organic nanoprobe for imaging and monitoring tumor-activated photodynamic therapy. Chinese Chemical Letters, 2025, 36(5): 110119-. doi: 10.1016/j.cclet.2024.110119
16. [16]
  Quanxin Ning , Yidan Zhang , Huayi Sun , Xin Zhao , Haodong Zhang , Feng Cui , Xiaochun Xie , Fangman Chen , Wen Sun , Hong Zhang . Light-harvesting pigment-binding protein-mimicking carbon dots for photodynamic therapy. Chinese Chemical Letters, 2025, 36(11): 111133-. doi: 10.1016/j.cclet.2025.111133
17. [17]
  Xiangrong Pan , Xixi Hou , Yuhang Du , Zhixin Pang , Shiyang He , Lan Wang , Jianxue Yang , Longfei Mao , Jianhua Qin , Haixia Wu , Baozhong Liu , Zhan Zhou , Lufang Ma , Chaoliang Tan . Solvent-mediated synthesis of 2D In-TCPP MOF nanosheets for enhanced photodynamic antibacterial therapy. Chinese Chemical Letters, 2025, 36(12): 110536-. doi: 10.1016/j.cclet.2024.110536
18. [18]
  Di Zhang , Xu He , Xiaoying Kang , Xue Meng , Ji Qi , Zhifang Wu , Ningbo Li . A photo-accelerated nanoplatform for image-guided synergistic chemo-photodynamic therapy. Chinese Chemical Letters, 2025, 36(12): 110942-. doi: 10.1016/j.cclet.2025.110942
19. [19]
  Hui Guo , Wen-Wen Li , Mei-Yin Wu , Jian-Bo Hu , Jun Wang , Yun Liu , Yang Zou , Chu-Luo Yang , Kai-Lu Zheng . Indolizine-benzophenone hybrid acceptors enable TADF materials for bioimaging and photodynamic therapy in living cells. Chinese Chemical Letters, 2026, 37(1): 111721-. doi: 10.1016/j.cclet.2025.111721
20. [20]
  Mengyao Gao , Shan Sun , Hengwei Lin , Cheng Yang . A multifunctional carbon dot-based nanoplatform for antibacterial therapy: Integrating photodynamic, photothermal, and gas treatments. Chinese Chemical Letters, 2026, 37(2): 111055-. doi: 10.1016/j.cclet.2025.111055

Get Citation

PDF

XML

Metrics

PDF Downloads(3)
Abstract views(1510)
HTML views(125)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142