Citation: Lin Huang, Jun Xu, Lei He, Chenfeng Liang, Yani Ouyang, Yongping Yu, Wanmei Li, Pengfei Zhang. Rapid alkenylation of quinoxalin-2(1H)-ones enabled by the sequential Mannich-type reaction and solar photocatalysis[J]. Chinese Chemical Letters, ;2021, 32(11): 3627-3631. doi: 10.1016/j.cclet.2021.04.016 shu

Rapid alkenylation of quinoxalin-2(1H)-ones enabled by the sequential Mannich-type reaction and solar photocatalysis

Lin Huang ^{a, 1} ,
Jun Xu ^{a, 1} ,
Lei He ^a ,
Chenfeng Liang ^a ,
Yani Ouyang ^a ,
Yongping Yu ^b ,
Wanmei Li ^{a, *,} ,
Pengfei Zhang ^{a, *,}

a.
College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China
b.
College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China

liwanmei@hznu.edu.cn

pfzhang@hznu.edu.cn

Received Date: 19 February 2021
Revised Date: 2 April 2021
Accepted Date: 8 April 2021
Available Online: 20 April 2021

Figures(7)

Herein, a rapid alkenylation of quinoxalin-2(1H)-ones enabled by a combination of Mannich-type reaction and solar photocatalysis is demonstrated. A wide range of functional groups are compatible, affording the corresponding products in moderate-to-good yields. Control experiments illustrate that the in situ generated ¹O₂ plays a central role in this reaction. This green and efficient strategy provides a practical solution for the synthesis of potentially bioactive compounds that containing a 3, 4-dihydroquinoxalin-2(1H)-one structure.
- Alkenylation,
- Quinoxalin-2(1H)-ones,
- Methyl ketones,
- Mannich-type reaction,
- Solar photocatalysis
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