Citation: Heng Wu, Rui Zhang, Bianxiang Hu, Yutong He, Yuehang Zhang, Liu Cai, Leyu Wang, Guobao Wang, Honghao Hou, Xiaozhong Qiu. A porous hydrogel scaffold mimicking the extracellular matrix with swim bladder derived collagen for renal tissue regeneration[J]. Chinese Chemical Letters, ;2021, 32(12): 3940-3947. doi: 10.1016/j.cclet.2021.04.043 shu

A porous hydrogel scaffold mimicking the extracellular matrix with swim bladder derived collagen for renal tissue regeneration

Heng Wu ^{a, b} ,
Rui Zhang ^{a, b} ,
Bianxiang Hu ^a ,
Yutong He ^b ,
Yuehang Zhang ^{a, b} ,
Liu Cai ^c ,
Leyu Wang ^c ,
Guobao Wang ^{a, *,} ,
Honghao Hou ^{b, *,} ,
Xiaozhong Qiu ^{b, *,}

a.
State Key Lab for Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
b.
Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
c.
Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China

nfyywanggb@163.com

ss.hhh89@hotmail.com

qqiuxzh@163.com

Received Date: 20 February 2021
Revised Date: 20 April 2021
Accepted Date: 22 April 2021
Available Online: 28 April 2021

Figures(6)

