Citation: Qing-Qing Han, Yuan-Yuan Sun, Shao-Hui Yang, Jing-Cheng Song, Zu-Li Wang. Persulfate promoted tandem radical cyclization of ortho-cyanoarylacrylamides with oxamic acids for construction of carbamoyl quinoline-2, 4-diones under metal-free conditions[J]. Chinese Chemical Letters, ;2021, 32(11): 3632-3635. doi: 10.1016/j.cclet.2021.04.019 shu

Persulfate promoted tandem radical cyclization of ortho-cyanoarylacrylamides with oxamic acids for construction of carbamoyl quinoline-2, 4-diones under metal-free conditions

College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China

wangzuli09@tsinghua.org.cn

Received Date: 2 March 2021
Revised Date: 7 April 2021
Accepted Date: 12 April 2021
Available Online: 17 April 2021

Figures(4)

An efficient and practical methods for the synthesis of carbamoyl quinoline-2, 4-diones via the reaction of ortho-cyanoarylacrylamides with oxamic acids was described. This cyclic reaction could be performed efficiently under metal free conditions. Various products with functional groups could be obtained with moderate to high yields via radical mechanism.
- Ortho-cyanoarylacrylamides,
- Oxamic acids,
- Quinoline-2, 4-diones,
- Metal-free,
- Persulfates
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