Citation: Yongqing Zhou, Zhenzhen Liu, Guangming Qiao, Bo Tang, Ping Li. Visualization of endoplasmic reticulum viscosity in the liver of mice with nonalcoholic fatty liver disease by a near-infrared fluorescence probe[J]. Chinese Chemical Letters, ;2021, 32(11): 3641-3645. doi: 10.1016/j.cclet.2021.04.035 shu

Visualization of endoplasmic reticulum viscosity in the liver of mice with nonalcoholic fatty liver disease by a near-infrared fluorescence probe

Yongqing Zhou ^a ,
Zhenzhen Liu ^a ,
Guangming Qiao ^b ,
Bo Tang ^a ,
Ping Li ^{a, *,}

a.
College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institutes of Biomedical Sciences, Shandong Normal University, Jinan 250014, China
b.
Environment Pollution Control Center, Zibo 255000, China

lip@sdnu.edu.cn

Received Date: 19 February 2021
Revised Date: 8 April 2021
Accepted Date: 18 April 2021
Available Online: 27 April 2021

Figures(6)

Nonalcoholic fatty liver disease (NAFLD) can cause serious liver damage. Early diagnosis and effective treatment of NAFLD can greatly improve treatment rates. The initiation and development of NAFLD has been closely linked to endoplasmic reticulum (ER) stress, which might cause ER viscosity variations. Therefore, if the internal relationship between ER viscosity and NAFLD is clarified, an effective approach for early diagnosis may result. Herein, we fabricated a novel near-infrared (NIR) fluorescence imaging probe, Er-V, for monitoring ER viscosity through a molecular rotor strategy. Er-V exhibited a strong NIR fluorescence signal (at 626 nm) when the environmental viscosity hindered the rotation of the malononitrile group. Using Er-V, we successfully observed a significant enhancement in viscosity in the liver of mice with NAFLD. Therefore, this imaging method based on Er-V is expected to provide a new approach for early detection and diagnosis of NAFLD.
- Nonalcoholic fatty liver disease,
- Endoplasmic reticulum stress,
- Viscosity,
- Fluorescence imaging probe
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