As a worldwide public health issue, chronic kidney disease still lacks of effective therapeutic approaches due to the challenges in conventional organ transplantation and dialysis. Renal tissue engineering offers an advantageous therapeutic or regenerative option over typical donor organ. However, despite the great progress of decellularized extracellular matrix based scaffold for the renal regeneration, several safety concerns and complex composition still remain to be addressed. Herein, the extracellular matrix-mimicking hydrogel scaffolds were developed through covalent and physical cross-linking between swim bladder-derived natural collagen (COL) and anti-fibrosis chondroitin sulfate (CS) derivatives. The biomimetic hydrogels showed proper mechanical property, excellent thermal stability and high biocompatibility both in vitro and in vivo, by altering the mass ratio of COL and CS. When implanted in partially nephrectomized rat model, the 1COL/2CS scaffold enable it recruit more native kidney cells, reduce the tubular damage, and even induce the regeneration of renal tubular-like tissue and restore renal metabolic function more effectively comparing with the pure 2COL and 2CS scaffold. These results suggest that the biomimetic scaffold is a promising functional platform for treating renal diseases.
- Swim bladder,
- Collagen I,
- Chondroitin sulfate,
- Extracellular matrix-mimicking hydrogel,
- Renal tissue regeneration
1. [1]
  A.C. Webster, E.V. Nagler, R.L. Morton, P. Masson, Lancet 389(2017) 1238-1252. doi: 10.1016/S0140-6736(16)32064-5
2. [2]
  V. Jha, G. Garcia-Garcia, K. Iseki, et al., Lancet 382(2013) 260-272. doi: 10.1016/S0140-6736(13)60687-X
3. [3]
  K.H. Moon, I.K. Ko, J.J. Yoo, A. Atala, Adv. Healthc. Mater. 99(2016) 112-119.
4. [4]
  P.Y. Dankers, J.M. Boomker, E.W. Meijer, E.R. Popa, M.J. van Luyn, J. Control. Release 152(2011) 177-185. doi: 10.1016/j.jconrel.2011.01.034
5. [5]
  Y.L. Yu, Y.K. Shao, Y.Q. Ding, et al., Biomaterials 35(2014) 6822-6828. doi: 10.1016/j.biomaterials.2014.04.074
6. [6]
  J.M. Aamodt, D.W. Grainger, Biomaterials 86(2016) 68-82. doi: 10.1016/j.biomaterials.2016.02.003
7. [7]
  Y. Zhu, Q. Zhang, X. Shi, D. Han, Adv. Mater. 31(2019) e1804950. doi: 10.1002/adma.201804950
8. [8]
  N. Annabi, A. Tamayol, J.A. Uquillas, et al., Adv. Mater. 26(2014) 85-123. doi: 10.1002/adma.201303233
9. [9]
  G. Liu, Z. Bao, J. Wu, Chin. Chem. Lett. 31(2020) 1817-1821. doi: 10.1016/j.cclet.2020.03.005
10. [10]
  K. Yue, G. Trujillo-de Santiago, M.M. Alvarez, et al., Biomaterials 73(2015) 254-271. doi: 10.1016/j.biomaterials.2015.08.045
11. [11]
  D. Joladarashi, P.V. Salimath, N.D. Chilkunda, Glycobiology 21(2011) 960-972. doi: 10.1093/glycob/cwr029
12. [12]
  L. Kjellén, U. Lindahl, Annu. Rev. Biochem. 60(1991) 443-475. doi: 10.1146/annurev.bi.60.070191.002303
13. [13]
  A. Sorushanova, L.M. Delgado, Z. Wu, et al., Adv. Mater. 31(2019) e1801651. doi: 10.1002/adma.201801651
14. [14]
  M.C. Lane, M. Solursh, Dev. Biol. 143(1991) 389-397. doi: 10.1016/0012-1606(91)90089-L
15. [15]
  C.D. Nandini, K. Sugahara, Adv. Pharmacol. 53(2006) 253-279. doi: 10.1016/S1054-3589(05)53012-6
16. [16]
  A.I. Van Den Bulcke, B. Bogdanov, N. De Rooze, et al., Biomacromolecules 1(2000) 31-38. doi: 10.1021/bm990017d
17. [17]
  A. Jongjareonrak, S. Benjakul, W. Visessanguan, T. Nagai, M. Tanaka, Food Chem. 93(2004) 475. doi: 10.1016/j.foodchem.2004.10.026
18. [18]
  X. Zhang, M. Ookawa, Y. Tan, et al., Food Chem. 160(2014) 305-312. doi: 10.1016/j.foodchem.2014.03.075
19. [19]
  C.J. Chang, R. Minei, T. Sato, A. Taniguchi, Int. J. Mol. Sci. 20(2019) 5349. doi: 10.3390/ijms20215349
20. [20]
  J. Yang, M. Shen, H. Wen, et al., Carbohydr. Polym. 230(2020) 115650. doi: 10.1016/j.carbpol.2019.115650
21. [21]
  F. Legendre, C. Baugé, R. Roche, A.S. Saurel, J.P. Pujol, Osteoarthr. Cartil. 16(2008) 105-114. doi: 10.1016/j.joca.2007.05.020
22. [22]
  N.M. Melo-Filho, C.L. Belmiro, R.G. Gonçalves, et al., Am. J. Physiol. Renal Physiol. 299(2010) F1299-F1307. doi: 10.1152/ajprenal.00217.2010
23. [23]
  B. Corradetti, F. Taraballi, S. Minardi, et al., Stem Cells Transl. Med. 5(2016) 670-682. doi: 10.5966/sctm.2015-0233
24. [24]
  E. Renard, C. Chadjichristos, M. Kypriotou, et al., J. Cell. Mol. Med. 12(2008) 2836-2847. doi: 10.1111/j.1582-4934.2008.00287.x
25. [25]
  N.E. Ustyuzhanina, M.I. Bilan, E.G. Panina, N.P. Sanamyan, A.S. Dmitrenok, Mar. Drugs 16(2018) 389. doi: 10.3390/md16100389
26. [26]
  R.O. Sousa, A.L. Alves, J. Biomater. Sci. Polym. Ed. 31(2020) 20-37. doi: 10.1080/09205063.2019.1669313
27. [27]
  L. Wang, J. Jiang, W. Hua, et al., Adv. Funct. Mater. 26(2016) 4293. doi: 10.1002/adfm.201505372
28. [28]
  N. Annabi, J.W. Nichol, X. Zhong, et al., Tissue Eng. B: Rev. 16(2010) 371-383. doi: 10.1089/ten.teb.2009.0639
29. [29]
  S.M. Lien, L.Y. Ko, T.J. Huang, Acta Biomater. 5(2009) 670-679. doi: 10.1016/j.actbio.2008.09.020
30. [30]
  S. McLaughlin, B. McNeill, J. Podrebarac, K. Hosoyama, V. Sedlakova, Nat. Commun. 10(2019) 4866. doi: 10.1038/s41467-019-12748-8
31. [31]
  E. Lih, K.W. Park, S.Y. Chun, et al., ACS Appl. Mater. Interfaces 8(2016) 21145-21154. doi: 10.1021/acsami.6b03771
32. [32]
  X. Yang, Z. Li, H. Liu, et al., Int. J. Boil. Macromol. 143(2020) 190-199. doi: 10.1016/j.ijbiomac.2019.12.019
33. [33]
  S. Mathews, R. Bhonde, P.K. Gupta, S. Totey, J. Biomed. Mater. Res. B: Appl. Biomater. 102(2014) 1825-1834. doi: 10.1002/jbm.b.33152
34. [34]
  J.W. Nichol, S.T. Koshy, H. Bae, et al., Biomaterials 31(2010) 5536-5544. doi: 10.1016/j.biomaterials.2010.03.064
35. [35]
  R.G. Wells, Hepatology 47(2008) 1394-1400. doi: 10.1002/hep.22193
36. [36]
  Y. Ni, Z. Tang, W. Cao, et al., Int. J. Boil. Macromol. 74(2015) 367-375. doi: 10.1016/j.ijbiomac.2014.10.058
37. [37]
  M. Hu, E.U. Azeloglu, A. Ron, et al., Sci. Rep. 7(2017) 43934. doi: 10.1038/srep43934
38. [38]
  A.J. Engler, S. Sen, H.L. Sweeney, D.E. Discher, Cell 126(2006) 677-689. doi: 10.1016/j.cell.2006.06.044
39. [39]
  M. Yamagata, S. Suzuki, S.K. Akiyama, K.M. Yamada, K. Kimata, J. Biol. Chem. 264(1989) 8012-8018. doi: 10.1016/S0021-9258(18)83143-X
40. [40]
  H.S. Tran, F.A. Chrzanowski, M.M. Puc, et al., J. Surg. Res. 88(2000) 78-87. doi: 10.1006/jsre.1999.5714
41. [41]
  Y.M. Scindia, U.S. Deshmukh, H. Bagavant, Adv. Drug Deliv. Rev. 62(2010) 1337-1343. doi: 10.1016/j.addr.2010.08.011
42. [42]
  R. Ortega-Velazquez, M. Gonzalez-Rubio, M.P. Ruiz-Torres, et al., Am. J. Physiol. Cell Physiol. 286(2004) C1335-C1343. doi: 10.1152/ajpcell.00279.2003
43. [43]
  S. Bang, U.W. Jung, I. Noh, Tissue Eng. Regen. Med. 15(2018) 25-35. doi: 10.1007/s13770-017-0089-3
44. [44]
  C. Knupp, J.M. Squire, Adv. Protein Chem. 70(2005) 375-403. doi: 10.1016/S0065-3233(05)70011-5
45. [45]
  R. Chiquet-Ehrismann, Curr. Opin. Cell Biol. 7(1995) 715-719. doi: 10.1016/0955-0674(95)80114-6
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