Citation: Xiaoqian Jiang, Chenfang Sun, Congcong Zhang, Shanshan Cheng. Highly responsive biosensors based on organic field-effect transistors under light irradiation[J]. Chinese Chemical Letters, ;2021, 32(11): 3364-3367. doi: 10.1016/j.cclet.2021.04.005 shu

Highly responsive biosensors based on organic field-effect transistors under light irradiation

a.
Department of Chemistry, Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Science, Tianjin University, Tianjin 300072, China
b.
Institute for Advanced Interdisciplinary Research, University of Jinan, Jinan 250011, China

chengss@tju.edu.cn

Received Date: 1 February 2021
Revised Date: 28 February 2021
Accepted Date: 1 April 2021
Available Online: 3 April 2021

Figures(4)

High responsivity and sensitivity play essential roles in the development of organic field-effect transistors (OFETs)-based biosensors with regard to biological detections, particularly for disease diagnosis. Nonetheless, how to design a biosensor which improves these two outstanding properties while achieving low cost, easy processing, and time saving is a daunting challenge. Herein, a novel biosensor based on OFET with copolymer thin film, whose surface is illuminated with a suitable light beam is reported. This film can be used as both an organic semiconductor material and as a photoelectric active material. Due to amplification of signals as a result of the film's strong response to light, the biosensor possesses higher responsivity and sensitivity compared to dark condition and even realizes a maximum responsivity of up to 10³ for alpha-fetoprotein (AFP) detection. The simple combination of light and transistor builds a bridge between photoelectric effect and biological system. In addition, the emergence of more excellent photoelectric active materials is expected to pave a way for ultrasensitive bio-chemical diagnostic tools.
- Organic field-effect transistors,
- Photoelectric active materials,
- Photo response,
- Biosensors,
- Disease diagnosis
1. [1]
  S.S. Li, C.W. Lin, K.C. Wei, et al., Sci. Rep. 6 (2016) 25155 doi: 10.1038/srep25155
2. [2]
  A. Sankiewicz, L. Romanowicz, M. Pyc, A. Hermanowicz, E. Gorodkiewicz, J. Pharm. Biomed. Anal. 150 (2018) 1–8 doi: 10.1016/j.jpba.2017.11.070
3. [3]
  Y. Ye, H. Guo, X. Sun, Biosens. Bioelectron. 116 (2018) 389–404 doi: 10.3390/plants8100389
4. [4]
  S. Bidmanova, M. Kotlanova, T. Rataj, et al., Biosens. Bioelectron. 84 (2016) 97–105 doi: 10.1016/j.bios.2015.12.010
5. [5]
  Y. Zang, D. Huang, C. Di, D. Zhu, Adv. Mater. 28 (2016) 4549–4555 doi: 10.1002/adma.201505034
6. [6]
  C. Zhang, P. Chen, W. Hu, Small 12 (2016) 1252–1294 doi: 10.1002/smll.201502546
7. [7]
  X. Ren, F. Yang, X. Gao, et al., Adv. Energy Mater. 8 (2018) 1801003 doi: 10.1002/aenm.201801003
8. [8]
  H. Li, W. Shi, J. Song, et al., Chem. Rev. 119 (2018) 3–35 doi: 10.1021/acs.chemrev.8b00016
9. [9]
  K. Zhou, K. Dai, C. Liu, C. Shen, SmartMat 1 (2020) e1010
10. [10]
  X. Wu, S. Mao, J. Chen, J. Huang, Adv. Mater. 30 (2018) 1705642 doi: 10.1002/adma.201705642
11. [11]
  H. Chen, S. Dong, M. Bai, et al., Adv. Mater. 27 (2015) 2113–2120 doi: 10.1002/adma.201405378
12. [12]
