Citation: Pengchong Wang, Hongrui Ji, Shiyan Guo, Ying Zhang, Yan Yan, Ke Wang, Jianfeng Xing, Yalin Dong. One-pot synthesis of nuclear targeting carbon dots with high photoluminescence[J]. Chinese Chemical Letters, ;2021, 32(12): 3911-3915. doi: 10.1016/j.cclet.2021.05.005 shu

One-pot synthesis of nuclear targeting carbon dots with high photoluminescence

Pengchong Wang ^{a, b} ,
Hongrui Ji ^b ,
Shiyan Guo ^b ,
Ying Zhang ^b ,
Yan Yan ^{a, b} ,
Ke Wang ^{b, *,} ,
Jianfeng Xing ^{b, *,} ,
Yalin Dong ^{a, *,}

a.
Department of Pharmacy, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China
b.
School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China

perpetual1003@mail.xjtu.edu.cn

xajdxjf@mail.xjtu.edu.cn

dongyalin@mail.xjtu.edu.cn

Received Date: 2 March 2021
Revised Date: 23 April 2021
Accepted Date: 6 May 2021
Available Online: 16 May 2021

Figures(5)

Carbon dots (CDs) are novel fluorescent nanomaterials with good water solubility, high resistance to photobleaching and low toxicity. While, there are few studies elaborate on the relationship among reaction conditions, properties and applications of CDs. In this study, a series of CDs are synthesized through a one-pot hydrothermal method, and different reaction conditions are carried out to study the influencing factors of CDs properties. As a result, with the increase of temperature and reaction time, the particle size and zeta potential of CDs increased, the maximum emission wavelength red-shifted and the fluorescence quantum yield (QY) improved. Among them, CD₃₀₀₆ has good water solubility and highest QY of 81.4%, which is beneficial for its applications in bioimaging and ion detection. CD₃₀₀₆ is almost nontoxic in cells at a concentration of 500 μg/mL. In addition, the positive charged CD₃₀₀₆ shows nuclear targeting potential because of its combination with DNA through electrostatic interaction in nucleus. The properties of CDs can be greatly enhanced by controlling reaction conditions, and it provides great application prospects.
- Optimization of synthesis process,
- Fluorescence quantum yield improving,
- Nuclear targeting,
- Bioimaging,
- Ferric ion detection
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