Citation: Yue Wang, Xueer Zhou, Wenxuan Wang, Yongyao Wu, Zhiyong Qian, Qiang Peng. Sodium bicarbonate, an inorganic salt and a potential active agent for cancer therapy[J]. Chinese Chemical Letters, ;2021, 32(12): 3687-3695. doi: 10.1016/j.cclet.2021.06.032 shu

Sodium bicarbonate, an inorganic salt and a potential active agent for cancer therapy

Yue Wang ^{a, 1} ,
Xueer Zhou ^{a, 1} ,
Wenxuan Wang ^a ,
Yongyao Wu ^a ,
Zhiyong Qian ^b ,
Qiang Peng ^{a, *,}

a.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
b.
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China

qiangpengzz@scu.edu.cn

Received Date: 10 April 2021
Revised Date: 9 June 2021
Accepted Date: 14 June 2021
Available Online: 23 June 2021

Figures(4)

Cancer is a serious threat to humans due to its high mortality. The efforts to fully understand cancer and to fight against it have never been stopped. The traditional therapies, such as surgery, radiotherapy and chemotherapy, are useful but cannot meet the increasing demands of patients. As such, novel approaches against cancer are urgently required. It has been found that the acidic tumor microenvironment plays important roles in promoting the cancer progression. In recent years, sodium bicarbonate (NaHCO₃), a simple inorganic salt, has been found to be able to reverse the pH of tumor microenvironment and inhibit the invasion, metastasis, immune evasion, drug resistance and hypoxia of tumor cells. Thus, NaHCO₃-based therapy is a potential approach for the treatment of cancer, and the related studies have been increasingly reported. Herein, we aim to provide a comprehensive understanding of the acidic tumor microenvironment and summarize the applications and mechanisms of NaHCO₃ in cancer therapy. The combination of NaHCO₃ with chemotherapy, immunotherapy or nanoparticles systems is discussed. In addition, the concerns of NaHCO₃ in clinical use and the potential ways to use NaHCO₃ for cancer therapy are also discussed.
- Sodium bicarbonate,
- Cancer,
- Tumor microenvironment,
- Acidosis,
- Pharmacology
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沈阳化工大学材料科学与工程学院沈阳 110142