  T. Minamiki, Y. Sasaki, S. Tokito, T. Minami, Chemistry Open 6 (2017) 472–475 doi: 10.1002/open.201700070
13. [13]
  M.L. Hammock, O. Knopfmacher, B.D. Naab, J.B.H. Tok, Z. Bao, ACS. Nano 7 (2013) 3970–3980 doi: 10.1021/nn305903q
14. [14]
  X. Huang, D. Ji, H. Fuchs, W. Hu, T. Li, ChemPhotoChem 3 (2019) 1–31 doi: 10.1155/2019/6248725
15. [15]
  X. Wang, F. Zhao, Z. Xue, et al., Adv. Electron. Mater. 5 (2019) 1900174 doi: 10.1002/aelm.201900174
16. [16]
  P. Gu, M. Hu, S. Ding, et al., Chin. Chem. Lett. 29 (2018) 1675–1680 doi: 10.1016/j.cclet.2018.03.034
17. [17]
  S.H. Peng, T.W. Huang, G. Gollavelli, C.S. Hsu, J. Mater. Chem. C 5 (2017) 5193–5198 doi: 10.1039/C7TC00966F
18. [18]
  L. Zhang, S. Wan, Y. Jiang, et al., J. Am. Chem. Soc. 139 (2017) 2532–2540 doi: 10.1021/jacs.6b10646
19. [19]
  A. Mohammadinejad, R.K. Oskuee, R. Eivazzadeh-Keihan, et al., TrAC Trends Anal. Chem. 130 (2020) 115961 doi: 10.1016/j.trac.2020.115961
20. [20]
  H. Shen, C. A. Di, D. Zhu, Sci. China. Chem. 60 (2017) 437–449 doi: 10.1007/s11426-016-9014-9
21. [21]
  S. H. Yu, H. G. Girma, K. M. Sim, et al., Nanoscale 11 (2019) 17709–17717 doi: 10.1039/c9nr06096k
22. [22]
  J. Lee, A. R. Han, J. Kim, et al., J. Am. Chem. Soc. 134 (2012) 20713–20721 doi: 10.1021/ja308927g
23. [23]
  Y. Li, S. P. Singh, P. Sonar, Adv. Mater. 22 (2010) 4862–4866 doi: 10.1002/adma.201002313
24. [24]
  J. Li, Y. Zhao, H. S. Tan, et al., Sci. Rep. 2 (2012) 754–763 doi: 10.1038/srep00754
25. [25]
  Y. Yao, Y. Chen, H. Wang, P. Samorì, SmartMat 1 (2020) e1009
26. [26]
  Y. Lei, N. Li, W.K. E. Chan, B. S. Ong, F. Zhu, Org. Electron. 48 (2017) 12–18 doi: 10.1016/j.orgel.2017.05.029
27. [27]
  W. Huang, B. Yang, J. Sun, et al., Org. Electron. 15 (2014) 1050–1055 doi: 10.1016/j.orgel.2014.02.020
28. [28]
  J. Song, P. Lin, Y. F. Ruan, et al., Adv. Healthcare Mater. 7 (2018) 1800536 doi: 10.1002/adhm.201800536
29. [29]
  C. Sun, Y. Wang, M. Sun, et al., Biosens. Bioelectron. 164 (2020) 112251 doi: 10.1016/j.bios.2020.112251
1. [1]
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2. [2]
  Chang Liu , Tao Wu , Lijiao Deng , Xuzi Li , Xin Fu , Shuzhen Liao , Wenjie Ma , Guoqiang Zou , Hai Yang . Programmed DNA walkers for biosensors. Chinese Chemical Letters, 2024, 35(9): 109307-. doi: 10.1016/j.cclet.2023.109307
3. [3]
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5. [5]
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7. [7]
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8. [8]
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9. [9]
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11. [11]
  Yu He , Hao Jiang , Shaoxuan Yuan , Jiayi Lu , Qiang Sun . On-surface photo-induced dechlorination. Chinese Chemical Letters, 2024, 35(9): 109807-. doi: 10.1016/j.cclet.2024.109807
12. [12]
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13. [13]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
14. [14]
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15. [15]
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16. [16]
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19. [19]
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20. [20]
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1.
沈阳化工大学材料科学与工程学院沈阳 110142