Citation: Xiao Dan, Zhao Xin, Lei Jiang, Zhu Mengqian, Xu Liang. Synthesis of [6-6-6] ABE tricyclic ring analogues of methyllycaconitine[J]. Chinese Chemical Letters, ;2021, 32(10): 3031-3033. doi: 10.1016/j.cclet.2021.03.068 shu

Synthesis of [6-6-6] ABE tricyclic ring analogues of methyllycaconitine

Xiao Dan ^a ,
Zhao Xin ^a ,
Lei Jiang ^a ,
Zhu Mengqian ^a ,
Xu Liang ^{a, b, *}

a.
Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
b.
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China

liangxu@scu.edu.cn

Received Date: 10 February 2021
Revised Date: 23 March 2021
Accepted Date: 25 March 2021
Available Online: 27 March 2021

Figures(3)

A new synthesis of the bridged [6-6-6] ABE tricyclic ring analogues of methyllycaconitine with the C-1 oxygenated substituents has been developed using an efficient aza-annulation of β-enamino ketone followed by a facile decarboxylation to form BE rings. Subsequent elaboration to form the A ring was achieved by a transannular acyl radical cyclization with concomitant equipment of the key C-1 oxygen functionality.
- C₁₉-Diterpenoid alkaloids,
- Methyllycaconitine,
- Aza-annulation,
- Decarboxylation,
- Acyl radical cyclization
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